A model for predicting the resolution of type 2 diabetes in severely obese subjects following Roux-en Y gastric bypass surgery.


BACKGROUND:Severely obese type 2 diabetics who undergo Roux-en Y gastric bypass surgery have significant improvements in glycaemic control. Little work has been undertaken to establish the independent predictors of such resolution or to develop a predictive model. The aim of this study was to develop a mathematical model and establish independent predictors for the resolution of diabetes. METHODS:A consecutive sample of 130 severely obese type 2 diabetics who underwent gastric bypass surgery for weight loss from November 1997 to May 2007 with prospective pre-operative documentation of biochemical and clinical measurements was followed up over 12 months. Logistic discrimination analysis was undertaken to identify those variables with independent predictive value and to develop a predictive model for resolution of type 2 diabetes. Consecutive samples of 130 patients with body mass index (BMI) ≥ 35 with type 2 diabetes were selected. One hundred and twenty-seven patients completed the study with a sufficient data set. Patients were deemed unresolved if (1) diabetic medication was still required after surgery; (2) if fasting plasma glucose (FPG) remained >7 mmol/L; or (3) HbA1c remained >7%. RESULTS:Resolution of diabetes was seen in 84%, while diabetes remained but was improved in 16% of patients. Resolution was rapid and sustained with 74% of those on medication before surgery being able to discontinue this by the time of discharge 6 days following surgery. Five pre-operative variables were found to have independent predictive value for resolution of diabetes, including BMI, HbA1c, FPG, hypertension and requirement for insulin. Two models have been proposed for prediction of diabetes resolution, each with 86% correct classification in this cohort of patients. CONCLUSIONS:Type 2 diabetes resolves in a very high percentage of patients undergoing gastric bypass surgery for severe obesity. The key predictive variables include pre-operative BMI, HbA1c, FPG, the presence of hypertension and diabetic status.


Obes Surg


Obesity surgery


Hayes MT,Hunt LA,Foo J,Tychinskaya Y,Stubbs RS




Has Abstract


2011-07-01 00:00:00












  • A Nationwide Safety Analysis of Discharge on the First Postoperative Day After Bariatric Surgery in Selected Patients.

    abstract:BACKGROUND:Enhanced recovery after surgery has led to early recovery and shorter hospital stay after laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG). This study aims to assess feasibility and outcomes of postoperative day (POD) 1 discharge after LRYGB and LSG from the Metabolic a...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Ardila-Gatas J,Sharma G,Lloyd SJ,Khorgami Z,Tu C,Schauer PR,Brethauer SA,Aminian A

    更新日期:2019-01-01 00:00:00

  • Preoperative and Postoperative Assessments of Biochemical Parameters in Patients with Severe Obesity Undergoing Laparoscopic Sleeve Gastrectomy.

    abstract:BACKGROUND:The study aim was to determine the prevalence of abnormal serum biochemistries associated with micronutrient deficiencies before and after laparoscopic sleeve gastrectomy (LSG). METHODS:Two hundred and one patients had LSG surgery between May 2011 and May 2014. Using a prospective cohort study design, data ...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Gregory DM,Twells LK,Lester KK,Midodzi WK,Pedersen MR,Pace D,Smith C,Boone D,Randell EW,Kovacs CS

    更新日期:2018-08-01 00:00:00

  • Band erosion following gastric banding: how to treat it.

    abstract:BACKGROUND:Intragastric band migration is an unusual but major long-term complication of gastric banding: its frequency ranges from 0.5-3.8% and always requires removal of the band. Different laparoscopic, laparotomic or endoscopic methods are currently used for band removal. METHODS:571 morbidly obese patients underw...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Lattuada E,Zappa MA,Mozzi E,Fichera G,Granelli P,De Ruberto F,Antonini I,Radaelli S,Roviaro G

    更新日期:2007-03-01 00:00:00

  • Changes in measured resting energy expenditure after Roux-en-Y gastric bypass for clinically severe obesity are not related to bypass limb-length.

