Abstract：
:Penetration of 2,4,5,2',4',5'-[14C]hexachlorobiphenyl (HCB) through skin of young (33 days) and adult (82 days) female Fischer 344 rats was determined in vivo and by two in vitro methods. In vivo dermal penetration at 120 hr was 45% in young and 43% in adults. At 72 hr in vivo dermal penetration was 35% in young and 26% in adults compared to 1.5% for young and 1.0% for adult as measured with a continuous flow in vitro system and 2.9% for young and 1.9% for adults as measured with a static in vitro system. Most of the dermally absorbed HCB remained in the body as only 4.9 and 2.6% of that absorbed was excreted by young and adult rats, respectively, at the end of 120 hr. Significant differences in dermal penetration and kinetics of HCB between young and adult female rats were observed. The elimination of HCB-derived material was approximately six times higher in feces than in urine. A physiological pharmacokinetic model was fitted to the organ and tissue radioactivity distribution data. Parameters in the model determined from dermal dosing of female Fischer 344 rats were in reasonable agreement with those reported in the literature for adult male Sprague-Dawley rats (iv dose). The rat constant for dermal penetration was 0.83 x 10(-4) min-1 for adults and 0.96 x 10(-4)min-1 for young. The delay or lag time parameter for dermal penetration was 4.4 hr in adults and 1.1 hr in young.
journal_name
Environ Resjournal_title
Environmental researchauthors
Fisher HL,Shah PV,Sumler MR,Hall LLdoi
10.1016/s0013-9351(89)80053-2subject
Has Abstractpub_date
1989-10-01 00:00:00pages
120-39issue
1eissn
0013-9351issn
1096-0953pii
S0013-9351(89)80053-2journal_volume
50pub_type
杂志文章abstract：BACKGROUND:Dichlorodiphenyl dichloroethylene (DDE) and polychlorinated biphenyls (PCBs) can be passed from mother to offspring through placental transfer or breastfeeding. Unknown is whether maternal levels can predict concentrations in adult offspring. OBJECTIVES:To test the association between maternal blood levels ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2014.03.009
更新日期：2014-07-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
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更新日期：2017-10-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.11.042
更新日期：2018-02-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.1997.3804
更新日期：1998-05-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：Environmental research
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更新日期：2020-09-01 00:00:00
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journal_title：Environmental research
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更新日期：2019-04-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章,meta分析
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更新日期：2020-11-01 00:00:00
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journal_title：Environmental research
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更新日期：2020-08-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.1994.1014
更新日期：1994-02-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
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更新日期：2019-06-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2012.10.003
更新日期：2013-02-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2016.01.003
更新日期：2016-04-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2015.10.007
更新日期：2015-11-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2014.12.029
更新日期：2015-05-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.2002.4384
更新日期：2002-09-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章,评审
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更新日期：2010-11-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2016.11.010
更新日期：2017-02-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章,评审
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更新日期：2020-02-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(88)80010-0
更新日期：1988-02-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(05)80094-5
更新日期：1991-04-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
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更新日期：2019-12-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
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更新日期：2020-03-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
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更新日期：2014-05-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2006.11.010
更新日期：2007-10-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.108576
更新日期：2019-09-01 00:00:00
abstract：:The development of new photocatalyst towards the highly efficient photo-reduction of U(VI) was highly desirable. In this study, ZIF-8/g-C3N4 photocatalyst was fabricated to photo-reduce U(VI) from aqueous solutions under different water chemistry. It is demonstrated that ZIF-8/g-C3N4 exhibited the fast-photocatalytic ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110349
更新日期：2020-10-28 00:00:00
