Abstract:
:In the past two decades, it has become increasingly clear that genetic factors contribute to the aetiology of many common diseases including cancers, coronary disease, allergy and psychiatric disorders. While one goal of genetic epidemiological studies is to locate susceptibility genes for these complex diseases, it is important that strong evidence of familial aggregation be established at an early stage of research. In this paper, we discuss several study designs useful to address some issues such as (1) detecting familial aggregation, (2) testing for gene-environment interaction, (3) identifying homogeneous subgroups and (4) measuring magnitude and patterns of familial correlations. These designs include the conventional case-control design and the family case-control design. For each of these two study designs, we discuss analytical strategies as well as their strengths and weaknesses. Throughout, several examples from real studies are used for illustrative purposes.
journal_name
Stat Methods Med Resjournal_title
Statistical methods in medical researchauthors
Liang KY,Beaty THdoi
10.1177/096228020000900603subject
Has Abstractpub_date
2000-12-01 00:00:00pages
543-62issue
6eissn
0962-2802issn
1477-0334journal_volume
9pub_type
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journal_title:Statistical methods in medical research
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journal_title:Statistical methods in medical research
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journal_title:Statistical methods in medical research
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doi:10.1177/0962280209347046
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doi:10.1177/0962280211426617
更新日期:2015-12-01 00:00:00
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pub_type: 传,历史文章,杂志文章,评审
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