Abstract:
OBJECTIVE:To test the hypothesis that depressive symptoms correlate with Alzheimer's disease (AD) type changes in CSF and structural and functional imaging including hippocampus volume, cortical thickness, white matter lesions, Diffusion tensor imaging (DTI), and fluoro-deoxy-glucose positron emission tomography (FDG-PET) in patient with subjective (SCI) and mild (MCI) cognitive impairment. METHOD:In 60 patients, depressive symptoms were assessed using the Geriatric Depression Scale. The subjects underwent MRI, 18F-FDG PET imaging, and lumbar CSF extraction. RESULTS:Subjects with depressive symptoms (n=24) did not have more pathological AD biomarkers than non-depressed. Uncorrected there were trends towards larger hippocampal volumes (P=0.06), less orbital WM damage measured by DTI (P=0.10), and higher orbital glucose metabolism (P=0.02) in the depressed group. The findings were similar when SCI and MCI were analyzed separately. Similarly, in patients with pathological CSF biomarkers (i.e., predementia AD, n=24), we found that correlations between scores on GDS and CSF Aß42 and P-tau indicated less severe AD-specific CSF changes with increasing depression. CONCLUSION:Depressive symptoms are common in SCI/MCI, but are not associated with pathological imaging or CSF biomarkers of AD. Depression can explain cognitive impairment in SCI/MCI or add to cognitive impairment leading to an earlier clinical investigation in predementia AD.
journal_name
Acta Psychiatr Scandjournal_title
Acta psychiatrica Scandinavicaauthors
Auning E,Selnes P,Grambaite R,Šaltytė Benth J,Haram A,Løvli Stav A,Bjørnerud A,Hessen E,Hol PK,Muftuler løndalen A,Fladby T,Aarsland Ddoi
10.1111/acps.12352subject
Has Abstractpub_date
2015-02-01 00:00:00pages
139-47issue
2eissn
0001-690Xissn
1600-0447journal_volume
131pub_type
杂志文章abstract:OBJECTIVE:The aim of this study was to relate measures of psychoanalytically derived personality traits to descriptive diagnosis and psychopathology in severe mental disorders. METHOD:Sixty-one consecutive first-episode patients with schizophrenia, bipolar disorder and severe major depression were interviewed. Persona...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2003.00289.x
更新日期:2004-03-01 00:00:00
abstract::A Swedish version of the Camberwell Family Interview (CFI), a psychiatric, semistructured interview schedule for assessing a family's emotional atmosphere, is described. Thirty-two relatives of patients with schizophrenic disorders, according to DSM-III criteria, were interviewed. Eighteen relatives were interviewed t...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1991.tb03179.x
更新日期:1991-11-01 00:00:00
abstract::Emergency Psychiatric Service of the Department of Psychiatry at the University of Athens is the only referral service for the emergency psychiatric cases coming from the Athens greater area. During 1981 2,169 patients used the Service. The relations of socio-demographic and resource factors of the 26 districts of the...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1987.tb02758.x
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:Although previous studies have revealed an association between androgens and aggression, there is a lack of knowledge of this issue in different mental disorders. METHOD:The associations between serum testosterone levels and criminal behaviour in different mental disorders were examined using data collected ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1999.tb07240.x
更新日期:1999-05-01 00:00:00
abstract::Seventy Japanese DSM-III-R schizophrenic patients were assessed for 30 clinical symptoms using the Positive and Negative Syndrome Scale (PANSS) of Kay et al. Principal component analysis was applied to the full item set of this scale and disclosed 5 orthogonal independent symptom groups: negative, hostile/excited, tho...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1994.tb01536.x
更新日期:1994-06-01 00:00:00
