Abstract:
:Individuals with congenital adrenal hyperplasia (CAH) provide a test population for the theory that elevated testosterone levels alter prenatal brain development and increase the risk of learning disabilities. Eleven subjects with CAH, five of their non-CAH siblings and 16 matched control subjects participated in two studies. The first study documented hand preference, verbal skills and non-verbal skills. A higher prevalence of language/learning disability was found in both the CAH subjects and their families than in the control subjects. The second study examined the prevalence of atypical perisylvian asymmetries on MRI scans. These revealed an atypical pattern of asymmetry (R = L or R > L) in the majority of the subjects with CAH and in all of their siblings. One subject with CAH also showed evidence of a neuromigratory disturbance in the posterior left hemisphere. Of the control subjects, only one showed an atypical pattern of asymmetry and none showed evidence of a neuromigratory disorder. The findings indicate that an elevated familial rate for language-based learning disabilities and altered brain asymmetries co-occur in families with the gene for CAH.
journal_name
Dev Med Child Neuroljournal_title
Developmental medicine and child neurologyauthors
Plante E,Boliek C,Binkiewicz A,Erly WKdoi
10.1111/j.1469-8749.1996.tb15100.xsubject
Has Abstractpub_date
1996-05-01 00:00:00pages
423-37issue
5eissn
0012-1622issn
1469-8749journal_volume
38pub_type
杂志文章abstract::Periventricular nodular heterotopia (PNH) is a rare neuronal migration disorder in which immature neurons fail to undergo a directed migration from the ventricular and subventricular zones to the cerebral cortex. Classic PNH occurs predominantly in females and is associated with periods of epilepsy and near-normal int...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.2007.00219.x
更新日期:2007-03-01 00:00:00
abstract:AIM:To determine the association between sucking in infants born preterm and developmental outcomes at 5 years. METHOD:Thirty-four infants were included (mean gestational age 30wks 4d, mean birthweight 1407g). The Neonatal Oral-Motor Assessment Scale was used longitudinally from 37 to 50 weeks postmenstrual age. At 5 ...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/dmcn.13438
更新日期:2017-08-01 00:00:00
abstract:AIM:To explore cortical activation during bimanual tasks and functional correlates in unilateral cerebral palsy (CP). METHOD:This cross-sectional study included eight participants with unilateral CP (six females, two males; mean age [SD] 20y 10mo [5y 10mo], 13y 8mo-31y 6mo) in Manual Ability Classification System leve...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/dmcn.14458
更新日期:2020-05-01 00:00:00
abstract:AIM:to identify the use and utility of language comprehension tests for unintelligible or non-speaking children with severe cerebral palsy (CP). METHOD:severe CP was defined as severe dysarthria (unintelligible speech) or anarthria (absence of speech) combined with severe limited mobility, corresponding to Gross Motor...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章,评审
doi:10.1111/j.1469-8749.2010.03807.x
更新日期:2010-12-01 00:00:00
abstract::Three cases of 'vertical' hydrocephalus are described, characterised by absence of the bones of the skull vault, progressive vertical soft-tissue growth of the head, and normal occipito-frontal head circumference. The management of the condition by ventriculo-peritoneal shunt is discussed, and a theory proposed as to ...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1979.tb01657.x
更新日期:1979-08-01 00:00:00
abstract::Anthropometric data were collected on groups of seven-year-old Dunedin (New Zealand) boys, identified as hyperactive-only, aggressive-hyperactive, aggressive-only and non-aggressive/non-hyperactive. Measures taken included stature, weight, skeletal maturity, mid-upper arm circumference, triceps and subscapular fatfold...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1985.tb04548.x
更新日期:1985-06-01 00:00:00
abstract::Fourteen ambulatory children with spastic diplegia participated in a bilateral quadriceps strengthening program in an attempt to decrease the amount of knee crouch during gait. Each child exercised three times a week for six weeks using free ankle weights at a load of 65 per cent of maximum. A normal comparison group ...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1995.tb15019.x
更新日期:1995-08-01 00:00:00
abstract::This case series describes three children with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS), an inflammatory condition characterized by a relapsing-remitting disease course responsive to steroids. The patients (two males, age 3y and 13y; one female, age 14y) ...
