Efficacy and side effects of flurazepam, fosazepam, and nitrazepam as sleeping aids in psychogeriatric patients.

Abstract:

:Efficacy and side effects of flurazepam 15 mg, fosazepam 60 mg, and nitrazepam 5 mg were studied in 17 psychogeriatric patients. The drugs were equipotent in maintaining sleep but nitrazepam had more side effects than the other hypnotics, and it induced a rebound insomnia after withdrawal. All hypnotics lost some of their efficacy towards the end of 7 days' administration. Patients with evident cerebrovascular disease were vulnerable to the side effects of the benzodiazepine hypnotics. The side effects did not correlate with the age of a patient. In addition, no correlations were found between the serum levels of fosazepam or its main metabolite and the side effects.

journal_name

Acta Psychiatr Scand

authors

Viukari M,Linnoila M,Aalto U

doi

10.1111/j.1600-0447.1978.tb06871.x

subject

Has Abstract

pub_date

1978-01-01 00:00:00

pages

27-35

issue

1

eissn

0001-690X

issn

1600-0447

journal_volume

57

pub_type

临床试验,杂志文章
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