Treatment of vasculogenic sexual dysfunction with pentoxifylline.

Abstract:

OBJECTIVE:To evaluate the use of pentoxifylline to treat impotence in men with mild to moderate penile vascular insufficiency. DESIGN:Double-blind randomized clinical trial. SETTING:Sexual Dysfunction Clinic at VA Medical Center, Sepulveda, CA. PARTICIPANTS:Convenience sample of couples. INTERVENTION:Twelve weeks of treatment with placebo or 400 mg tid of pentoxifylline. MEASUREMENTS:(1) Report of patient verified by partner as to number of coital episodes per month; (2) penile-brachial pressure index determinations. RESULTS:Pentoxifylline therapy regularly increased the PBPI in impotent men in comparison with the placebo, frequently into the normal range. Pentoxifylline therapy was particularly useful in restoring the PBPI in men with the pelvic steal syndrome; six of seven such subjects improved into the normal range. During the pentoxifylline treatment period, in contrast with the control period, nine men were able to reestablish coital function and three had no improvement. Six couples did not attempt intercourse despite a professed interest in sexual activity; however five out of the six men experienced erections during episodes of fantasy or attempts at masturbation during treatment. There were no complications of therapy. CONCLUSIONS:These promising preliminary results suggest a well tolerated alternative therapy for erectile dysfunction in patients with mild to moderate penile vascular disease.

journal_name

J Am Geriatr Soc

authors

Korenman SG,Viosca SP

doi

10.1111/j.1532-5415.1993.tb06941.x

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

363-6

issue

4

eissn

0002-8614

issn

1532-5415

journal_volume

41

pub_type

临床试验,杂志文章,随机对照试验
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    更新日期:2005-08-01 00:00:00

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    更新日期:2002-05-01 00:00:00

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    pub_type: 杂志文章

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    doi:10.1111/jgs.16219

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    更新日期:1992-08-01 00:00:00

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    journal_title:Journal of the American Geriatrics Society

    pub_type: 临床试验,杂志文章,随机对照试验

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    journal_title:Journal of the American Geriatrics Society

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    更新日期:1989-04-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1991.tb03569.x

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    更新日期:1991-12-01 00:00:00

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    journal_title:Journal of the American Geriatrics Society

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1532-5415.1999.tb07237.x

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    更新日期:1999-04-01 00:00:00

  • Cross-cultural cognitive examination: validation of a dementia screening instrument for neuroepidemiological research.

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    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1993.tb06758.x

    authors: Glosser G,Wolfe N,Albert ML,Lavine L,Steele JC,Calne DB,Schoenberg BS

    更新日期:1993-09-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2009.02490.x

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2004.52068.x

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    pub_type: 临床试验,杂志文章,随机对照试验

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