Epigenetic modification in neuropathic pain.

abstract：:Although somewhat controversial, there is good evidence that long-distance travel in general is a risk factor for venous thromboembolism, even in the absence of other risk factors. This is probably due to effects consequent to prolonged sitting but air travel in particular may be associated with risk factors other tha...

journal_title：Current pharmaceutical design

authors： Bradford A

更新日期：2007-01-01 00:00:00

abstract：:Extracellular matrix (ECM) is composed of large collagen fibrils. Glycoproteins, such as fibronectin, can bind to collagen or form their own networks. Collagen fibrils are also decorated by proteoglycans, proteins that have large glycosaminoglycan sidechains. In addition, extracellular space often contains hyaluronan,...

journal_title：Current pharmaceutical design

authors： Heino J,Käpylä J

更新日期：2009-01-01 00:00:00

abstract：:The signal transducer and activator of transcription 3 (STAT3) transduces stress signals from the plasma membrane to the nucleus but has recently also been identified in mitochondria. Inhibition of cardiomyocyte mitochondrial STAT3 with the STAT3-specific inhibitor Stattic decreases ADP-stimulated respiration and enha...

journal_title：Current pharmaceutical design

authors： Boengler K,Ungefug E,Heusch G,Schulz R

更新日期：2013-01-01 00:00:00

abstract：:The majority of pharmaceutical formulations for the treatment of ocular pathologies are for topical administration. However, this kind of ophthalmic formulations has disadvantages such as low bioavailability and, consequently, a reduced therapeutic effect. This happens due to the anatomical and physiological specifici...

journal_title：Current pharmaceutical design

authors： Almeida H,Amaral MH,Lobao P,Frigerio C,Sousa Lobo JM

更新日期：2015-01-01 00:00:00

abstract：:Asthma is an allergy-mediated inflammatory disease characterised by infiltration of the airway with mast cells, lymphocytes, and eosinophils. The disease is induced by co-ordination of T-helper cell type 2 (Th2) cytokines and inflammatory signal molecules. Fruits and vegetables are a rich source of polyphenolic bioact...

journal_title：Current pharmaceutical design

authors： Nyanhanda T,Gould EM,Hurst RD

更新日期：2014-01-01 00:00:00

abstract：:Subjects affected by ischemic heart disease with non-obstructive coronary arteries constitute a population that has received increasing attention over the past two decades. Since the first studies with coronary angiography, female patients have been reported to have non-obstructive coronary artery disease more frequen...

journal_title：Current pharmaceutical design

authors： Bergami M,Scarpone M,Cenko E,Varotti E,Amaduzzi PL,Manfrini O

更新日期：2020-10-12 00:00:00

abstract：:Inhaled glucocorticoids, also know as corticosteroids (ICS), revolutionized the treatment of asthma by suppressing airways inflammation and ICS therapy now forms the basis of treatment of asthma of all severities. More recently and usually in combination with a long-acting β-agonist (LABA), ICS use has been establishe...

journal_title：Current pharmaceutical design

authors： Adcock IM,Marwick J,Casolari P,Contoli M,Chung KF,Kirkham P,Papi A,Caramori G

更新日期：2010-01-01 00:00:00

abstract：:Emerging evidence has shown that microRNAs (miRNAs) can act as oncogenes in the initiation and progression of leukemia and lymphoma. Aberrant expression of oncogenic miRNAs, including miR-155, miR-17-92, miR-21, miR-125b, miR-93, miR-143-p3, miR-196b, and miR-223 promotes leukemogenesis through increasing the leukemic...

journal_title：Current pharmaceutical design

authors： Pan Y,Meng M,Zhang G,Han H,Zhou Q

更新日期：2014-01-01 00:00:00

abstract：:There is an increasing need to rapidly determine the specificity of proteases that potentially play a role in human and animal disease. Substrates for novel proteases can be discovered by testing standard protease substrates such as oxidized insulin B-chain, by screening commercially available substrates for other pro...

journal_title：Current pharmaceutical design

authors： Richardson PL

更新日期：2002-01-01 00:00:00

abstract：:Adenosine A(2A)-dopamine D(2) receptor interactions play a very important role in striatal function. A(2A)-D(2) receptor interactions provide an example of the capabilities of information processing by just two different G protein-coupled receptors. Thus, there is evidence for the coexistence of two reciprocal antagon...

