Diffuse bilateral cerebral astrocytomas with atypical neuroimaging studies.

Abstract:

:The authors describe the clinical behavior of eight patients with cerebral astrocytomas, in whom computerized tomography (CT) or magnetic resonance (MR) imaging of the brain was characterized by diffuse bilateral cerebral hemisphere tissue density abnormalities and minimal focal mass effect. Five patients were newly diagnosed, and three others had been treated for focal low-grade astrocytoma. Histological diagnoses included anaplastic astrocytoma (three patients), low-grade astrocytoma (three patients), glioblastoma (one patient), and gliosis with later development of glioblastoma (one patient). In five patients, brain tumor was not suspected from the neuroimaging studies, the findings of which were mistaken for radiation leukoencephalopathy, vasogenic edema, or multiple sclerosis. Serial CT scans or MR images undertaken over intervals of 3 to 184 weeks showed progression of abnormal tissue densities in seven patients and multifocal contrast-enhancing masses developed on CT scan in two patients. An autopsy in each of four patients showed diffuse cerebral infiltration by astrocytoma. It is concluded that neuroimaging studies in some patients with diffusely infiltrating cerebral astrocytoma are atypical for neoplasm and can be mistaken for other diseases, especially those that predominantly affect cerebral hemisphere white matter.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Rogers LR,Weinstein MA,Estes ML,Cairncross JG,Strachan T

doi

10.3171/jns.1994.81.6.0817

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

817-21

issue

6

eissn

0022-3085

issn

1933-0693

journal_volume

81

pub_type

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