A model for predicting the resolution of type 2 diabetes in severely obese subjects following Roux-en Y gastric bypass surgery.


BACKGROUND:Severely obese type 2 diabetics who undergo Roux-en Y gastric bypass surgery have significant improvements in glycaemic control. Little work has been undertaken to establish the independent predictors of such resolution or to develop a predictive model. The aim of this study was to develop a mathematical model and establish independent predictors for the resolution of diabetes. METHODS:A consecutive sample of 130 severely obese type 2 diabetics who underwent gastric bypass surgery for weight loss from November 1997 to May 2007 with prospective pre-operative documentation of biochemical and clinical measurements was followed up over 12 months. Logistic discrimination analysis was undertaken to identify those variables with independent predictive value and to develop a predictive model for resolution of type 2 diabetes. Consecutive samples of 130 patients with body mass index (BMI) ≥ 35 with type 2 diabetes were selected. One hundred and twenty-seven patients completed the study with a sufficient data set. Patients were deemed unresolved if (1) diabetic medication was still required after surgery; (2) if fasting plasma glucose (FPG) remained >7 mmol/L; or (3) HbA1c remained >7%. RESULTS:Resolution of diabetes was seen in 84%, while diabetes remained but was improved in 16% of patients. Resolution was rapid and sustained with 74% of those on medication before surgery being able to discontinue this by the time of discharge 6 days following surgery. Five pre-operative variables were found to have independent predictive value for resolution of diabetes, including BMI, HbA1c, FPG, hypertension and requirement for insulin. Two models have been proposed for prediction of diabetes resolution, each with 86% correct classification in this cohort of patients. CONCLUSIONS:Type 2 diabetes resolves in a very high percentage of patients undergoing gastric bypass surgery for severe obesity. The key predictive variables include pre-operative BMI, HbA1c, FPG, the presence of hypertension and diabetic status.


Obes Surg


Obesity surgery


Hayes MT,Hunt LA,Foo J,Tychinskaya Y,Stubbs RS




Has Abstract


2011-07-01 00:00:00












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    abstract:BACKGROUND:Intragastric band migration is an unusual but major long-term complication of gastric banding: its frequency ranges from 0.5-3.8% and always requires removal of the band. Different laparoscopic, laparotomic or endoscopic methods are currently used for band removal. METHODS:571 morbidly obese patients underw...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Lattuada E,Zappa MA,Mozzi E,Fichera G,Granelli P,De Ruberto F,Antonini I,Radaelli S,Roviaro G

    更新日期:2007-03-01 00:00:00

  • Chronic increase of bone turnover markers after biliopancreatic diversion is related to secondary hyperparathyroidism and weight loss. Relation with bone mineral density.

    abstract:BACKGROUND:Biliopancreatic diversion (BPD) is the most effective bariatric procedure. Around 70% of these patients have secondary hyperparathyroidism (SH) in the long term as a consequence of calcium and vitamin D malabsorption. This work was aimed to study the influence of SH on bone turnover and its relationship with...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Balsa JA,Botella-Carretero JI,Peromingo R,Caballero C,Muñoz-Malo T,Villafruela JJ,Arrieta F,Zamarrón I,Vázquez C

    更新日期:2010-04-01 00:00:00

  • Two-day length of stay following open Roux-En-Y gastric bypass: is it feasible, safe and reasonable?

    abstract:BACKGROUND:As our bariatric program matured, we noted that length of stay (LOS) steadily decreased. This led us to analyze our experience to identify factors contributing to this abbreviated LOS and to evaluate the safety of discharging patients with only a 2-day LOS. METHODS:All patients undergoing open Roux-en-Y gas...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Stellato TA,Hallowell PT,Crouse C,Schuster M,Petrozzi MC

    更新日期:2004-01-01 00:00:00

  • Efficacy of the SF-36 questionnaire in identifying obese patients with psychological discomfort.

    abstract:BACKGROUND:The primary endpoint of this study was to assess the association of health-related quality of life (QoL) and the presence of psychopathology. The association of other patients' characteristics and of Cognitive Behavioral Assessment (CBA) scales with quality of life (QoL) was also evaluated. METHODS:100 cons...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Callegari A,Michelini I,Sguazzin C,Catona A,Klersy C

    更新日期:2005-02-01 00:00:00

  • The LM Proring Band and left approach in laparoscopic vertical banded gastroplasty: preliminary results in 44 cases.

    abstract:BACKGROUND:Morbid obesity is one of the most important social and medical issues in Western countries. Many authors have adopted a minimally invasive approach to reproduce current bariatric operations. The aim of this study is to present a personal technique for laparoscopic vertical banded gastroplasty (LVBG) and the ...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Lointier PH,Verdier PH,Verdier A

