Abstract:
BACKGROUND:Whilst weight loss results in many beneficial metabolic consequences, the immediate improvement in glycaemia after Roux-en-Y Gastric bypass (RYGB) remains intriguing. Duodenal jejunal bypass (DJB) induces similar glycaemic effects, while not affecting calorie intake or weight loss. We studied diabetic ZDF(fa/fa) rats to compare the effects of DJB and RYGB operations on glycaemia. METHODS:Male ZDF(fa/fa) rats, aged 12 weeks underwent RYGB, DJB or sham operations. Unoperated ZDF(fa/fa) and ZDF(fa/+w)ere used as controls. Body weight, food intake, fasting glucose, insulin and gut hormones were measured at baseline and on postoperative days 2, 10 and 35. An oral glucose tolerance test (OGTT) was performed on days 12 and 26. RESULTS:DJB had similar food intake and body weight to sham-operated and unoperated control ZDF(fa/fa) rats (p = NS), but had lower fasting glucose (p < 0.05). RYGB had lower food intake, body weight and fasting glucose compared to all groups (p < 0.001). DJB prevented the progressive decline in fasting insulin observed in the sham-operated or unoperated ZDF(fa/fa) rats, while RYGB with normalized glycaemia reduced the physiological requirement for raised fasting insulin. CONCLUSIONS:Bypassing the proximal small bowel with the DJB has mild to moderate body weight independent effects on glucose homeostasis and preservation of fasting insulin levels in the medium term. These effects might be further amplified by the additional anatomical and physiological changes after RYGB.
journal_name
Obes Surgjournal_title
Obesity surgeryauthors
Seyfried F,Bueter M,Spliethoff K,Miras AD,Abegg K,Lutz TA,le Roux CWdoi
10.1007/s11695-014-1301-3subject
Has Abstractpub_date
2014-11-01 00:00:00pages
1888-95issue
11eissn
0960-8923issn
1708-0428journal_volume
24pub_type
杂志文章相关文献
OBESITY SURGERY文献大全abstract:BACKGROUND:Fibromyalgia is a chronic debilitating disorder affecting 3-5% of the US population. Treatment of this disorder is a challenge. The incidental finding of improvement of fibromyalgia following laparoscopic Roux-en-Y gastric bypass stimulated us to study this phenomenon. METHODS:A retrospective chart review o...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-008-9505-z
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:The objective of the present study was to investigate vitamin A nutritional status in individuals with class III obesity through a biochemical indicator (retinol and beta-carotene serum levels), correlating these findings with non-alcoholic fatty liver disease (NAFLD) presence and its risk factors. METHODS:...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-007-9361-2
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:Among bariatric operations, laparoscopic adjustable gastric banding (LAGB) has been the preferred one in Europe and Australia, and has become recently popular in the USA. Like every surgical procedure, however, it is not devoid of specific complications, like slippage, band erosion, outlet obstruction and po...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089206778392329
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Gastroesophageal reflux disease (GERD) is probably the main drawback of laparoscopic sleeve gastrectomy (LSG). Herein, we critically discuss the issue and report the results of the first international consensus conference held in Montpellier, France, during June 2019. METHODS:Fifty international bariatric e...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-020-04749-0
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:The authors attempted to determine if mental status could predict personality profiles, 18 months after surgery in morbidly obese patients. METHODS:Personality characteristics of 100 morbidly obese patients (85 female, 15 male) were analyzed after bariatric surgery (vertical banded gastroplasty). Patients w...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089203765887723
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:Laparoscopic sleeve gastrectomy (LSG) is the most preferred technique in morbidly obese patients for weight loss. There is a controversy about the routine preoperative evaluation of the stomach and the routine microscopic examination of all LSG specimens. Our aim is to analyze the results of both preoperativ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-017-3014-x
更新日期:2018-05-01 00:00:00
abstract:INTRODUCTION:Obesity in young people is one of the most serious public health problems worldwide. Moreover, the mechanisms preventing obese adolescents from losing and maintaining weight loss have been elusive. Laparoscopic sleeve gastrectomy (LSG) is successful at achieving long-term weight loss in patients across all...
