Estimating marginal and incremental effects in the analysis of medical expenditure panel data using marginalized two-part random-effects generalized Gamma models: Evidence from China healthcare cost data.

abstract：:Within paediatric populations, there may be distinct age groups characterised by different exposure-response relationships. Several regulatory guidance documents have suggested general age groupings. However, it is not clear whether these categorisations will be suitable for all new medicines and in all disease areas....

journal_title：Statistical methods in medical research

authors： Wadsworth I,Hampson LV,Bornkamp B,Jaki T

更新日期：2020-09-01 00:00:00

abstract：:Censored data make survival analysis more complicated because exact event times are not observed. Statistical methodology developed to account for censored observations assumes that patients' withdrawal from a study is independent of the event of interest. However, in practice, some covariates might be associated to b...

journal_title：Statistical methods in medical research

authors： Willems S,Schat A,van Noorden MS,Fiocco M

更新日期：2018-02-01 00:00:00

abstract：:The change-point model has drawn much attention over the past few decades. It can accommodate the jump process, which allows for changes of the effects before and after the change point. Intellectual disability is a long-term disability that impacts performance in cognitive aspects of life and usually has its onset pr...

journal_title：Statistical methods in medical research

authors： Cai B,Lawson AB,McDermott S,Aelion CM

更新日期：2016-04-01 00:00:00

abstract：:Increasing the clinical applicability of functional neuroimaging technology is an emerging objective, e.g. for diagnostic and treatment purposes. We propose a novel Bayesian spatial hierarchical framework for predicting follow-up neural activity based on an individual's baseline functional neuroimaging data. Our appro...

journal_title：Statistical methods in medical research

authors： Derado G,Bowman FD,Zhang L,Alzheimer's Disease Neuroimaging Initiative Investigators.

更新日期：2013-08-01 00:00:00

abstract：:Methods for the analysis of reliability of ordered categorical scales are discussed, focussing on the limitation of the single summary-weighted kappa coefficients. A symmetric matrix of kappa-type coefficients is suggested as an alternative. The method is proposed as being suitable for ordinal scale where there is no ...

journal_title：Statistical methods in medical research

authors： Roberts C,McNamee R

更新日期：2005-10-01 00:00:00

abstract：:Several epidemiological parameters have been introduced for quantifying the population impact of a certain exposure on morbidity on a population level, termed 'attributable risk' (AR). Of these definitions, the AR as suggested by Levin in 1953 or some algebraic transformations of it are most commonly used. A structure...

journal_title：Statistical methods in medical research

authors： Uter W,Pfahlberg A

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:When trials are subject to departures from randomised treatment, simple statistical methods that aim to estimate treatment efficacy, such as per protocol or as treated analyses, typically introduce selection bias. More appropriate methods to adjust for departure from randomised treatment are rarely employed,...

journal_title：Statistical methods in medical research

authors： Dodd S,Williamson P,White IR

更新日期：2019-03-01 00:00:00

abstract：:Count responses are becoming increasingly important in biostatistical analysis because of the development of new biomedical techniques such as next-generation sequencing and digital polymerase chain reaction; a commonly met problem in modeling them with the popular Poisson model is overdispersion. Although it has been...

journal_title：Statistical methods in medical research

authors： Zhang H,He H,Lu N,Zhu L,Zhang B,Zhang Z,Tang L

更新日期：2017-06-01 00:00:00

abstract：:This article is motivated by the need for discovering patterns of patients' health based on their daily settings of care to aid the health policy-makers to improve the effectiveness of distributing funding for health services. The hidden process of one's health status is assumed to be a continuous smooth function, cal...

journal_title：Statistical methods in medical research

authors： Wang S,Nie Y,Sutherland JM,Wang L

更新日期：2020-09-25 00:00:00

abstract：:Tracking a subject's risk factors or health status over time is an important objective in long-term epidemiological studies with repeated measurements. An important issue of time-trend tracking is to define appropriate statistical indices to quantitatively measure the tracking abilities of the targeted risk factors or...