journal_title：Current pharmaceutical design

authors： Ferré S,Quiroz C,Woods AS,Cunha R,Popoli P,Ciruela F,Lluis C,Franco R,Azdad K,Schiffmann SN

更新日期：2008-01-01 00:00:00

abstract：:Metabolic syndrome (MetS) is a cluster of risk factors, each one individually associated with increased cardiovascular disease risk. Treatment of all components of MetS is expected to result in reduced risk. Treatment of MetS mainly includes lifestyle changes. In addition, drug therapy may be considered, especially co...

journal_title：Current pharmaceutical design

authors： Florentin M,Elisaf MS,Mikhailidis DP,Liberopoulos EN

更新日期：2009-01-01 00:00:00

abstract：:Diterpenes present complex structure and due to their unique carbon skeleton and interesting biological activities, have been the focus of continuous studies for the development of new anticancer agents. Phorbol esters have been known for their activity against skin malignancies since ancient times. Taxol was first st...

journal_title：Current pharmaceutical design

authors： Prieto JM,Silveira D

更新日期：2018-01-01 00:00:00

abstract：:CD1 molecules are a family of non-polymorphic, class I antigen-presenting glycoproteins, which bind and present amphiphilic lipid antigens for recognition to T cells. Two groups of CD1 molecules are involved in presentation of self and foreign lipid antigens: group 1 (CD1a, CD1b and CD1c) and group 2 (CD1d). Crystal s...

journal_title：Current pharmaceutical design

authors： Schiefner A,Wilson IA

更新日期：2009-01-01 00:00:00

abstract：:Hypertension and insomnia are very common and often coexist. There is evidence to suggest that the increasing prevalence of arterial hypertension in the past decade might be related both to an increased prevalence of insomnia and to the decline of sleep duration due to modern lifestyle. The aim of this paper is to rec...

journal_title：Current pharmaceutical design

authors： Palagini L,Bruno RM,Gemignani A,Baglioni C,Ghiadoni L,Riemann D

更新日期：2013-01-01 00:00:00

abstract：:The ever-growing resistance of pathogens to antibiotics and crop disease due to pest has triggered severe health concerns in recent years. Consequently, there is a need of powerful and protective materials for the eradication of diseases. Metal/metal oxide nanoparticles (M/MO NPs) are powerful agents due to their ther...

journal_title：Current pharmaceutical design

authors： Chaudhary RG,Bhusari GS,Tiple AD,Rai AR,Somkuvar SR,Potbhare AK,Lambat TL,Ingle PP,Abdala AA

更新日期：2019-01-01 00:00:00

abstract：Background:Capsinoids (CSN), the novel non-pungent capsaicin analogs have been reported to promote metabolic health and exercise tolerance. However, the effect of CSN on fat oxidation and changes in skeletal muscle glycogen levels during post-exercise recovery has not been investigated in humans. Purpose:We examined t...

journal_title：Current pharmaceutical design

authors： Liao SF,Korivi M,Tsao JP,Huang CC,Chang CC,Cheng IS

更新日期：2020-08-23 00:00:00

abstract：:Topiramate is one of the currently most promising compounds in the field of addiction medicine. This paper discusses its potential utility related to a phase model of addiction development, focusing on the assumption that addiction is a continuous process involving different neurobiological pathways, depending on the ...

journal_title：Current pharmaceutical design

authors： Thorens G,Billieux J,Manghi R,Khan R,Khazaal Y,Zullino DF

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Bacterial cellulose (BC) has recently attained greater interest in various research fields, including drug delivery for biomedical applications. BC has been studied in the field of drug delivery, such as tablet coating, controlled release systems and prodrug design. OBJECTIVE:In the current work, we tested ...

journal_title：Current pharmaceutical design

authors： Ullah H,Badshah M,Correia A,Wahid F,Santos HA,Khan T

更新日期：2019-01-01 00:00:00

abstract：:The frequency of neuropsychiatric disorders is greater than that of cancer, cardiovascular disease, and diabetes combined, and is growing at a faster rate than any other ailments in the United States or Europe. Despite a considerable need for the development of treatments for central nervous system disorders, pharmace...

journal_title：Current pharmaceutical design

authors： Schroeder RA,Wecker L,Philpot RM

更新日期：2016-01-01 00:00:00

abstract：:The number of protein 3D structures without function annotation in Protein Data Bank (PDB) has been steadily increased. Many of these proteins are relevant for Pharmaceutical Design because they may be enzymes of different classes that could become drug targets. This fact has led in turn to an increment of demand for ...

