Abstract:
:Complexation of ferrous cytochrome P450 by metabolic intermediates formed during NADPH-catalyzed metabolism of compounds structurally related to orphenadrine was studied. This so-called metabolic intermediate complexation was determined in rat liver microsomes, obtained from phenobarbital-pretreated rats, at 455 nm using 33 microM of the orphenadrine derivatives. Using secondary amine derivatives with various N-alkyl substituents, a parabolic relationship between the logarithm of percentage of cytochrome P450 complexation and hydrophobic fragmental constant was observed. The derivative with a bulky tertiary butyl group, however, was devoid of metabolic intermediate-complexing activity. This indicates that steric factors besides lipid solubility may govern the complexing activity; also substitution at the phenyl group affects metabolic intermediate complex formation.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Bast A,Savenije-Chapel EM,Noordhoek Jdoi
10.1002/jps.2600730723subject
Has Abstractpub_date
1984-07-01 00:00:00pages
953-6issue
7eissn
0022-3549issn
1520-6017pii
S0022-3549(15)46225-2journal_volume
73pub_type
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journal_title:Journal of pharmaceutical sciences
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