journal_title：Statistical methods in medical research

authors： Wu CO,Tian X,Tian L,Reis JP,Zhao L,Allen NB,Bae S,Liu K

更新日期：2020-02-01 00:00:00

abstract：:This article is motivated by jointly modelling longitudinal and time-to-event clinical data of patients with diabetes and end-stage renal disease. All patients are on the waiting list for the pancreas transplant after kidney transplant, and some of them have a pancreas transplant before kidney transplant failure or de...

journal_title：Statistical methods in medical research

authors： Dong JJ,Wang S,Wang L,Gill J,Cao J

更新日期：2019-09-01 00:00:00

abstract：:Clinical trials are expensive and time-consuming and so should also be used to study how treatments work, allowing for the evaluation of theoretical treatment models and refinement and improvement of treatments. These treatment processes can be studied using mediation analysis. Randomised treatment makes some of the a...

journal_title：Statistical methods in medical research

authors： Goldsmith KA,Chalder T,White PD,Sharpe M,Pickles A

更新日期：2018-06-01 00:00:00

abstract：:Identification of cancer patient subgroups using high throughput genomic data is of critical importance to clinicians and scientists because it can offer opportunities for more personalized treatment and overlapping treatments of cancers. In spite of tremendous efforts, this problem still remains challenging because o...

journal_title：Statistical methods in medical research

authors： Wei W,Sun Z,da Silveira WA,Yu Z,Lawson A,Hardiman G,Kelemen LE,Chung D

更新日期：2019-07-01 00:00:00

abstract：:In the clinical development of some new infectious disease drugs, early clinical pharmacology trials may predict with high confidence that the efficacious doses are well below the range of the safety margin. In this case, a dose-ranging study may be unnecessary after a proof-of-concept (PoC) study testing the highest ...

journal_title：Statistical methods in medical research

authors： Fan XF,Gallo P,Su G,Menton R,Segal F

更新日期：2019-12-01 00:00:00

abstract：:This paper presents and compares several methods of measuring continuous baseline covariate imbalance in clinical trial data. Simulations illustrate that though the t-test is an inappropriate method of assessing continuous baseline covariate imbalance, the test statistic itself is a robust measure in capturing imbalan...

journal_title：Statistical methods in medical research

authors： Ciolino JD,Martin RH,Zhao W,Hill MD,Jauch EC,Palesch YY

更新日期：2015-04-01 00:00:00

abstract：:Multilevel models were originally developed to allow linear regression or ANOVA models to be applied to observations that are not mutually independent. This lack of independence commonly arises due to clustering of the units of observations into 'higher level units' such as patients in hospitals. In linear mixed model...

journal_title：Statistical methods in medical research

authors： Rabe-Hesketh S,Yang S,Pickles A

更新日期：2001-12-01 00:00:00

abstract：:Estimating the long-term health impact of air pollution using an ecological spatio-temporal study design is a challenging task, due to the presence of residual spatio-temporal autocorrelation in the health counts after adjusting for the covariate effects. This autocorrelation is commonly modelled by a set of random ef...

journal_title：Statistical methods in medical research

authors： Lee D,Mitchell R

更新日期：2014-12-01 00:00:00

abstract：:Cluster-level dynamic treatment regimens can be used to guide sequential treatment decision-making at the cluster level in order to improve outcomes at the individual or patient-level. In a cluster-level dynamic treatment regimen, the treatment is potentially adapted and re-adapted over time based on changes in the cl...

journal_title：Statistical methods in medical research

authors： NeCamp T,Kilbourne A,Almirall D

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Recent literature on the comparison of machine learning methods has raised questions about the neutrality, unbiasedness and utility of many comparative studies. Reporting of results on favourable datasets and sampling error in the estimated performance measures based on single samples are thought to be the m...

journal_title：Statistical methods in medical research

authors： Khondoker M,Dobson R,Skirrow C,Simmons A,Stahl D

更新日期：2016-10-01 00:00:00

abstract：:The random effects model in meta-analysis is a standard statistical tool often used to analyze the effect sizes of the quantity of interest if there is heterogeneity between studies. In the special case considered here, meta-analytic data contain only the sample means in two treatment arms and the sample sizes, but no...

