Abstract：
:The immune status of 17 healthy individuals 100-103 years of age (centenarians) was investigated. Qualitative values for immunoglobulins IgG, IgM, IgA, and IgE were within normal ranges for subjects more than 60 years of age with the exception of elevated IgM in one individual. Cell marker studies employing a panel of 27 monoclonal antibodies delineating T and B lymphocytes, monocytes, natural killer cells, granulocytes, and functional and developmental subsets of each were performed to phenotype the peripheral blood leukocytes. Although the total lymphocyte count was normal in every subject, the numbers of T4-positive helper-inducer T lymphocytes were profoundly depressed, as were responses to the mitogen phytohemagglutinin and interleukin-2 production. Activated immature T lymphocytes and the number of cells bearing the phenotype of natural killer cells were increased, but natural killer cell activity was normal. Early B lymphocytes were also increased. The relative concentration of monocytes was normal. Taken together these findings indicate that the immune system in centenarians is similar to that in younger but still elderly individuals, i.e., discriminating T-lymphoid functions are reduced in association with an apparent failure of some T, B, and natural killer cells to differentiate to functional maturity.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Thompson JS,Wekstein DR,Rhoades JL,Kirkpatrick C,Brown SA,Roszman T,Straus R,Tietz Ndoi
10.1111/j.1532-5415.1984.tb02021.xsubject
Has Abstractpub_date
1984-04-01 00:00:00pages
274-81issue
4eissn
0002-8614issn
1532-5415journal_volume
32pub_type
杂志文章abstract：OBJECTIVES:To determine whether cognitive test scores and cognitive decline predict incidence of first diagnosed stroke. DESIGN:Stroke-free Health and Retirement Study participants were followed on average 7.6 years for self- or proxy-reported first stroke (1,483 events). Predictors included baseline performance on a ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2008.02132.x
更新日期：2009-03-01 00:00:00
abstract：OBJECTIVES:The Centers for Medicare & Medicaid Services (CMS) Nursing Home Quality Initiative aims to improve quality through performance measurement. We describe quality improvement (QI) changes that skilled nursing facilities (SNFs) reported making in response to CMS performance measurements and whether reported QI c...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.16466
更新日期：2020-09-01 00:00:00
abstract：:Ninety-three consecutive outpatients receiving tricyclic antidepressants for at least one month were asked about medication side effects, including excessive appetite and craving for sweets. Prevalence of these side effects and their relationship (Pearson r) to type of medication, dosage, patient characteristics, diag...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1985.tb01777.x
更新日期：1985-10-01 00:00:00
abstract：:Despite concerted effort to rehabilitate and return patients to their homes, the majority of nursing home patients are destined to spend the remainder of their days in institutional settings. These custodial care patients are elderly, have many functional disabilities, and are often demented. The traditional medical a...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1985.tb05442.x
更新日期：1985-12-01 00:00:00
abstract：OBJECTIVES:To test for simvastatin-induced changes in affect and affective processes in elderly volunteers. DESIGN:Randomized, clinical trial. SETTING:The Geriatric Behavioral Psychopharmacology Laboratory at the University of Pennsylvania. PARTICIPANTS:Eighty older volunteers, average age 70, with high normal/mildl...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1532-5415.2005.00542.x
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVES:To evaluate the association between pressure-redistributing support surface (PRSS) use and incident pressure ulcers in older adults with hip fracture. DESIGN:Secondary analysis of data from prospective cohort with assessments performed as soon as possible after hospital admission and on alternating days for...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2011.03446.x
更新日期：2011-06-01 00:00:00
abstract：:Now that the benefits of treating diastolic hypertension in the elderly have been convincingly proved, attention is turning to the need for, and the choice of, treatment of isolated systolic hypertension in this age group. The hemodynamic mechanism differs in the elderly, whose isolated systolic hypertension is likely...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1986.tb05477.x
更新日期：1986-02-01 00:00:00