journal_title:Developmental medicine and child neurology
pub_type:
doi:10.1111/dmcn.13997
更新日期:2019-04-01 00:00:00
abstract::Twenty-three Swedish children aged five to 18 years who fulfilled specific criteria for Asperger syndrome were examined and compared with an age- and IQ-matched group with infantile autism. The boy:girl ratio was 10:1. Less than 10 per cent were mentally retarded and 17 per cent were of above-average intelligence. Apa...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章,评审
doi:10.1111/j.1469-8749.1989.tb04031.x
更新日期:1989-08-01 00:00:00
abstract::The authors report the results of two EEG studies on adult patients with phenylketonuria (PKU) who had been treated early. Part I: the authors followed the EEGs of 34 PKU patients from birth to age 21. The frequency of abnormal EEG findings (especially epileptiform activity) steadily increased until age 12, then decre...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1993.tb11552.x
更新日期:1993-01-01 00:00:00
abstract:AIM:The aim of this study was to compare the approximate number system acuity in children born extremely preterm aged 6 years 6 months and typically developing, age-matched peers. METHOD:This population-based follow-up study included 65 children born before 27 gestational weeks (35 males, 30 females; mean gestational ...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/dmcn.12206
更新日期:2013-12-01 00:00:00
abstract::Epilepsy has a significant impact on a child's life, the extent to which is based on four factors: epilepsy, cognition, behavioral, and physical/neurologic function. This study evaluates the ability of the 44-item Impact of Childhood Neurologic Disability Scale (ICND) to assess each of these four realms. Parents of ch...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1017/s0012162203000306
更新日期:2003-03-01 00:00:00
abstract:AIM:Optimizing movement quality is a common rehabilitation goal for children with cerebral palsy (CP). The new Quality Function Measure (QFM)--a revision of the Gross Motor Performance Measure (GMPM)--evaluates five attributes: Alignment, Co-ordination, Dissociated movement, Stability, and Weight-shift, for the Gross M...
journal_title:Developmental medicine and child neurology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/dmcn.12453
更新日期:2014-08-01 00:00:00
abstract::The importance of the family environment for the development of children with neurodisabilities is undisputed. The objective of this study is to describe how family environment has been measured in research on families of children with neurodisabilities, in order to support researchers and clinicians to select appropr...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章,评审
doi:10.1111/dmcn.13287
更新日期:2017-03-01 00:00:00
abstract::The authors looked for differences in the energy expenditure patterns of ambulant children with cerebral palsy and spina bifida. Oxygen consumption was measured according to type of cerebral palsy or level of spina bifida lesion, and in healthy children. The rate of oxygen consumption (mL/kg/min) was significantly hig...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1996.tb15085.x
更新日期:1996-03-01 00:00:00
abstract::The neurodevelopmental status of 171 very preterm infants whose brains had been scanned prospectively with ultrasound was assessed blind at four years using a wide range of tests, including tests of cognitive function. Highly significant correlations were found between the ultrasound appearance of the brain and outcom...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1988.tb14633.x
更新日期:1988-12-01 00:00:00
abstract:AIM:To assess outcome for children with severe neurological impairment receiving invasive mechanical ventilation for respiratory failure. METHOD:Medical charts for all such children treated in our intensive care unit (ICU) between January 2003 and July 2008 were reviewed. Outcomes were compared with those for children...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.2009.03582.x
更新日期:2010-05-01 00:00:00
abstract::Surface electromyography and accelerometry provide essential information on the neurophysiological characteristics of essential tremor. There are many reports on neurophysiological features in adult-onset essential tremor, but to our knowledge there have been no similar investigations of essential tremor in children. ...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1017/s0012162203001130
更新日期:2003-09-01 00:00:00
abstract::A large New England family with autosomal dominant familial spastic paraplegia (ADFSP) is described. In a pedigree of 173 family members, 71 affected individuals were identified. 16 cases examined by the authors are described with regard to the natural history of ADFSP in this family, and a staging system for followin...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1990.tb08530.x