journal_title：Statistical methods in medical research

authors： Sangnawakij P,Böhning D,Niwitpong SA,Adams S,Stanton M,Holling H

更新日期：2019-01-01 00:00:00

abstract：:Stochastic transmission dynamic models are needed to quantify the uncertainty in estimates and predictions during outbreaks of infectious diseases. We previously developed a calibration method for stochastic epidemic compartmental models, called Multiple Shooting for Stochastic Systems (MSS), and demonstrated its comp...

journal_title：Statistical methods in medical research

authors： Zimmer C,Leuba SI,Cohen T,Yaesoubi R

更新日期：2019-12-01 00:00:00

abstract：:Serial measurements of prostate-specific antigen (PSA) are used as a biomarker for men diagnosed with prostate cancer following an active monitoring programme. Distinguishing pathological changes from natural age-related changes is not straightforward. Here, we compare four approaches to modelling age-related change i...

journal_title：Statistical methods in medical research

authors： Simpkin AJ,Metcalfe C,Martin RM,Lane JA,Donovan JL,Hamdy FC,Neal DE,Tilling K

更新日期：2016-10-01 00:00:00

abstract：:One purpose of a longitudinal study is to gain a better understanding of how an outcome of interest changes among a given population over time. In what follows, a trajectory will be taken to mean the series of measurements of the outcome variable for an individual. Group-based trajectory modelling methods seek to iden...

journal_title：Statistical methods in medical research

authors： Davies CE,Glonek GF,Giles LC

更新日期：2017-08-01 00:00:00

abstract：:Couples with diseases associated with the sexual chromosomes, as well as families in countries where the desire for a male is extreme, are interested in influencing the sex of the baby. We propose an original composite likelihood approach to analyse the relation between sex of the newborn and timing of the intercourse...

journal_title：Statistical methods in medical research

authors： Tiberi S,Scarpa B,Sartori N

更新日期：2018-11-01 00:00:00

abstract：:Measurement error is a serious problem in the analysis of epidemiological data. In the past 20 years, a large number of methods for the correction of measurement error have been developed. While at the beginning mostly methods for cohort studies were considered, recently more attention has been paid to case-control st...

journal_title：Statistical methods in medical research

authors： Thürigen D,Spiegelman D,Blettner M,Heuer C,Brenner H

更新日期：2000-10-01 00:00:00

abstract：:This paper is based on a conference presentation in which several authors presented results from analyses of the same dataset concerning the evaluation of progression-free survival (PFS) as a surrogate endpoint for overall survival in advanced colorectal cancer clinical trials. In evaluating a potential surrogate endp...

journal_title：Statistical methods in medical research

authors： Hughes MD

更新日期：2008-10-01 00:00:00

abstract：:In this paper we review methods of cluster analysis in the context of classifying patients on the basis of clinical and/or laboratory type observations. Both hierarchical and non-hierarchical methods of clustering are considered, although the emphasis is on the latter type, with particular attention devoted to the mix...

journal_title：Statistical methods in medical research

authors： McLachlan GJ

更新日期：1992-01-01 00:00:00

abstract：:DNA methylation has been shown to play an important role in many complex diseases. The rapid development of high-throughput DNA methylation scan technologies provides great opportunities for genomewide DNA methylation-disease association studies. As methylation is a dynamic process involving time, it is quite plausibl...

journal_title：Statistical methods in medical research

authors： Wang C,Shen Q,Du L,Xu J,Zhang H

更新日期：2018-09-01 00:00:00

abstract：:Understanding the limitation of solely relying on statistical significance, researchers have proposed methods to draw biomedical conclusions based on clinical significance. The minimal clinically important significance is one of the most fundamental concepts to study clinical significance. Based on an anchor question ...

journal_title：Statistical methods in medical research

authors： Zhou Z,Zhao J,Bisson LJ

更新日期：2020-03-01 00:00:00

abstract：:This paper focuses on inferential tools in the logistic regression model fitted by the Firth penalized likelihood. In this context, the Likelihood Ratio statistic is often reported to be the preferred choice as compared to the 'traditional' Wald statistic. In this work, we consider and discuss a wider range of test st...

journal_title：Statistical methods in medical research

authors： Siino M,Fasola S,Muggeo VM

更新日期：2018-05-01 00:00:00