abstract：OBJECTIVES:To characterize emergency department (ED) use by nursing home residents in the United States. DESIGN:Analysis of the National Hospital Ambulatory Medical Care Survey. SETTING:U.S. EDs from 2005 to 2008. PARTICIPANTS:Individuals visiting U.S. EDs stratified according to nursing home residency. MEASUREMENT...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2011.03587.x
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVES:To evaluate the effect of medical Primary Integrated Interdisciplinary Elder Care at Home (PIECH) on acute hospital use and mortality in a frail elderly population. DESIGN:Comparison of acute hospital care use for the year before entering the practice (pre-entry) with the most-recent 12-month period (May 1,...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2012.03965.x
更新日期：2012-07-01 00:00:00
abstract：:The Physician Orders for Life-Sustaining Treatment (POLST) form is a palliative care tool that contains standardized, actionable medical orders. It is designed to ensure that patient treatment preferences are elicited, communicated, and honored throughout the healthcare system. A systematic review of the literature wa...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,评审
doi：10.1111/jgs.13248
更新日期：2015-02-01 00:00:00
abstract：OBJECTIVES:To identify valid tools to diagnose delirium superimposed on dementia. DESIGN:Systematic review of studies of delirium tools that explicitly included individuals with dementia. SETTING:Hospital. PARTICIPANTS:Studies were included if delirium assessment tools were validated against standard criteria, and t...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,评审
doi：10.1111/j.1532-5415.2012.04199.x
更新日期：2012-11-01 00:00:00
abstract：OBJECTIVES:Heart failure is a major health care burden among older adults, but information on recent trends has not been available. We compare rates, sociodemographic characteristics, and discharge outcomes of the initial hospitalization for heart failure in the Medicare populations of 1986 and 1993. DESIGN:Informatio...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1997.tb00939.x
更新日期：1997-03-01 00:00:00
abstract：:The GRECC program was established by the VA in 1975 and has been expanded since then to 16 sites. For more than a decade, GRECC staff have made major contributions to advancing the understanding of the aging process and developing approaches that have improved the care of older veterans as well as all frail elderly pe...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1994.tb06599.x
更新日期：1994-09-01 00:00:00
abstract：BACKGROUND:The impact of parkinsonism on survival in older persons independent of dementia is not well understood. METHODS:Participants in the clinical examination of the Canadian Study of Health and Aging who had parkinsonism and were older than age 65 were identified. The impact of parkinsonism on 5-year survival wa...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2000.tb04701.x
更新日期：2000-04-01 00:00:00
abstract：:Logical bases (five of which are outlined) underlie action in nutrition and aging. First, nutrition, health, and aging form an integral triad affecting all. This basis has been applied to the conceptualization of the Nutrition Program for Older Americans (NPOA). Second, in North America, malnutrition is a sequitur of ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1978.tb01958.x
更新日期：1978-05-01 00:00:00
abstract：OBJECTIVES:To determine if aging modifies the clinical presentation of hyperthyroidism and the signs of thyrotoxicosis in older people. DESIGN:Prospective cohort study. SETTING:A French university hospital. SUBJECTS:Eighty-four new patients with overt hyperthyroidism confirmed chemically between January 1992 and Jan...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1996.tb05637.x
更新日期：1996-01-01 00:00:00
abstract：OBJECTIVES:To investigate the relationship between total estradiol (E2) levels and 9-year mortality in older postmenopausal women not taking hormone replacement therapy (HRT). DESIGN:Population-based study of persons living in the Chianti geographic area (Tuscany, Italy). SETTING:Community. PARTICIPANTS:A representa...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2009.02464.x
更新日期：2009-10-01 00:00:00
abstract：OBJECTIVES:To determine the association between complementary and alternative medicine (CAM) use and antihypertensive medication adherence in older black and white adults. DESIGN:Cross-sectional. SETTING:Patients enrolled in a managed care organization. PARTICIPANTS:Two thousand were hundred eighty black and white a...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2009.02639.x
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVES:To determine the effectiveness of a behavior change intervention (BCI) with or without a pedometer in increasing physical activity in sedentary older women. DESIGN:Prospective randomized controlled trial. SETTING:Primary care, City of Dundee, Scotland. PARTICIPANTS:Two hundred four sedentary women aged 70...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1532-5415.2010.03127.x
