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Serologic profiles as immunologic markers for different clinical presentations of lupus erythematosus.

Abstract：

:The clinical and laboratory features of 55 patients with lupus erythematosus (LE), grouped on the basis of six nuclear immunofluorescent pattern results commonly encountered in this disease were examined. Serologic profiles of antinuclear antibodies (ANA), anti-DNA and anti-ENA results can serve as immunologic markers in LE for a benign subset and two other groups with a different incidence of certain clinical characteristics. The large speckle-like thready pattern without antibodies to DNA or ENA is an immunologic marker for a benign LE subset, with generalized skin lesions with or without joint involvement only. Significant levels of the anti-DNA antibodies with the shrunken peripheral, peripheral, or leukocyte-specific ANA with a particulate pattern are markers for severe systemic involvement. The thready pattern with antibodies to ENA (Sm antigen) and leukocyte-specific ANA without a particulate pattern, with or without antibodies to DNA or ENA, indicate less severe systemic disease.

journal_name

Semin Arthritis Rheum

journal_title

Seminars in arthritis and rheumatism

authors

Pelachyk JM,Heinzerling R,Burnham TK

doi

10.1016/0049-0172(83)90018-5

subject

Has Abstract

pub_date

1983-05-01 00:00:00

pages

382-9

issue

4

eissn

0049-0172

issn

1532-866X

pii

0049-0172(83)90018-5

journal_volume

12

pub_type

杂志文章

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