Bayesian modeling and prediction of accrual in multi-regional clinical trials.

abstract：:Semicompeting risks and interval censoring are frequent in medical studies, for instance when a disease may be diagnosed only at times of visit and disease onset is in competition with death. To evaluate the ability of markers to predict disease onset in this context, estimators of discrimination measures must account...

journal_title：Statistical methods in medical research

authors： Jacqmin-Gadda H,Blanche P,Chary E,Touraine C,Dartigues JF

更新日期：2016-12-01 00:00:00

abstract：:This paper is based on a conference presentation in which several authors presented results from analyses of the same dataset concerning the evaluation of progression-free survival (PFS) as a surrogate endpoint for overall survival in advanced colorectal cancer clinical trials. In evaluating a potential surrogate endp...

journal_title：Statistical methods in medical research

authors： Hughes MD

更新日期：2008-10-01 00:00:00

abstract：:In this paper we review methods of cluster analysis in the context of classifying patients on the basis of clinical and/or laboratory type observations. Both hierarchical and non-hierarchical methods of clustering are considered, although the emphasis is on the latter type, with particular attention devoted to the mix...

journal_title：Statistical methods in medical research

authors： McLachlan GJ

更新日期：1992-01-01 00:00:00

abstract：:To evaluate the antiretroviral activity of antiretroviral agents and to compare the effects of two different antiretroviral agents, we propose a non-parametric mixed-effects model to investigate change of CD4+ counts. The proposed model and methods are applied to analyse the data from PACTG345 study. Population and in...

journal_title：Statistical methods in medical research

authors： Liang H

更新日期：2008-04-01 00:00:00

abstract：:Previous work has shown that individual randomized "proof-of-concept" (PoC) studies may be designed to maximize cost-effectiveness, subject to an overall PoC budget constraint. Maximizing cost-effectiveness has also been considered for arrays of simultaneously executed PoC studies. Defining Type III error as the oppor...

journal_title：Statistical methods in medical research

authors： He L,Du L,Antonijevic Z,Posch M,Korostyshevskiy VR,Beckman RA

更新日期：2020-09-21 00:00:00

abstract：:Statistical methods for carrying out asymptotic inferences (tests or confidence intervals) relative to one or two independent binomial proportions are very frequent. However, inferences about a linear combination of K independent proportions L = Σβ(i)p(i) (in which the first two are special cases) have had very little...

journal_title：Statistical methods in medical research

authors： Martín Andrés A,Alvarez Hernández M,Herranz Tejedor I

更新日期：2011-08-01 00:00:00

abstract：:The three-class Youden index serves both as a measure of medical test accuracy and a criterion to choose the optimal pair of cutoff values for classifying subjects into three ordinal disease categories (e.g. no disease, mild disease, advanced disease). We present a Bayesian nonparametric approach for estimating the th...

journal_title：Statistical methods in medical research

authors： Carvalho VI,Branscum AJ

更新日期：2018-03-01 00:00:00

abstract：:We propose a flexible and computationally efficient penalized estimation method for a semi-parametric linear transformation model with current status data. To facilitate model fitting, the unknown monotone function is approximated by monotone B-splines, and a computationally efficient hybrid algorithm involving the Fi...

journal_title：Statistical methods in medical research

authors： Lu M,Liu Y,Li CS

更新日期：2020-01-01 00:00:00

abstract：:In this paper, we describe a Bayesian hierarchical Poisson model for the prospective analysis of data for infectious diseases. The proposed model consists of two components. The first component describes the behavior of disease during nonepidemic periods and the second component represents the increase in disease coun...

journal_title：Statistical methods in medical research

authors： Corberán-Vallet A,Lawson AB

更新日期：2014-12-01 00:00:00

abstract：:The semiparametric Cox regression model is often fitted in the modeling of survival data. One of its main advantages is the ease of interpretation, as long as the hazards rates for two individuals do not vary over time. In practice the proportionality assumption of the hazards may not be true in some situations. In ad...

