Abstract:
:In this paper, a new allocation rule for treatment assignments in sequential clinical trials is proposed. The stratified and randomized play-the-winner rule (SRPWR) is an extension of the randomized play-the-winner rule to more than two treatments. It is applicable to cases where the probabilities of success of a treatment depend on both treatments and known confounders (e.g., patient's age, gender and disease status). On average, demonstrate that the SRPWR assigns more patients to the better treatment, while eliminating the selection bias and allowing delayed responses to treatments.
journal_name
Stat Methods Med Resjournal_title
Statistical methods in medical researchauthors
Liang Y,Carriere KCdoi
10.1177/0962280207081606subject
Has Abstractpub_date
2008-12-01 00:00:00pages
581-93issue
6eissn
0962-2802issn
1477-0334pii
0962280207081606journal_volume
17pub_type
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pub_type: 评论,信件
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