Abstract：
OBJECTIVES:To examine the effect of interventions to optimize medication use on adverse drug reactions (ADRs) in older adults. DESIGN:Systematic review and meta-analysis. EMBASE, PubMed, OVID, Cochrane Library, Clinicaltrials.gov, and Google Scholar were searched through April 30, 2017. SETTING:Randomized controlled trials. PARTICIPANTS:Older adults (mean age ≥65) taking medications. MEASUREMENTS:Two authors independently extracted relevant information and assessed studies for risk of bias. Discrepancies were resolved in consensus meetings. The outcomes were any and serious ADRs. Random-effects models were used to combine the results of multiple studies and create summary estimates. RESULTS:Thirteen randomized controlled trials involving 6,198 older adults were included. The studies employed a number of different interventions that were categorized as pharmacist-led interventions (8 studies), other health professional-led interventions (3 studies), a brief educational session (1 study), and a technology intervention (1 study). The intervention group was 21% less likely than the control group to experience any ADR (odds ratio (OR) = 0.79, 95% confidence interval (CI) = 0.62-0.99). In the six studies that examined serious ADRs, the intervention group was 36% less likely than the control group to experience a serious ADR (OR = 0.64, 95% CI = 0.42-0.98). CONCLUSION:Interventions designed to optimize medication use reduced the risk of any and serious ADRs in older adults. Implementation of these successful interventions in healthcare systems may improve medication safety in older adults.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Gray SL,Hart LA,Perera S,Semla TP,Schmader KE,Hanlon JTdoi
10.1111/jgs.15195subject
Has Abstractpub_date
2018-02-01 00:00:00pages
282-288issue
2eissn
0002-8614issn
1532-5415journal_volume
66pub_type
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journal_title：Journal of the American Geriatrics Society
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journal_title：Journal of the American Geriatrics Society
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abstract：BACKGROUND/OBJECTIVES:The extent to which the prevalence of muscle weakness in the US population varies by different putative grip strength constructs developed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) has not been described. DESIGN:Cross-sectional analysis. SETTING:Two nationally representative c...
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journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2000.tb04746.x
更新日期：2000-07-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Recently revised vaccination recommendations for US adults, aged 65 years and older, include both 23-valent pneumococcal polysaccharide vaccine (PPSV23) and 13-valent pneumococcal conjugate vaccine (PCV13), with PCV13 now recommended for immunocompetent older people based on shared decision making...
journal_title：Journal of the American Geriatrics Society
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journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1999.tb02571.x
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abstract：:The incidence, ecology, and mortality of gram-negative bacillary bacteremia in elderly patients were studied in an analysis of 334 episodes over a four-year-period in a 489-bed North Carolina community teaching hospital, 135 (40.4%) of which occurred in patients 70 years of age or older. The bacteremia rate per 1000 h...
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doi：10.1111/j.1532-5415.1987.tb02311.x
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abstract：OBJECTIVE:To evaluate the use of pentoxifylline to treat impotence in men with mild to moderate penile vascular insufficiency. DESIGN:Double-blind randomized clinical trial. SETTING:Sexual Dysfunction Clinic at VA Medical Center, Sepulveda, CA. PARTICIPANTS:Convenience sample of couples. INTERVENTION:Twelve weeks o...
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pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1532-5415.1993.tb06941.x
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abstract：:The authors compared the demographic and clinical characteristics and treatment recommendations for elderly (greater than or equal to 60 years) and younger patients (17 to 59 years) seen for an emergency psychiatric consultation in a teaching general hospital. Findings revealed 11 distinctive characteristics that diff...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1986.tb05474.x
更新日期：1986-02-01 00:00:00
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journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,评审
doi：10.1111/j.1532-5415.1995.tb07059.x
更新日期：1995-07-01 00:00:00
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journal_title：Journal of the American Geriatrics Society
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doi：10.1111/j.1532-5415.1999.tb03843.x
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journal_title：Journal of the American Geriatrics Society
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更新日期：2003-12-01 00:00:00
abstract：OBJECTIVES:To characterize illness and identify the etiology for two nursing home outbreaks of respiratory illness. DESIGN:Multisite outbreak investigations; cohort. SETTING:Two nursing homes in Pennsylvania. PARTICIPANTS:Facility A residents (n = 170), Facility B residents (n = 124), and employees (n = 91). MEASUR...
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abstract：OBJECTIVES:To determine the frequency of aspiration pneumonitis in nursing home residents with an initial diagnosis of pneumonia and to compare the clinical characteristics, management, and outcome of aspiration pneumonitis with those of pneumonia. DESIGN:Retrospective chart review. SETTING:Hospital geriatric unit fo...
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journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
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更新日期：1977-04-01 00:00:00
abstract：OBJECTIVES:To determine how poor sleep affects the health of older ethnic minorities. DESIGN:Cross-sectional study involving a population-based survey. SETTING:Hispanic Established Population for the Epidemiologic Study of the Elderly (H-EPESE) survey conducted in the southwestern United States. PARTICIPANTS:Two tho...
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更新日期：2012-10-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2012-10-01 00:00:00
abstract：:The US Department of Health and Human Services and the Foundation for the National Institutes of Health, through private sector support, sponsored the National Research Summit on Dementia Care: Building Evidence for Services and Supports (Summit) in 2017. Various workgroups were asked to address topics of interest in ...
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更新日期：2020-03-01 00:00:00
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更新日期：2016-08-01 00:00:00
abstract：:The effect of do-not-resuscitate (DNR) orders on physicians' decisions to provide life-prolonging treatments other than cardiopulmonary resuscitation (CPR) for patients near the end of life was explored using a cross-sectional mailed survey. Each survey presented three patient scenarios followed by 10 treatment decisi...
journal_title：Journal of the American Geriatrics Society
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1532-5415.2002.50620.x
更新日期：2002-12-01 00:00:00