    abstract:BACKGROUND:Roux-en-Y gastric bypass (RYGB) for clinically severe obesity (CSO) results in a 'paradoxical' response of the measured resting energy expenditure (MREE) in which the MREE remains within the predicted range based upon the Harris-Benedict (HB) equation, despite a significant decrease in caloric intake to 500-...

    journal_title:Obesity surgery

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Flancbaum L,Verducci JS,Choban PS

    更新日期:1998-08-01 00:00:00

  • Dietary habits and body weight at long-term following biliopancreatic diversion.

    abstract:AIM:This study aims to evaluate the role of simple carbohydrates and alcohol intake in determining weight of stabilization at long-term following malabsorptive bariatric surgery. MATERIAL AND METHODS:Sixty patients at more than 2 years following biliopancreatic diversion (BPD) were submitted to an alimentary interview...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Cornicelli M,Noli G,Marinari GM,Adami GF

    更新日期:2010-09-01 00:00:00

  • Gastric bezoar after laparoscopic Roux-en-Y gastric bypass.

    abstract::Gastric bezoar is an uncommon complication following Roux-en-Y gastric bypass (RYGBP). We report two cases of bezoar formation that occurred following laparoscopic RYGBPs. In both cases, the patients presented with abdominal pain, nausea, and "frothy" vomiting. The patients were successfully treated by endoscopic frag...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Pinto D,Carrodeguas L,Soto F,Lascano C,Cho M,Szomstein S,Rosenthal R

    更新日期:2006-03-01 00:00:00

  • Are we operating too late? Mortality Analysis and Stochastic Simulation of Costs Associated with Bariatric Surgery: Reconsidering the BMI Threshold.

    abstract:BACKGROUND:Present guidelines recommend bariatric surgery at BMI ≥ 40 kg/m2 or BMI ≥ 35 kg/m2 with obesity-related morbidity. METHODS:Evidence for cost and mortality/morbidity risk of bariatric surgery and obesity-related diseases was evaluated determining equivalency point of absolute incremental mortality risk by BM...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Sinha AC,Singh PM,Bhat S

    更新日期:2016-01-01 00:00:00

  • Non-alcoholic fatty liver disease and its relationship with the nutritional status of vitamin A in individuals with class III obesity.

    abstract:BACKGROUND:The objective of the present study was to investigate vitamin A nutritional status in individuals with class III obesity through a biochemical indicator (retinol and beta-carotene serum levels), correlating these findings with non-alcoholic fatty liver disease (NAFLD) presence and its risk factors. METHODS:...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Villaça Chaves G,Pereira SE,Saboya CJ,Ramalho A

    更新日期:2008-04-01 00:00:00

  • The effect of Roux-en-Y gastric bypass on zinc nutritional status.

    abstract:BACKGROUND:Researchers have found that zinc nutritional status in obese and diabetic subjects is altered: low zinc concentrations in plasma and erythrocytes, with high urinary zinc excretion, were observed. This study evaluated the effect of Roux-en-Y gastric bypass (RYGBP) on plasma, erythrocyte and urinary zinc conce...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Pires LV,Martins LM,Geloneze B,Tambascia MA,Hadad do Monte SJ,do Nascimento Nogueira N,Santos de Sousa G,Marreiro DN

    更新日期:2007-05-01 00:00:00

  • Dehydroepiandrosterone-sulfate modifies human fatty acid composition of different adipose tissue depots.

    abstract:BACKGROUND:Dehydroepiandrosterone-sulfate (DHEA-S) has been described as a protector agent against obesity-related pathologies, although the mechanism of action is still unknown. We have shown that DHEA-S acts on adipose tissue (AT), altering the fatty acid (FA) profile in rodents. Thus, we could hypothesize that some ...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Hernandez-Morante JJ,Cerezo D,Cruz RM,Larque E,Zamora S,Garaulet M