    更新日期:2002-10-01 00:00:00

  • Laparoscopic hand-sewn revisional gastrojejunal plication for weight loss failure after Roux-en-Y gastric bypass.

    abstract:BACKGROUND:Revisional surgery has become a widely accepted alternative for weight loss failure/regain after bariatric surgery. However, it is associated to higher morbi-mortality and lesser weight loss than primary bariatric procedure. Our aims are to present a novel technique for weight loss treatment after failed lap...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: León F,Maiz C,Daroch D,Quezada N,Gabrielli M,Muñoz C,Boza C

    更新日期:2015-04-01 00:00:00

  • Does the Size of the Upper Pouch Affect Weight Loss after Vertical Banded Gastroplasty.

    abstract::BACKGROUND: The importance of creating a small 10-20 ml upper pouch when performing a vertical banded gastroplasty (VBG) is often stated in the literature. In order to test the hypothesis that weight loss is superior in patients with a small upper pouch, we examined the weight loss curves for three different pouch siz...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Näslund E,Backman L,Granström L,Stockeld D

    更新日期:1995-11-01 00:00:00

  • Outcomes of Sleeve Gastrectomy in Septuagenarians.

    abstract:BACKGROUND:Few previous studies have assessed the safety of bariatric surgery in septuagenarians. METHODS:A retrospective analysis of all patients 70 years or older who underwent laparoscopic sleeve gastrectomy at our institution between 2012 and 2017 was performed. This group was compared to a matched cohort of young...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Al-Kurd A,Grinbaum R,Mordechay-Heyn T,Asli S,Abubeih A,Mizrahi I,Mazeh H,Beglaibter N

    更新日期:2018-12-01 00:00:00

  • Bariatric Nutrition Guidelines for the Indian Population.

    abstract:BACKGROUND:Bariatric surgery numbers have seen a sharp rise in India in the last decade. A country known for its undernourished population has seen economic growth and with it, greater influence of western culture and foods. The obesity epidemic is on the rise here and India is one of the 10 most obese nations of the w...

    journal_title:Obesity surgery

    pub_type: 共识发展会议,杂志文章


    authors: Remedios C,Bhasker AG,Dhulla N,Dhar S,Lakdawala M

    更新日期:2016-05-01 00:00:00

  • Role of preoperative imaging with multidetector computed tomography in the management of patients with gastroesophageal reflux disease symptoms after laparoscopic sleeve gastrectomy.

    abstract:BACKGROUND:The aims of the study were to evaluate if multidetector computed tomography (MDCT) can be helpful and useful in the decision-making process in sleeve patients with gastroesophageal reflux disease (GERD) symptoms and to demonstrate the reproducibility and accuracy of the technique. METHODS:Twenty-three patie...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Rengo M,Bellini D,Iorio O,De Cecco CN,Rizzello M,Cavallaro G,Carabotti M,Laghi A,Silecchia G

    更新日期:2013-12-01 00:00:00

  • Effects of Biliopancreatic Diversion on Bone Turnover Markers and Association with Hormonal Factors in Patients with Severe Obesity.

    abstract:BACKGROUND:This study evaluated early and medium-term changes in bone turnover markers, and their associations with weight loss, total bone mineral density (BMD), and hormonal changes after biliopancreatic diversion (BPD). METHODS:Ancillary study from a one-year prospective cohort of 16 individuals assessed before, 3 ...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Turcotte AF,Grenier-Larouche T,Ung RV,Simonyan D,Carreau AM,Carpentier AC,Mac-Way F,Michou L,Tchernof A,Biertho L,Lebel S,Marceau S,Gagnon C

    更新日期:2019-03-01 00:00:00

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    abstract:BACKGROUND:Some patients who underwent vertical banded gastroplasty (VBG) need revisional operations because of poor weight loss and remaining comorbidities. The duodenal switch (DS) procedure with partial gastrectomy is known as an effective method for treatment of severe obesity and related dyslipoproteinemias and di...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Yashkov YI,Oppel TA,Shishlo LA,Vinnitsky LI

    更新日期:2001-10-01 00:00:00

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    abstract:BACKGROUND:Management of the leak is determined by the duration of the leak from the initial surgery. Acute leaks occurring less than 72 hours after surgery are best managed with reoperation and primary repair. Intermediate leaks, greater than 72 hours but less than 12 weeks, can be managed with non-operative managemen...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Dugan N,Nimeri A