journal_title：Statistical methods in medical research

authors： Calsavara VF,Milani EA,Bertolli E,Tomazella V

更新日期：2020-08-01 00:00:00

abstract：:Understanding the limitation of solely relying on statistical significance, researchers have proposed methods to draw biomedical conclusions based on clinical significance. The minimal clinically important significance is one of the most fundamental concepts to study clinical significance. Based on an anchor question ...

journal_title：Statistical methods in medical research

authors： Zhou Z,Zhao J,Bisson LJ

更新日期：2020-03-01 00:00:00

abstract：:Measurement error is a serious problem in the analysis of epidemiological data. In the past 20 years, a large number of methods for the correction of measurement error have been developed. While at the beginning mostly methods for cohort studies were considered, recently more attention has been paid to case-control st...

journal_title：Statistical methods in medical research

authors： Thürigen D,Spiegelman D,Blettner M,Heuer C,Brenner H

更新日期：2000-10-01 00:00:00

abstract：:This article is motivated by jointly modelling longitudinal and time-to-event clinical data of patients with diabetes and end-stage renal disease. All patients are on the waiting list for the pancreas transplant after kidney transplant, and some of them have a pancreas transplant before kidney transplant failure or de...

journal_title：Statistical methods in medical research

authors： Dong JJ,Wang S,Wang L,Gill J,Cao J

更新日期：2019-09-01 00:00:00

abstract：:Joint models for recurrent and terminal events have not been yet developed for clustered data. The goals of our study are to develop a statistical framework for modelling clustered recurrent and terminal events and to perform dynamic predictions of the terminal event in family studies. We propose a joint nested frailt...

journal_title：Statistical methods in medical research

authors： Choi YH,Jacqmin-Gadda H,Król A,Parfrey P,Briollais L,Rondeau V

更新日期：2020-05-01 00:00:00

abstract：:In the past two decades, it has become increasingly clear that genetic factors contribute to the aetiology of many common diseases including cancers, coronary disease, allergy and psychiatric disorders. While one goal of genetic epidemiological studies is to locate susceptibility genes for these complex diseases, it i...

journal_title：Statistical methods in medical research

authors： Liang KY,Beaty TH

更新日期：2000-12-01 00:00:00

abstract：:Rapid Early Action for Coronary Treatment (REACT) was a multisite trial testing a community intervention to reduce the delay between onset of symptoms of acute myocardial infarction (MI) and patients' arrival at a hospital emergency department. The study employed a group-randomized trial design, with ten communities r...

journal_title：Statistical methods in medical research

authors： Murray DM,Feldman HA,McGovern PG

更新日期：2000-04-01 00:00:00

abstract：:Nonlinear mixed-effects modeling is one of the most popular tools for analyzing repeated measurement data, particularly for applications in the biomedical fields. Multiple integration and nonlinear optimization are the two major challenges for likelihood-based methods in nonlinear mixed-effects modeling. To solve thes...

journal_title：Statistical methods in medical research

authors： Yuan M,Zhu Z,Yang Y,Zhao M,Sasser K,Hamadeh H,Pinheiro J,Xu XS

更新日期：2020-08-24 00:00:00

abstract：:This article outlines the statistical developments that have taken place in the use of the EM algorithm in emission and transmission tomography during the past decade or so. We discuss the statistical aspects of the modelling of the projection data for both the emission and transmission cases and define the relevant p...

journal_title：Statistical methods in medical research

authors： Kay J

更新日期：1997-03-01 00:00:00

abstract：:In the field of diagnostic studies for tree or umbrella ordering, under which the marker measurement for one class is lower or higher than those for the rest unordered classes, there exist a few diagnostic measures such as the naive AUC ( NAUC), the umbrella volume ( UV), and the recently proposed TAUC, i.e. area unde...

journal_title：Statistical methods in medical research

authors： Feng Y,Tian L

更新日期：2019-05-01 00:00:00

abstract：:Conditional two-part random-effects models have been proposed for the analysis of healthcare cost panel data that contain both zero costs from the non-users of healthcare facilities and positive costs from the users. These models have been extended to accommodate more flexible data structures when using the generalize...

