Abstract:
:A 14-month-old girl presented after 3 days of fever, floppiness, and diffuse urticarial exanthem. She developed encephalitis and carditis and 1 week later, intractable seizures. Initial CT and MRI showed no changes in the brain parenchyma. On days 14 and 34 after the onset of symptoms, a human herpesvirus-6 (HHV-6) genome in cerebrospinal fluid was identified by polymerase chain reaction (PCR). Convulsions became more frequent and 11 weeks from the onset, they changed to typical infantile spasms with hypsarrhythmic electroencephalogram. She gradually lost her social contact and ability to walk and sit. Eleven months after the primary infection, a repeated MRI of the brain revealed a cystic tumour of 2 cm in diameter near the vermis. The tumour was surgically removed, and shown to be a pilocytic astrocytoma on histopathological examination. HHV-6 DNA was detected by PCR in new tumour tissue. This is the first reported case of HHV-6 encephalitis associated with carditis, infantile spasms, and a subsequent brain tumour containing the HHV-6 genome.
journal_name
Dev Med Child Neuroljournal_title
Developmental medicine and child neurologyauthors
Rantala H,Mannonen L,Ahtiluoto S,Linnavuori K,Herva R,Vaheri A,Koskiniemi Mdoi
10.1017/s0012162200000773subject
Has Abstractpub_date
2000-06-01 00:00:00pages
418-21issue
6eissn
0012-1622issn
1469-8749journal_volume
42pub_type
杂志文章abstract:AIM:The aim of this study was to assess the role of disability and victimization in young people's participation in developmentally salient activities by analyzing a nationally representative group of young people from the child welfare system (CWS). METHOD:Data were obtained from interviews with young people and thei...
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