    更新日期:2020-09-01 00:00:00

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    abstract:AIM:This study aims to evaluate the role of simple carbohydrates and alcohol intake in determining weight of stabilization at long-term following malabsorptive bariatric surgery. MATERIAL AND METHODS:Sixty patients at more than 2 years following biliopancreatic diversion (BPD) were submitted to an alimentary interview...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Cornicelli M,Noli G,Marinari GM,Adami GF

    更新日期:2010-09-01 00:00:00

  • Long-Term Evaluation of Biliary Reflux on Esogastric Mucosae after One-Anastomosis Gastric Bypass and Esojejunostomy in Rats.

    abstract:BACKGROUND:One-anastomosis gastric bypass/mini-gastric bypass (OAGB/MGB) remains controversial because it may cause chronic biliary reflux (BR). The risk of developing esogastric cancer due to BR after OAGB/MGB is based on the results of experimental rat studies using esojejunostomy (EJ). The aim of this study was to a...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: M'Harzi L,Chevallier JM,Certain A,Autret G,Levenson G,Louis D,Poghosyan T,Berger A,Rahmi G,Broudin C,Clément O,Douard R,Tavitian B,Bruzzi M

    更新日期:2020-07-01 00:00:00

  • Calculating surgical costs: how accurate and predictable is the cost of a laparoscopic Roux-en-Y gastric bypass?

    abstract:BACKGROUND:Although bariatric surgery is highly effective for controlling obesity and its complications, it is uncovered by third-party payers in many countries. High cost and unpredictable expenses account for the lack of coverage. We developed at our obesity clinic a fixed package for the Laparoscopic Roux-en-Y Gastr...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Mosti M,Domínguez G,Herrera MF

    更新日期:2007-12-01 00:00:00

  • YKL-40 is elevated in morbidly obese patients and declines after weight loss.

    abstract:BACKGROUND:Patients suffering from morbid obesity (MO) have an increased cardiovascular morbidity and mortality. This increased cardiovascular burden is believed to be caused by a sub-inflammatory state through an increased secretion of monocyte chemoattractant protein-1 (MCP-1) by the adipose tissue, resulting in insu...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Hempen M,Kopp HP,Elhenicky M,Höbaus C,Brix JM,Koppensteiner R,Schernthaner G,Schernthaner GH

    更新日期:2009-11-01 00:00:00

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    abstract::Considerable controversy exists about the perioperative management of patients at high risk for obstructive sleep apnea (OSA) in free-standing clinics. Eighty-eight percent of an American Society of Anesthesiologists expert panel felt that upper abdominal laparoscopic surgery could not be performed safely on an outpat...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Kurrek MM,Cobourn C,Wojtasik Z,Kiss A,Dain SL

    更新日期:2011-10-01 00:00:00

  • Subcostal Transversus Abdominis Plane Block for Laparoscopic Sleeve Gastrectomy, Is It Worth the Time?

    abstract:BACKGROUND:Obesity is a complex and multifactorial disease whose incidence has increased, making it a serious public health issue. Laparoscopic sleeve gastrectomy (LSG) is one of the most common surgical procedures that is chosen for bariatric surgery. Decreasing postoperative pain in these patients which will increase...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Coşkun M,Yardimci S,Arslantaş MK,Altun GT,Uprak TK,Kara YB,Cingi A

    更新日期:2019-10-01 00:00:00

  • Lithium Toxicity with Severe Bradycardia Post Sleeve Gastrectomy: a Case Report and Review of the Literature.

    abstract::Lithium is one of the major treatment options in bipolar disorder. Bariatric surgery can significantly modify the oral bioavailability of drugs, and lithium is no exception; although in most cases drug absorption seems to decrease, in the case of lithium, toxicity is the risk. In this article, we describe a 61-year-ol...

    journal_title:Obesity surgery

    pub_type: 杂志文章,评审


    authors: Dahan A,Porat D,Azran C,Mualem Y,Sakran N,Abu-Abeid S

    更新日期:2019-02-01 00:00:00

  • Usefulness of Upper Gastrointestinal Symptoms as a Driver to Prescribe Gastroscopy in Obese Patients Candidate to Bariatric Surgery. A Prospective Study.

    abstract:BACKGROUND:Before bariatric surgery, the necessity of routine upper gastrointestinal endoscopy is controversial, and guidelines recommend endoscopy in symptomatic cases. However, impaired visceral sensation occurring in obese patients may be misleading. The purpose of the study is to evaluate prospectively the prevalen...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Carabotti M,Avallone M,Cereatti F,Paganini A,Greco F,Scirocco A,Severi C,Silecchia G