    更新日期:2011-01-01 00:00:00

  • Is Routine Invasive Monitoring Indicated in Surgery for the Morbidly Obese?

    abstract::BACKGROUND: Morbid obesity is generally considered to be a surgical and anesthetic risk. Some surgeons have advised the routine use of invasive monitoring for morbidly obese individuals undergoing surgery. The purpose of this study was to identify morbidly obese individuals undergoing primary gastric bypass procedures...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Capella JF,Capella RF

    更新日期:1996-02-01 00:00:00

  • Bariatric surgery: low mortality at a high-volume center.

    abstract:BACKGROUND:The American Society of Bariatric Surgery has initiated a Bariatric Surgery Center of Excellence Program and the American College of Surgeons has followed with their Bariatric Surgery Center Network Accreditation Program. These programs postulate that concentration of weight loss operations in high-volume ce...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Ballantyne GH,Belsley S,Stephens D,Saunders JK,Trivedi A,Ewing DR,Iannace V,Davis D,Capella RF,Wasielewski A,Moran S,Schmidt HJ

    更新日期:2008-06-01 00:00:00

  • The bone-adipose axis in obesity and weight loss.

    abstract::Body fat and lean mass are correlated with bone mineral density, with obesity apparently exerting protection against osteoporosis. The pathophysiological relevance of adipose tissue in bone integrity resides in the participation of adipokines in bone remodeling through effects on deposition and resorption. On the othe...

    journal_title:Obesity surgery

    pub_type: 杂志文章,评审


    authors: Gómez-Ambrosi J,Rodríguez A,Catalán V,Frühbeck G

    更新日期:2008-09-01 00:00:00

  • Intermaxillary fixation as co-adjuvant treatment for morbid obesity.

    abstract:BACKGROUND:The effective long-term treatments for morbid obesity is bariatric surgery. However, the associated surgical and anesthetic risks led the authors to evaluate intermaxillary fixation, a less aggressive procedure, as a preoperative treatment in selected patients with morbid obesity. METHODS:22 patients (5 mal...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Vassimon HS,Pigoli DR,de Oliveira Neto FV,Palhares A,Haddad AL,Padovani CR,Mazzoni A,Nogueira CR

    更新日期:2004-06-01 00:00:00

  • Sleeve Gastrectomy Reduces Body Weight and Improves Metabolic Profile also in Obesity-Prone Rats.

    abstract:BACKGROUND:Susceptibility to obesity is associated with a notable inter-individual variation. The aim of the present study was to compare the effectiveness of sleeve gastrectomy (SG) on weight loss and metabolic profile in obesity-prone (OP) rats vs animals that are non-susceptible to obesity (NSO). METHODS:Young male...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Moncada R,Becerril S,Rodríguez A,Méndez-Giménez L,Ramírez B,Catalán V,Gómez-Ambrosi J,Gil MJ,Fernández S,Cienfuegos JA,Valentí V,Frühbeck G

    更新日期:2016-07-01 00:00:00

  • Biomarkers of Colorectal Cancer Risk Decrease 6 months After Roux-en-Y Gastric Bypass Surgery.

    abstract:PURPOSE:The impact of weight loss on obesity-related colorectal cancer (CRC) risk is not well defined. Previous studies have suggested that Roux-en-Y gastric bypass (RYGB) surgery may have an unexpected adverse impact on CRC risk. This study aimed to investigate the impact of RYGB on biomarkers of CRC risk. MATERIALS ...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Afshar S,Malcomson F,Kelly SB,Seymour K,Woodcock S,Mathers JC

    更新日期:2018-04-01 00:00:00

  • Management of a Complicated Internal Herniation After Roux-en-Y Gastric Bypass in a 28-Week Pregnant Woman.