更新日期:1990-12-01 00:00:00
abstract::Maintenance of postural balance requires an active sensorimotor control system. Current data are limited and sometimes conflicting regarding the influence of the proprioceptive, visual, and vestibular afferent systems on posture control in children. This study investigated the development of sensory organization accor...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1017/S0012162206001022
更新日期:2006-06-01 00:00:00
abstract::A 14-month-old girl presented after 3 days of fever, floppiness, and diffuse urticarial exanthem. She developed encephalitis and carditis and 1 week later, intractable seizures. Initial CT and MRI showed no changes in the brain parenchyma. On days 14 and 34 after the onset of symptoms, a human herpesvirus-6 (HHV-6) ge...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1017/s0012162200000773
更新日期:2000-06-01 00:00:00
abstract::This study assessed stability of measurement of quality of life (QOL) and health-related quality of life (HRQOL) over the course of 1 year among 185 adolescents (mean age 16y, SD 1 y 9 mo) with cerebral palsy (CP). Participants were classified on the Gross Motor Function Classification System as level I (n=55), II (n=...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.2008.03053.x
更新日期:2008-09-01 00:00:00
abstract:AIM:Dodd's Model for Differential Diagnosis is one of the available clinical diagnostic classification systems of childhood speech sound disorders. Yet we do not understand the validity of this system beyond clinical samples, precluding its application in epidemiological or population-based research. This study aimed t...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/dmcn.13993
更新日期:2019-06-01 00:00:00
abstract::Two male patients (a child and an adult) with congenital mirror movement were studied using functional MRI (fMRI) and transcranial magnetic stimulation (TMS). Bilateral primary sensorimotor cortices were activated during unilateral hand gripping on fMRI when the child patient was 8 years old andthe adult was 37 years ...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1017/s0012162201003012
更新日期:2002-12-01 00:00:00
abstract::Background factors of developmental outcome in a group of 386 neonatal 'at-risk' infants and 107 controls were examined in a prospective nine-year follow-up study. Dichotomized outcome variables were computed for each of the assessments; neurodevelopmental, motor, psycholinguistic, cognitive and school progress. In th...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1988.tb04795.x
更新日期:1988-10-01 00:00:00
abstract::A 13-year-old boy with Hodgkin's disease developed acute polyneuropathy and autoimmune hemolytic anemia. Sural nerve biopsy and postmortem examination demonstrated no metastatic involvement and a lack of cellular inflammatory infiltration in the nervous system. There was significant axonal degeneration in peripheral n...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1980.tb04329.x
更新日期:1980-04-01 00:00:00
abstract::The aim of this study was to investigate the association between epilepsy and perinatal brain injury in a cohort of 610 infants born preterm at <33 weeks' gestation. The prevalence of epilepsy in this cohort was 4.3% as determined by a postal questionnaire survey. Most children with epilepsy (16 of 24) had high-risk c...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1998.tb12339.x
更新日期:1998-11-01 00:00:00
abstract::Four infants were studied who failed to show any visual interest or following responses in the first three months of life. Although no definite ocular abnormalities were found at the time of presentation, both the parents and their medical advisers initially had serious concerns about the infants' visual prognosis. In...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1980.tb03712.x
更新日期:1980-06-01 00:00:00
abstract:AIM:Botulinum toxin type A (BoNT-A) injections were used in the treatment of lower-limb spasticity in children with cerebral palsy (CP). Anecdotal evidence suggests a reduction in pain after this treatment in children who had pain localized to a displaced hip joint. We report on our current clinical practice. METHOD:T...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.2009.03315.x
更新日期:2009-09-01 00:00:00
abstract::A neurodevelopmental screening test with cumulative scoring for abnormal test responses was performed on 845 five-year-old Finnish children who, in the newborn period, had had disorders which placed them in a high-risk group, and on 70 controls. The results showed a significant difference between the neurodevelopmenta...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1981.tb02015.x
更新日期:1981-08-01 00:00:00