journal_title:Obesity surgery
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11695-017-2999-5
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Bariatric surgery constitutes the most effective treatment for severely obese type 2 diabetic patients. Exenatide is a glucagon-like peptide 1 receptor agonist that can improve glycemic control and cause weight loss in patients with type 2 diabetes. Clinical experience with exenatide in obese patients with t...
journal_title:Obesity surgery
pub_type: 临床试验,杂志文章
doi:10.1007/s11695-014-1563-9
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:A technique for standard laparoscopic BPD was developed. METHODS:Standard laparoscopic BPD was performed in 26 morbidly obese patients with mean BMI 43. Details of the technique, using 6 trocars, and instrumentation are described. Intestinal limb lengths were measured fully stretched, and the gastric remnan...
journal_title:Obesity surgery
pub_type: 杂志文章,评审
doi:10.1381/096089202762552692
更新日期:2002-04-01 00:00:00
abstract::Lithium is one of the major treatment options in bipolar disorder. Bariatric surgery can significantly modify the oral bioavailability of drugs, and lithium is no exception; although in most cases drug absorption seems to decrease, in the case of lithium, toxicity is the risk. In this article, we describe a 61-year-ol...
journal_title:Obesity surgery
pub_type: 杂志文章,评审
doi:10.1007/s11695-018-3597-x
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Early or late pouch dilatations account for a moderate complication rate after restrictive bariatric operations. Various strategies were developed to prevent or treat pouch dilatations. METHODS:A case of necrosis of gastric wall in a concentric dilated pouch following laparoscopic adjustable gastric banding...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/09608920160558768
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Obesity impairs quality of life, but the perception of the impairment could be different from one country to another. The purpose was to compare weight-related quality of life (QOL) between cohorts from Spain and North America. METHODS:A cross-sectional case-control study was performed between two populatio...
journal_title:Obesity surgery
pub_type: 杂志文章,多中心研究
doi:10.1007/s11695-012-0791-0
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:There is no consensus on the ideal gastrojejunostomy anastomosis (GJA) technique in laparoscopic Roux-en-Y gastric bypass (LRYGB). We reviewed our experience with three GJA techniques (hand-sewn (HSA), linear-stapled (LSA), and 25-mm circular-stapled (CSA)) to determine which anastomosis technique is associa...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-011-0470-6
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Fluorescence cholangiography represents an incisionless technique that can be applied during laparoscopic cholecystectomy to visualize bile ducts. Our objective was to evaluate and detect variances of fluorescence imaging in obese and non-obese patients. METHODS:Prospective patients were selected for laparo...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-015-1781-9
更新日期:2016-03-01 00:00:00
abstract::Duodenal mucosal resurfacing (DMR) is an innovative endoscopic bariatric and metabolic therapy (EBMT) emerging in recent years. It uses the duodenum to achieve better glycemic and weight control. This study aimed to evaluate in a critical and systematic way the metabolic effects of this procedure. Electronic searches ...
journal_title:Obesity surgery
pub_type: 杂志文章,评审
doi:10.1007/s11695-020-05170-3
更新日期:2021-01-08 00:00:00
abstract:BACKGROUND:Endoscopic stents are successful in the management of surgical leaks; however, stent migration remains a significant problem. In this study, we present our approach depending on a large bariatrics-specific stent (Mega stent) and over-the-scope clips in the management of post-bariatric surgery leaks. METHODS...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-017-2808-1
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Few previous studies have assessed the safety of bariatric surgery in septuagenarians. METHODS:A retrospective analysis of all patients 70 years or older who underwent laparoscopic sleeve gastrectomy at our institution between 2012 and 2017 was performed. This group was compared to a matched cohort of young...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-018-3418-2
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to establish the efficacy of a new surgical technique for the placement of the silicone gastric band (LAP-Band) in the presence of a large (>5 cm) hiatus hernia. METHOD:Hiatus hernias >5 cm were identified by endoscopy and barium meal in 6 patients. Each patient underwent hiata...