更新日期：2010-11-01 00:00:00
abstract：OBJECTIVES:To assess the efficacy of a leg exercise performed in supine position to prevent orthostatic hypotension (OH) in older adults. DESIGN:Case-control study. SETTING:Division of Physical Medicine and Rehabilitation, Salvatore Maugeri Foundation, Scientific Institute of Veruno, Veruno, Italy. PARTICIPANTS:Indi...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.12313
更新日期：2013-07-01 00:00:00
abstract：OBJECTIVES:To investigate whether changes in death certificate coding and reporting practices explain part or all of the recent increase in the rate of fatal falls in adults aged 65 and older in the United States. DESIGN:Trends in coding and reporting practices of fatal falls were evaluated under mortality coding sche...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.13591
更新日期：2015-09-01 00:00:00
abstract：:Medication errors and adverse drug events are common in older adults, but locating literature addressing these issues is often challenging. The objective of this article is to summarize recent studies addressing medication errors and adverse drug events in a single location to improve accessibility for individuals wor...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,评审
doi：10.1111/jgs.13922
更新日期：2016-02-01 00:00:00
abstract：:As life expectancy increases, so do the problems of the elderly population. One major problem is that of protein calorie malnutrition; another is the susceptibility of this population to pressure sores. The purpose of this study was to determine if a correlation exists between deteriorating nutritional status and the ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1986.tb03411.x
更新日期：1986-06-01 00:00:00
abstract：OBJECTIVE:To create a program to identify preventive needs for community-dwelling older persons and incorporate intervention strategies to improve implementation of these services. DESIGN:Program development and case-series. SETTING:Community-based meal sites, academically administered program. PARTICIPANTS:Persons ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1996.tb01416.x
更新日期：1996-11-01 00:00:00
abstract：BACKGROUND:Coronary artery calcification (CAC) reflects the extent of coronary artery atherosclerosis. The extent of coronary artery calcification is not well described in older adults. OBJECTIVE:To determine the extent of CAC in older adults participating in a large population study of cardiovascular disease (CVD), e...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2000.tb02643.x
更新日期：2000-03-01 00:00:00
abstract：:The Geriatric Pharmacy elective course at the University of Kentucky College of Pharmacy uses a simulated medication adherence project to increase awareness of adherence concerns facing older adults who take multiple medications. This study evaluated the effect of this project. Students enrolled in this 3-credit hour ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2009.02364.x
更新日期：2009-08-01 00:00:00
abstract：OBJECTIVES:To develop a reliable and valid dementia knowledge scale to address limitations of existing measures, support knowledge evaluation in diverse populations, and inform educational intervention development. DESIGN:A five-stage, systematic scale development process was employed to construct and assess the psych...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.13707
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVES:To identify fracture types in a series of older adults with pelvic fractures and to determine whether the type of pelvic fracture affected short-term outcomes and morbidity. DESIGN:Retrospective chart review. SETTING:Teaching hospital. PARTICIPANTS:One hundred eighty-one individuals aged 65 and older with...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2011.03455.x
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVE:To determine the association between kyphosis (degree of forward curvature of the thoracic spine) and measures of spinal osteoporosis (height loss and vertebral fractures) and chronic back pain and disability in older women. DESIGN:A cross-sectional study. SETTING:Eleven clinical centers in the United State...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1997.tb01470.x
更新日期：1997-06-01 00:00:00
abstract：OBJECTIVE:To examine the relationship between restraint use and falls while controlling for the effect of psychoactive drug use among nursing home residents, including subgroups of nursing home residents with high rates of restraint use and/or falls. DESIGN:Secondary analysis of data from a longitudinal clinical trial...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1532-5415.1996.tb01822.x
更新日期：1996-06-01 00:00:00