    abstract:BACKGROUND:Small bowel obstruction (SBO) due to internal hernia (IH) is a well-known late complication after laparoscopic Roux-en-Y gastric bypass (LRYGB), with an incidence between 0.5 and 10% as reported by Iannelli et al. (Obes Surg. 17(10):1283-6, 2007). It is reported most frequently 1-2 years after surgery becaus...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Thomopoulos T,Mantziari S,St-Amour P,Uldry E,Suter M

    更新日期:2020-12-01 00:00:00

  • Changes in depression following gastric banding: a 5- to 7-year prospective study.

    abstract:BACKGROUND:Long-term outcomes of gastric banding regarding depression and predictors of change in depression are still unclear. This prospective, controlled study investigated depression and self-acceptance in morbidly obese patients before and after gastric banding. METHODS:A total of 248 morbidly obese patients (mea...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Schowalter M,Benecke A,Lager C,Heimbucher J,Bueter M,Thalheimer A,Fein M,Richard M,Faller H

    更新日期:2008-03-01 00:00:00

  • A Step-by-Step Surgical Technique Video of Revision of Roux-en-Y Gastric Bypass with Limb Distalization.

    abstract::The Roux-en-Y gastric bypass (RYGB) is the second most common bariatric procedure in the USA. Although the RYGB is an effective procedure, some patients will not achieve optimal weight loss or will experience significant weight regain. In this video report, we present a step-by-step surgical technique of RYGB limb dis...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Surve A,Cottam D

    更新日期:2021-01-01 00:00:00

  • Bone mineral density and nutritional profile in morbidly obese women.

    abstract:BACKGROUND:Morbid obesity may be associated with malnutrition. Because it is important to assess the preoperative nutritional/metabolic status and bone mineral density of these patients, this study was designed aiming to evaluate bone metabolism/mineral density and nutritional profile in morbidly obese women. METHODS:...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Casagrande DS,Repetto G,Mottin CC,Schneider R,Rizzolli J,Moretto M,Padoin AV,Schaan BD

    更新日期:2010-10-01 00:00:00

  • Internal hernia as a complication of laparoscopic Roux-en-Y gastric bypass.

    abstract:BACKGROUND:Internal hernia (IH) is a well known complication of Roux-en-Y gastric bypass (RYGBP) which is more frequently encountered when the RYGBP is done laparoscopically. METHODS:Patients with IH were identified from a prospective data-base of morbidly obese patients undergoing bariatric surgery at our center. RE...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Iannelli A,Buratti MS,Novellas S,Dahman M,Amor IB,Sejor E,Facchiano E,Addeo P,Gugenheim J

    更新日期:2007-10-01 00:00:00

  • Prevalence of Vitamin D Depletion, and Associated Factors, among Patients Undergoing Bariatric Surgery in Southern Brazil.

    abstract:BACKGROUND:Hypovitaminosis D is common, before and after gastric bypass surgery. The prevalence of hypovitaminosis D in a large group of candidates for bariatric surgery in Brazil and South America has not been studied. OBJECTIVE:To evaluate the prevalence of hypovitaminosis D and associated factors in patients underg...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Vivan MA,Kops NL,Fülber ER,de Souza AC,Fleuri MASB,Friedman R

    更新日期:2019-10-01 00:00:00

  • Oral liquid L-thyroxine (L-t4) may be better absorbed compared to L-T4 tablets following bariatric surgery.

    abstract::Drug malabsorption is a potential concern after bariatric surgery. We present four case reports of hypothyroid patients who were well replaced with thyroxine tablets to euthyroid thyrotropin (TSH) levels prior to Roux-en-Y gastric bypass surgery. These patients developed elevated TSH levels after the surgery, the TSH ...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Pirola I,Formenti AM,Gandossi E,Mittempergher F,Casella C,Agosti B,Cappelli C

    更新日期:2013-09-01 00:00:00

  • Outcomes of laparoscopic sleeve gastrectomy in patients older than 60 years.