journal_title:Obesity surgery
pub_type: 临床试验,杂志文章
doi:10.1381/096089299765553511
更新日期:1999-04-01 00:00:00
abstract:BACKGROUND:Despite recognition of the importance of laparoscopic adjustable gastric banding (LAGB) aftercare for optimal surgical outcomes and the failure of some patients to attend regularly, factors influencing LAGB aftercare attrition have not been thoroughly examined in the literature. METHODS:Patients' perspectiv...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-013-1086-9
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:The duodenal-jejunal bypass liner (DJBL) represents a novel endoscopic minimally invasive treatment option for obesity-associated type 2 diabetes (T2D), affecting body weight and metabolic control. Until now, the effects of DJBL on cardiovascular risk have never been investigated. METHODS:Between 2012 and 2...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-019-04324-2
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Long-term outcomes of gastric banding regarding depression and predictors of change in depression are still unclear. This prospective, controlled study investigated depression and self-acceptance in morbidly obese patients before and after gastric banding. METHODS:A total of 248 morbidly obese patients (mea...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-007-9316-7
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Morbidly obese patients, despite normal laboratory tests and no clinical evidence of liver disease, present a high prevalence of hepatic histological changes. Liver biopsy is able to provide the diagnosis, staging and assessment of follow-up of hepatic disease, thus helping to define clinical management. The...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089206775565159
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine whether the anatomicofunctional changes induced by vertical gastroplasty lead to pH alterations in the esophagus and body and antrum of the stomach. MATERIALS AND METHODS:23 non-smoking volunteers (3 men, 20 women) mean age 35.29 +/- SD 6.85 years, mean weight 163.17 +...
journal_title:Obesity surgery
pub_type: 临床试验,杂志文章
doi:10.1381/096089204322857690
更新日期:2004-02-01 00:00:00
abstract::The sleeve gastrectomy (SG) is the most popular weight loss procedure in the USA. Despite its popularity, little is definitively known about the variables that correlate with weight loss. We performed a literature search to find studies that reported variables that correlated with weight loss following SG. Forty-eight...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-018-03666-7
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Venous thromboembolic (VTE) disease is a much-feared complication of bariatric surgery. The most common unexpected cause of death in the morbidly obese patient is pulmonary embolism (PE). Recent data supports the expanded use of systemic thrombolytics in hemodynamically stable patients with PE and echocardio...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089203322509426
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:For many years, the Roux-en-Y Gastric Bypass (RYGB) was considered a good balance of complications and weight loss. According to several short-term studies, single anastomosis duodenal switch or stomach intestinal pylorus sparing surgery (SIPS) offers similar weight loss to RYGB with fewer complications and ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-018-3309-6
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Abnormal glucose profiles have been described after Roux-en-Y gastric bypass (RYGB) with intense postprandial hyperglycemic peaks in some but not all the patients. The underlying mechanisms of these anomalies are not totally understood. OBJECTIVE:The aim of this study is to determine whether or not the comp...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-015-1930-1
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Severely obese type 2 diabetics who undergo Roux-en Y gastric bypass surgery have significant improvements in glycaemic control. Little work has been undertaken to establish the independent predictors of such resolution or to develop a predictive model. The aim of this study was to develop a mathematical mod...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-011-0370-9
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Laparoscopic gastric bypass (LGBP) is being performed widely as a treatment of choice for morbid obesity. Advantages over open gastric bypass (OGBP) have not been well documented in controlled studies. The aim of this study is to evaluate the early postoperative outcomes after LGBP and OGBP using a matched p...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089203765887624
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:A clinical pathway for gastric bypass surgery (GBS) implemented at our institution in 1999 resulted in reduced costs and decreased variability in patient care. However, a reanalysis of GBS hospital costs identified a 16% incidence of "cost outliers". We hypothesized that analysis of clinical variables would ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089203321136557
更新日期:2003-02-01 00:00:00