Clinical phenotype of families with longevity.

Abstract:

OBJECTIVES:To determine whether offspring of centenarians acquired protection from age-related diseases. DESIGN:Case-control study. SETTING:The study was part of the Longevity Genes Project at Albert Einstein College of Medicine. PARTICIPANTS:Centenarians (n=145), offspring of centenarians (n=180), and spouses of the offspring of centenarians (n=75) as a control group. Two additional groups served as controls: age-matched Ashkenazi Jews, and an age-matched control group from the Third National Health and Nutrition Examination Survey. MEASUREMENTS:Self-reported family history of longevity; prevalence of hypertension, diabetes mellitus, heart attacks, and strokes; and objective measurements of body mass index and fat mass. RESULTS:Parents of centenarians (born in approximately 1870) had a markedly greater ( approximately sevenfold) "risk" for longevity (reaching ages 90-99), supporting the notion that genetics contributed to longevity in these families. The offspring of long-lived parents had significantly lower prevalence of hypertension (by 23%), diabetes mellitus (by 50%), heart attacks (by 60%), and strokes (no events reported) than several age-matched control groups. CONCLUSION:Offspring of centenarians may inherit significantly better health. The authors suggest that a cohort of these subjects and their spouses is ideal to study the phenotype and genotype of longevity and its interaction with the environment.

journal_name

J Am Geriatr Soc

authors

Atzmon G,Schechter C,Greiner W,Davidson D,Rennert G,Barzilai N

doi

10.1111/j.1532-5415.2004.52068.x

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

274-7

issue

2

eissn

0002-8614

issn

1532-5415

pii

52068

journal_volume

52

pub_type

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