当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN GERIATRICS SOCIETY期刊下所有文献 > Review of genetic investigations into the aging processes of Drosophila.

Review of genetic investigations into the aging processes of Drosophila.

Abstract：

:The field has progressed to the point where a genetic investigation of the aging processes in Drosophila can be viewed as constituting both a serious and a feasible research program. There now exists at least one single gene mutant which yields an accelerated aging phenotype, at least two single gene null mutants affecting enzymes implicated in regulating the aging process and resulting in premature death, and at least two strains created by artificial selection which produce extended-longevity phenotypes. In addition, genes such as adh have an indirect and interactive effect upon the animal's longevity and might also play an important role in the genetic regulation of this process. Although far from complete, some essential tools are now in place and are being used to answer some of the questions posed by Martin. Of the several theories put forth to explain aging in Drosophila, it appears as if the data best uphold the free radical and the protein synthesis/gene expression theories. It is entirely possible that these two theories are complementary aspects of a broader underlying process. The genetic mechanisms controlling these physiological processes clearly do so in concert with certain environmental factors. The net effect of their interactions may be the decreased synthetic and repair ability of the cell as suggested by Lamb and by Webster. It is probably true that aging and longevity are multicausal phenotypes. Our only hope of understanding such a complex phenotype is to dissect it genetically, one (or a few) genes at a time under rigidly controlled conditions. Thorough genetic description of each system will be the prerequisite to their molecular analysis. This will likely result in multiple explanations, ideally one for each system. Yet these multiple molecular genetic explanations may well enable us to see some commonality underlying the aging process in this organism. The fact that several different lines of evidence appear to be converging on a small number of theoretical explanations is an encouraging sign. We should also be heartened by the extraordinary increase in our knowledge of embryonic development in Drosophila as a result of just such a strategy. And we should not forget that the homeotic mutants which now play such a large role in the deciphering of embryogenesis were once classified as "complex loci" and that the then-accepted explanations gave no hint of the underlying molecular relationships. For now it is fair to conclude that aging in Drosophila may be viewed as a genetically-determined, environmentally-modulated, event-dependent process.(ABSTRACT TRUNCATED AT 400 WORDS)

journal_name

J Am Geriatr Soc

journal_title

Journal of the American Geriatrics Society

authors

Arking R,Dudas SP

doi

10.1111/j.1532-5415.1989.tb02240.x

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

757-73

issue

eissn

0002-8614

issn

1532-5415

journal_volume

pub_type

杂志文章,评审

在线工具

Review of genetic investigations into the aging processes of Drosophila.