abstract:OBJECTIVE:The study focuses on the controversial relationship between borderline personality disorder (BPD) and bipolar disorder (BD), defined according to different criteria set, in a world-wide sample of patients with a current major depressive episode (MDE). METHOD:A total of 5635 patients with an MDE were enrolled...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,多中心研究
doi:10.1111/acps.12083
更新日期:2013-11-01 00:00:00
abstract::Using a Lovibond flexible fibro-optic tintometer, no differences of skin pigmentation were found between chronic male schizophrenic patients untreated with phenothiazines, and non-schizophrenics. No differences were found between chronic male schizophrenics receiving phenothiazines and those not so treated. This latte...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1975.tb00010.x
更新日期:1975-06-01 00:00:00
abstract:OBJECTIVE:To assess the economic impact of the duration of antidepressant drug treatment in a real-life setting. METHOD:A historical fixed cohort study included 27 917 patients aged 18 and over with a new antidepressant treatment registered in the national insurance database. The economic impact concerned healthcare e...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.12035
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:To investigate the concept of 'Non-affective Acute Remitting Psychosis' (NARP) in a group of patients with first episode psychosis in Iran. METHOD:This is a 24-month follow-up study of 54 patients with first-episode psychosis admitted consecutively to a psychiatric hospital in Tehran, Iran. At the end of fol...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2005.00658.x
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:The study examined to what degree schizophrenia is characterized by a neuropsychological (NP) test profile specific in shape and level compared with depression and normal functioning. METHOD:Fifty-three patients with schizophrenia, 45 with non-psychotic depression, and 50 normals were assessed with a compreh...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2005.00626.x
更新日期:2006-04-01 00:00:00
abstract::The relationship between symptom disorder and personality disorder according to DSM-III was studied in 289 consecutive outpatients. It was observed that personality disorders occurred frequently among the chronic affective and anxiety disorders. The "dramatic" personality disorders were observed especially frequently ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1988.tb06371.x
更新日期:1988-10-01 00:00:00
abstract::A prospective study of 167 consecutive patients admitted to a general hospital following an episode of deliberate self-harm was carried out; 102 patients were interviewed by computer and then by a psychiatrist who was blind to the results of the computer interview. The computer interview consisted of a self-rating mod...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1989.tb01330.x
更新日期:1989-09-01 00:00:00
abstract:OBJECTIVE:To investigate the durability of positive effects of cognitive behaviour therapy (CBT) with coping training on psychotic symptoms and social functioning. METHOD:Forty patients with schizophrenia or related psychotic disorders and refractory auditory hallucinations were given CBT and coping training in an int...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0447.2001.00213.x
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVE:Chronically mentally ill patients in community mental health care report a better quality of life (QOL) than those in long-term hospital care, which suggests that the treatment setting per se influences their QOL. METHOD:In a region where both treatment settings are of a comparable high standard, we assessed...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1999.tb10835.x
更新日期:1999-08-01 00:00:00
abstract::Zuclopenthixol decanoate (ZPT-D) and haloperidol decanoate (HAL-D) were compared in the maintenance treatment of chronic schizophrenic patients. All patients were treated with either ZPT-D or HAL-D for at least 3 months and were then randomly allocated to treatment with either ZPT-D (100-600 mg every 4 weeks) or HAL-D...
journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1600-0447.1991.tb01414.x
更新日期:1991-07-01 00:00:00
abstract::Low levels of platelet monoamine oxidase have been found in schizophrenic and bipolar depressive patients. The enzyme activity seems to correlate negatively with certain personality traits (social activity, sensation seeking, hypomania, positive affect and monotony avoidance) which are correlated to some extent with t...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1981.tb00697.x
更新日期:1981-05-01 00:00:00
abstract:OBJECTIVE:Bipolar disorder in children and adolescents is less well studied than bipolar disorder in adults. This review addresses issues related to its underdiagnosis, precursors of bipolarity, comorbidity, natural course and treatment. METHOD:Literature from Medline and other searches, and earlier relevant articles ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,评审
doi:10.1034/j.1600-0447.2000.102003162.x
更新日期:2000-09-01 00:00:00
abstract::Pedigrees of manic-depressive patients in treatment at the Lithium Clinic of the Institute of Clinical Pharmacology, University of Cagliari, were evaluated for linkage between major affective illness and the protan-deutan-glucose-6-phosphate-dehydrogenase region of the X-chromosome. Two informative pedigrees were foun...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1984.tb01210.x
更新日期:1984-09-01 00:00:00
abstract:UNLABELLED:Lycanthropy is a rare psychiatric condition in which the patient believes in being transformed into an animal. Belief in the transformation of another person into an animal has not been reported, so far. Here, a patient with an impression of bipolar mood disorder (mixed type) and such delusion is reported. ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2006.00891.x
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:To examine whether variation at two common polymorphisms, T102C and -1438AG, of the serotonin 2A gene (5HT2A) are involved in the puerperal triggering mechanism of bipolar affective puerperal psychosis. METHOD:A total of 242 parous women diagnosed with bipolar disorder were genotyped for the two polymorphism...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0447.2003.00167.x
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:Cannabis is an acknowledged risk factor for some mental disorders, but for others the evidence is inconclusive. Prescribed medicinal drugs can be used as proxies for mental disorders. In this study, we investigate how use of cannabis is prospectively related to prescription of antipsychotics, mood stabilizers...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.13104
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:To test the association between recall for socially rewarding (positive) and/or socially critical (negative) information and depressive symptoms. METHOD:Cohort study of people who had visited UK primary care in the past year reporting depressive symptoms (N = 558, 69% female). Positive and negative recall wa...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.12729
更新日期:2017-05-01 00:00:00
abstract::The purpose of this study was to compare moclobemide and clomipramine in endogenous depression according to the Newcastle II classification. Sixty-two patients were allocated to either 300 mg moclobemide or 150 mg clomipramine, both given in 3 daily doses. Improvements occurred over time but differences between treatm...
journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1600-0447.1989.tb10298.x
更新日期:1989-06-01 00:00:00
abstract:OBJECTIVE:To review recent advances in the epidemiology, pathobiology, and management of weight gain and obesity in patients with schizophrenia and to evaluate the extent to which they should influence guidelines for clinical practice. METHOD:A Medline literature search was performed to identify clinical and experimen...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/acps.12445
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVE:To assess the methodological value of studies that signaled one or more selective serotonin reuptake inhibitors (SSRIs) as teratogenic agents. METHOD:Medical literature, published in English (1980-November 2010), was searched using MEDLINE/PubMed, TOXNET, EMBASE, and The Cochrane Library to identify all arti...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0447.2011.01673.x
更新日期:2011-04-01 00:00:00
abstract::A total of 1070 men and women aged 65 years and over living in the community in Liverpool were interviewed using the Geriatric Mental State. Diagnoses of depression at case and subcase level were made using the GMS-AGECAT package from an initial interview and at follow-up three years later. Data relating to blood pres...
journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1600-0447.1995.tb09752.x
更新日期:1995-02-01 00:00:00
abstract::A reliability study was carried out to compare the short Manchester Scale (MS) to the longer Brief Psychiatric Rating Scale (BPRS), to see if similar items scored the same aspect of pathology and to find the sources of error. The raters were a psychiatrist and a psychologist cum medical student; they had recently arri...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1986.tb06285.x
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND:A higher incidence of childhood trauma (CT) has been reported in first episode of psychosis (FEP). There is, however, a lack of knowledge about the synergetic effect between CT and recent stressful events (RSE). METHODS:Information on specific types of CT (under 17 years) and RSE (within the past 3 years) w...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.13114
更新日期:2020-01-01 00:00:00
abstract::Eight panic disorder patients participated in a double-blind placebo-controlled infusion study designed to induce panic-anxiety in the laboratory both before and after treatment with tricyclic antidepressants. Pre-infusion heart rates for the first infusion were significantly higher than baseline both before and after...
journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.1111/j.1600-0447.1987.tb02902.x
更新日期:1987-09-01 00:00:00
abstract::Efficacy and side effects of flurazepam 15 mg, fosazepam 60 mg, and nitrazepam 5 mg were studied in 17 psychogeriatric patients. The drugs were equipotent in maintaining sleep but nitrazepam had more side effects than the other hypnotics, and it induced a rebound insomnia after withdrawal. All hypnotics lost some of t...
journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.1111/j.1600-0447.1978.tb06871.x
更新日期:1978-01-01 00:00:00