Lamotrigine can be beneficial in patients with Dravet syndrome.

Abstract:

:Dravet syndrome, a severe infantile epilepsy syndrome, is typically resistant to anti-epileptic drugs (AED). Lamotrigine (LTG), an AED that is effective for both focal and generalized seizures, has been reported to aggravate seizures in Dravet syndrome. Therefore, LTG is usually avoided in Dravet syndrome. We describe two adults and a child with Dravet syndrome in whom LTG resulted in decreased seizure duration and frequency. This benefit was highlighted in each patient when LTG was withdrawn after 6 to 15 years, and resulted in an increased frequency of convulsive seizures together with longer seizure duration. A 25-year-old male required hospital admission for frequent seizures for the first time in 7 years, 6 weeks after ceasing LTG. Reintroduction of LTG improved seizure control, suggesting that in some patients with Dravet syndrome, LTG may be beneficial.

journal_name

Dev Med Child Neurol

authors

Dalic L,Mullen SA,Roulet Perez E,Scheffer I

doi

10.1111/dmcn.12593

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

200-2

issue

2

eissn

0012-1622

issn

1469-8749

journal_volume

57

pub_type

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