Abstract:
:In this study, we discuss a decision theoretic or fully Bayesian approach to the sample size question in clinical trials with binary responses. Data are assumed to come from two binomial distributions. A Dirichlet distribution is assumed to describe prior knowledge of the two success probabilities p1 and p2. The parameter of interest is p = p1 - p2. The optimal size of the trial is obtained by maximising the expected net benefit function. The methodology presented in this article extends previous work by the assumption of dependent prior distributions for p1 and p2.
journal_name
Stat Methods Med Resjournal_title
Statistical methods in medical researchauthors
Pezeshk H,Nematollahi N,Maroufy V,Marriott P,Gittins Jdoi
10.1177/0962280211399562subject
Has Abstractpub_date
2013-12-01 00:00:00pages
598-611issue
6eissn
0962-2802issn
1477-0334pii
0962280211399562journal_volume
22pub_type
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