Abstract:
:Most statistical developments in the joint modelling area have focused on the shared random-effect models that include characteristics of the longitudinal marker as predictors in the model for the time-to-event. A less well-known approach is the joint latent class model which consists in assuming that a latent class structure entirely captures the correlation between the longitudinal marker trajectory and the risk of the event. Owing to its flexibility in modelling the dependency between the longitudinal marker and the event time, as well as its ability to include covariates, the joint latent class model may be particularly suited for prediction problems. This article aims at giving an overview of joint latent class modelling, especially in the prediction context. The authors introduce the model, discuss estimation and goodness-of-fit, and compare it with the shared random-effect model. Then, dynamic predictive tools derived from joint latent class models, as well as measures to evaluate their dynamic predictive accuracy, are presented. A detailed illustration of the methods is given in the context of the prediction of prostate cancer recurrence after radiation therapy based on repeated measures of Prostate Specific Antigen.
journal_name
Stat Methods Med Resjournal_title
Statistical methods in medical researchauthors
Proust-Lima C,Séne M,Taylor JM,Jacqmin-Gadda Hdoi
10.1177/0962280212445839subject
Has Abstractpub_date
2014-02-01 00:00:00pages
74-90issue
1eissn
0962-2802issn
1477-0334pii
0962280212445839journal_volume
23pub_type
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