Abstract:
:Serial measurements of prostate-specific antigen (PSA) are used as a biomarker for men diagnosed with prostate cancer following an active monitoring programme. Distinguishing pathological changes from natural age-related changes is not straightforward. Here, we compare four approaches to modelling age-related change in PSA with the aim of developing reference ranges for repeated measures of PSA. A suitable model for PSA reference ranges must satisfy two criteria. First, it must offer an accurate description of the trend of PSA on average and in individuals. Second, it must be able to make accurate predictions about new PSA observations for an individual and about the entire PSA trajectory for a new individual.
journal_name
Stat Methods Med Resjournal_title
Statistical methods in medical researchauthors
Simpkin AJ,Metcalfe C,Martin RM,Lane JA,Donovan JL,Hamdy FC,Neal DE,Tilling Kdoi
10.1177/0962280213503928subject
Has Abstractpub_date
2016-10-01 00:00:00pages
1875-1891issue
5eissn
0962-2802issn
1477-0334pii
0962280213503928journal_volume
25pub_type
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