    abstract:BACKGROUND:Morbidity and mortality following laparoscopic sleeve gastrectomy (LSG) occur at acceptable rates, but its safety and efficacy in the elderly are unknown. METHODS:A retrospective review was performed of all patients aged >60 years who underwent LSG from 2008 to 2012. These patients were 1:2 matched, by gend...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Mizrahi I,Alkurd A,Ghanem M,Zugayar D,Mazeh H,Eid A,Beglaibter N,Grinbaum R

    更新日期:2014-06-01 00:00:00

  • A Comparison of Health Professionals' and Patients' Views of the Importance of Outcomes of Bariatric Surgery.

    abstract:BACKGROUND:A comprehensive evaluation of bariatric surgery is required to inform decision-making. This will include measures of benefit and risk. It is possible that stakeholders involved with surgery value these outcomes differently, although this has not previously been explored. This study aimed to investigate and c...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Coulman KD,Howes N,Hopkins J,Whale K,Chalmers K,Brookes S,Nicholson A,Savovic J,Ferguson Y,Owen-Smith A,Blazeby J,By-Band-Sleeve Trial Management Group.,Blazeby J,Welbourn R,Byrne J,Donovan J,Reeves BC,Wordsworth S,An

    更新日期:2016-11-01 00:00:00

  • Laparoscopic Greater Curvature Plication for the Treatment of Obesity: a Systematic Review.

    abstract:BACKGROUND:During the last decade, laparoscopic greater curvature plication (LGCP) has been used as a bariatric procedure for the treatment of obesity, regarded as less invasive and less expensive than other surgical bariatric procedures. We aimed to systematically review the literature and highlight recent clinical da...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: El Soueidy T,Kassir R,Nakhoul M,Balian A,Nunziante M,Safieddine M,Perlemuter G,Lainas P,Dagher I

    更新日期:2020-11-19 00:00:00

  • Achalasia-like disorder after laparoscopic adjustable gastric banding: a reversible side effect?

    abstract::Literature data concerning the effect of laparoscopic adjustable gastric banding (LAGB) on esophageal motility are conflicting. Achalasia-like disorder involving the absence of esophageal peristalsis and impaired esophago-gastric junction (EGJ) is probably under-estimated and can result in failure and band removal. Th...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Robert M,Golse N,Espalieu P,Poncet G,Mion F,Roman S,Boulez J,Gouillat C

    更新日期:2012-05-01 00:00:00

  • Rhabdomyolysis after laparoscopic bariatric surgery.

    abstract:BACKGROUND:Postoperative rhabdomyolysis is an uncommon event. The aim of this study was to determine the incidence of rhabdomyolysis following laparoscopic obesity surgery. METHODS:Rhabdomyolysis was studied prospectively. Over a 6-month period, 66 consecutive patients underwent bariatric surgery (gastric banding (n=5...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Mognol P,Vignes S,Chosidow D,Marmuse JP

    更新日期:2004-01-01 00:00:00

  • Seven cases of gastric perforation in Roux-en-Y gastric bypass patients: what lessons can we learn?

    abstract:BACKGROUND:Patients undergoing Roux-en-Y gastric bypass for the resolution of morbid obesity have significant medical sequelae related to their weight. One of the most common comorbid conditions is joint pain requiring the use of non-steroidal anti-inflammatory medications (NSAIDs). In addition to NSAIDs, patients may ...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Sasse KC,Ganser J,Kozar M,Watson RW,McGinley L,Lim D,Weede M,Smith CJ,Bovee V

    更新日期:2008-05-01 00:00:00

  • Ten years experience with laparoscopic adjustable gastric banding.

    abstract:BACKGROUND:Gastric banding is a safe and efficient bariatric procedure. We report here the results of 591 consecutive gastric bandings in terms of excess weight loss with up to 10 years follow-up and the complications. METHODS:Between June 1996 and September 2006, 591 patients underwent laparoscopic adjustable gastric...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Biagini J,Karam L

    更新日期:2008-05-01 00:00:00