journal_title：Statistical methods in medical research

authors： Zhang B,Liu W,Hu Y

更新日期：2018-10-01 00:00:00

abstract：:With the emergence of rich information on biomarkers after treatments, new types of prognostic tools are being developed: dynamic prognostic tools that can be updated at each new biomarker measurement. Such predictions are of interest in oncology where after an initial treatment, patients are monitored with repeated b...

journal_title：Statistical methods in medical research

authors： Sène M,Taylor JM,Dignam JJ,Jacqmin-Gadda H,Proust-Lima C

更新日期：2016-12-01 00:00:00

abstract：:Cohen's kappa coefficient, κ, is a statistical measure of inter-rater agreement or inter-annotator agreement for qualitative items. In this paper, we focus on interval estimation of κ in the case of two raters and binary items. So far, only asymptotic and bootstrap intervals are available for κ due to its complexity. ...

journal_title：Statistical methods in medical research

authors： Shan G,Wang W

更新日期：2017-04-01 00:00:00

abstract：:In cluster randomized trials, clusters of subjects are randomized rather than subjects themselves, and missing outcomes are a concern as in individual randomized trials. We assessed strategies for handling missing data when analysing cluster randomized trials with a binary outcome; strategies included complete case, a...

journal_title：Statistical methods in medical research

authors： Caille A,Leyrat C,Giraudeau B

更新日期：2016-12-01 00:00:00

abstract：:A central assumption in the design and conduct of non-inferiority trials is that the active-control therapy will have the same degree of effectiveness in the planned non-inferiority trial as in the prior placebo-controlled trials used to define the non-inferiority margin. This is referred to as the 'constancy' assumpt...

journal_title：Statistical methods in medical research

authors： Hanscom B,Hughes JP,Williamson BD,Donnell D

更新日期：2019-10-01 00:00:00

abstract：:Cluster analysis via a finite mixture model approach is considered. With this approach to clustering, the data can be partitioned into a specified number of clusters g by first fitting a mixture model with g components. An outright clustering of the data is then obtained by assigning an observation to the component to...

journal_title：Statistical methods in medical research

authors： McLachlan GJ,Chang SU

更新日期：2004-10-01 00:00:00

abstract：:Sensitive questions are often involved in healthcare or medical survey research. Much empirical evidence has shown that the randomized response technique is useful for the collection of truthful responses. However, few studies have discussed methods to estimate the dependence of sensitive responses of multiple types. ...

journal_title：Statistical methods in medical research

authors： Chu AM,So MK,Chan TW,Tiwari A

更新日期：2020-03-01 00:00:00

abstract：:The ability to evaluate effects of factors on outcomes is increasingly important for studies that control some but not all of the factors. Although important advances have been made in methods of analysis for such partially controlled studies, work on designs has been limited. To help understand why, we review the mai...

journal_title：Statistical methods in medical research

authors： Li F,Frangakis CE

更新日期：2005-08-01 00:00:00

abstract：:Early phase trials of complex interventions currently focus on assessing the feasibility of a large randomised control trial and on conducting pilot work. Assessing the efficacy of the proposed intervention is generally discouraged, due to concerns of underpowered hypothesis testing. In contrast, early assessment of e...

journal_title：Statistical methods in medical research

authors： Wilson DT,Walwyn RE,Brown J,Farrin AJ,Brown SR

更新日期：2016-06-01 00:00:00

abstract：:Non-parametric linkage analysis examines similarities among affected relatives in alleles of one or more genetic markers (pieces of DNA at known locations on a chromosome). The objective is to evaluate departures from the null hypothesis that the markers are not near a disease gene. Under the null hypothesis, Mendel's...

journal_title：Statistical methods in medical research

authors： Shih MC,Whittemore AS

更新日期：2001-02-01 00:00:00

abstract：:Cancer mortality risk estimates are essential for planning resource allocation and designing and evaluating cancer prevention and management strategies. However, mortality figures generally become available after a few years, making necessary to develop reliable procedures to provide current and near future mortality ...

journal_title：Statistical methods in medical research

authors： Ugarte MD,Goicoa T,Etxeberria J,Militino AF

更新日期：2012-10-01 00:00:00