    更新日期:2016-05-01 00:00:00

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    abstract::A triple-lumen Moss(c) gastrostomy tube was advanced into the proximal duodenum as an adjunct to the postoperative management of patients who underwent vertical banded gastroplasty (VBG) for the treatment of morbid obesity. The tube efficiently aspirated the proximal duodenum and stomach to prevent postoperative ileus...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Nassif AC

    更新日期:1991-03-01 00:00:00

  • The impact of various anthropometric measurements of obesity on pulmonary function in candidates for surgery.

    abstract:BACKGROUND:Obesity has proven to be associated with respiratory symptoms and impaired pulmonary function, which could increase the incidence of postoperative complications after bariatric surgery. However, the component of obesity that has the most influence on pulmonary function has not been identified, especially in ...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Wei YF,Wu HD,Chang CY,Huang CK,Tai CM,Hung CM,Tseng WK,Wu CC

    更新日期:2010-05-01 00:00:00

  • Weight changes in spouses of gastric bypass patients.

    abstract:BACKGROUND:The effectiveness of gastric bypass for weight loss has been demonstrated. No study has documented the effect of this surgery on patient spouses' weight. Excess leftover food may be consumed by the spouses of gastric bypass patients, which may increase the total caloric intake compared to the preoperative in...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Madan AK,Turman KA,Tichansky DS

    更新日期:2005-02-01 00:00:00

  • Laparoscopic sleeve gastrectomy: surgical technique, indications and clinical results.

    abstract:BACKGROUND:Laparoscopic sleeve gastrectomy (LSG) has been introduced as a multipurpose restrictive procedure for obese patients. Variations of the surgical technique may be important for the late results. METHODS:50 patients submitted to LSG from January 2005 to December 2006 were studied. Mean age was 38.2 years, pre...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Braghetto I,Korn O,Valladares H,Gutiérrez L,Csendes A,Debandi A,Castillo J,Rodríguez A,Burgos AM,Brunet L

    更新日期:2007-11-01 00:00:00

  • Reasons and outcomes of reoperative bariatric surgery for failed and complicated procedures (excluding adjustable gastric banding).

    abstract:BACKGROUND:The rise of bariatric surgery has lead to an increasing number of reoperations for failed bariatric procedures. The reasons and types of these operations are varied in nature and remain to be defined. METHODS:A retrospective review of a prospectively collected database was conducted to identify patients who...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Patel S,Szomstein S,Rosenthal RJ

    更新日期:2011-08-01 00:00:00

  • Resolution of Female Sexual Dysfunction (FSD) Among the Obese Multiethnic Malaysian Women Now a Reality with Bariatric Surgery: a Prospective Pilot Study in Malaysia.

    abstract:INTRODUCTION:Female sexual dysfunction (FSD) among the obese women is often under diagnosed and ignored especially in Malaysia, a nation of conservative multiethnic society. There are only a few studies on FSD resolution post-bariatric surgery. The objective was to identify the rate and resolution or improvement of FSD...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Lechmiannandan S,Panirselvam M,Muninathan P,Hussin N,Rajan R,Sidi H,Kosai NR,Vinayak CR

    更新日期:2019-05-01 00:00:00

  • Weight reduction after an early version of the open gastric bypass for morbid obesity: results after 23 years.

    abstract:BACKGROUND:While numerous promising short-term results of open gastric bypass for morbid obesity were published, the long-term outcome of earlier versions was somewhat disappointing. Thus, it was not until 1993 that this procedure was reintroduced with current modifications and now performed laparoscopically. Published...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Günther K,Vollmuth J,Weissbach R,Hohenberger W,Husemann B,Horbach T

    更新日期:2006-03-01 00:00:00

  • High Rates of Nicotine Use Relapse and Ulcer Development Following Roux-en-Y Gastric Bypass.

    abstract:PURPOSE:Given that smoking is known to contribute to gastrojejunal anastomotic (GJA) ulcers, cessation is recommended prior to laparoscopic Roux-en-Y gastric bypass (LRYGB). However, smoking relapse rates and the exact ulcer risk remain unknown. This study aimed to define smoking relapse, risk of GJA ulceration, and co...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Athanasiadis DI,Christodoulides A,Monfared S,Hilgendorf W,Embry M,Stefanidis D

    更新日期:2020-09-22 00:00:00

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    abstract::Incidental gastric and small bowel lesions are commonly encountered during bariatric surgery. Resection of these lesions with negative margins in the same sitting is curative; however, this may necessitate intraoperative change of plan. We present a 44-year-old super obese lady in whom an exophytic jejunal mass was fo...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Kumar A,Baksi A,Yadavalli SD,Aggarwal S

    更新日期:2021-01-19 00:00:00