journal_title：Current pharmaceutical design

authors： Concu R,Podda G,Ubeira FM,González-Díaz H

更新日期：2010-01-01 00:00:00

abstract：:The human herpesviruses herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) can cause severe recurrent disease in humans and establish lifelong infection in their hosts. Several antiviral therapies are available to control disease and spread, but these are not completely effective and do not affect latent virus. The ...

journal_title：Current pharmaceutical design

authors： Ramachandran S,Kinchington PR

更新日期：2007-01-01 00:00:00

abstract：:Genetic variation in the receptors and other intracellular targets that mediate the pharmacodynamic effects of drugs can affect therapeutic outcomes. However, at present greater knowledge is available concerning the extent of gene variation in drug metabolizing enzymes that determine drug pharmacokinetics and, in turn...

journal_title：Current pharmaceutical design

authors： Crettol S,Petrovic N,Murray M

更新日期：2010-01-01 00:00:00

abstract：:Increased plasma levels of both leptin and C reactive protein (CRP) have been reported in a number of conditions, including obesity, and have been linked to cardiovascular pathophysiological processes and increased cardiovascular risk; interestingly these two biomarkers appear to be able to reciprocally regulate their...

journal_title：Current pharmaceutical design

authors： Hribal ML,Fiorentino TV,Sesti G

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Psoriasis is an autoimmune disease of the skin with lapsing episodes of hyperkeratosis, irritation and inflammation. Numerous methodologies and utilization of different antipsoriatic drugs with various activity methods and routes of administration have been investigated to treat this terrifying sickness. In ...

journal_title：Current pharmaceutical design

authors： Dadwal A,Mishra N,Narang RK

更新日期：2018-01-01 00:00:00

abstract：:Enkephalins play a great role in management of pain, blood pressure, hypertension and cardiovascular diseases. Enkephalins are short-lived molecules being rapidly hydrolyzed following their synaptic release by enkephalin degrading enzymes. The inhibitors of enkephalin degrading enzymes are able to prolong the duration...

journal_title：Current pharmaceutical design

authors： Khaket TP,Singh J,Attri P,Dhanda S

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Bevacizumab (BVZ) is a recombinant humanized antibody that inhibits the vascular endothelial growth factor A (VEGFA) and is used for the treatment of various types of cancer. BVZ is primarily given by the intravenous drip (I.V.), which often leads to low efficacy and various side effects. There...

journal_title：Current pharmaceutical design

authors： Jiang X,Zhang QL,Liu TG,Zhao WP,Yang M,Wang LN,Sun WL,Pan L,Luo AP,Huang JC,Gu XH

更新日期：2019-01-01 00:00:00

abstract：:Recent progresses in the development of fluorescent technologies become a reliable device for drug discovery research. The fluorescence tools offer attractive options for an opportunity to visualize the effects of drug candidates in the cells. The fluorescent tools, such as fluorescent protein, are regularly used in a...

journal_title：Current pharmaceutical design

authors： Chakraborty C,Hsu CH,Wen ZH,Lin CS

更新日期：2009-01-01 00:00:00

abstract：:Type 2 diabetes is associated with substantially increased cardiovascular mortality. The need to reduce the progression of atherosclerosis alongside lowering blood glucose levels is now well established. Ideally, pharmaceutical treatment should address both of these needs. This review summarises current evidence of th...

journal_title：Current pharmaceutical design

authors： Papanas N,Maltezos E

更新日期：2009-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder characterized by cardinal features of tremor, bradykinesia, rigidity and postural instability. In addition to the motor symptoms patients experience cognitive decline eventually resulting in severe disability. Pathologically PD is characterized by neurode...

journal_title：Current pharmaceutical design

authors： Thomas M,Le WD

更新日期：2004-01-01 00:00:00

abstract：:The role of polyphenols in the cardiovascular diseases prevention is still a matter of scientific discussion. However, recent clinical studies indicate that intake of anthocyanins and in a lesser extent procyanidins can participate in prevention of hypertension and type 2 diabetes. Fruits of Aronia melanocarpa (chokeb...

journal_title：Current pharmaceutical design

authors： Parzonko A,Naruszewicz M

更新日期：2016-01-01 00:00:00