Abstract:
:Dravet syndrome, a severe infantile epilepsy syndrome, is typically resistant to anti-epileptic drugs (AED). Lamotrigine (LTG), an AED that is effective for both focal and generalized seizures, has been reported to aggravate seizures in Dravet syndrome. Therefore, LTG is usually avoided in Dravet syndrome. We describe two adults and a child with Dravet syndrome in whom LTG resulted in decreased seizure duration and frequency. This benefit was highlighted in each patient when LTG was withdrawn after 6 to 15 years, and resulted in an increased frequency of convulsive seizures together with longer seizure duration. A 25-year-old male required hospital admission for frequent seizures for the first time in 7 years, 6 weeks after ceasing LTG. Reintroduction of LTG improved seizure control, suggesting that in some patients with Dravet syndrome, LTG may be beneficial.
journal_name
Dev Med Child Neuroljournal_title
Developmental medicine and child neurologyauthors
Dalic L,Mullen SA,Roulet Perez E,Scheffer Idoi
10.1111/dmcn.12593subject
Has Abstractpub_date
2015-02-01 00:00:00pages
200-2issue
2eissn
0012-1622issn
1469-8749journal_volume
57pub_type
杂志文章abstract::Minor neurological dysfunction (MND) and quality of movement were studied in relation to neonatal cerebral damage and developmental assessments at 3 1/2 years of age in 66 very low-birthweight children without obvious disability. MND was found in 19 children and was significantly related to the quality of movement. Th...
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journal_title:Developmental medicine and child neurology
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