Abstract:
BACKGROUND:The duodenal-jejunal bypass liner (DJBL) represents a novel endoscopic minimally invasive treatment option for obesity-associated type 2 diabetes (T2D), affecting body weight and metabolic control. Until now, the effects of DJBL on cardiovascular risk have never been investigated. METHODS:Between 2012 and 2017, 71 patients with T2D and metabolic syndrome (MS) were recruited for implantation of DJBL for 9-12 months. Within DJBL treatment and a follow-up period of 6 months, patients were analysed for dynamics of cardiovascular biomarkers. Overall cardiovascular risk was estimated by the ADVANCE Risk Engine at time of implantation, explantation and 6 months after explantation of DJBL. RESULTS:DJBL-induced weight loss and improvements in blood sugar control were accompanied by significant decreases of the cardiovascular biomarkers high-sensitive CRP, lipoprotein-associated phospholipase A2 and small dense lipoprotein fraction LDL-4 (p = 0.001, p < 0.001 and p = 0.04, respectively). Estimated overall cardiovascular risk decreased significantly after DJBL implantation and remained stable within 6 months after explantation. CONCLUSIONS:In addition to beneficial effects of DJBL on weight loss, glycaemic control and lipid parameters in patients with MS, this is the first study that could further reveal significant impact on serological cardiovascular biomarkers and estimated CV risk, suggesting putative protective effects of DJBL on CV outcome.
journal_name
Obes Surgjournal_title
Obesity surgeryauthors
Roehlen N,Laubner K,Bettinger D,Schwacha H,Hilger H,Koenig C,Grueninger D,Krebs A,Seufert Jdoi
10.1007/s11695-019-04324-2subject
Has Abstractpub_date
2020-04-01 00:00:00pages
1200-1210issue
4eissn
0960-8923issn
1708-0428pii
10.1007/s11695-019-04324-2journal_volume
30pub_type
杂志文章相关文献
OBESITY SURGERY文献大全abstract::Gastric bypass with jejunal interposition is a version of the distal Roux-en-Y. Ninety cm of the jejunum is interposed between the gastric stoma and the ileum. This new procedure initially was used in super-obese patients mainly to facilitate the gastric anastomosis. ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089293765559584
更新日期:1993-05-01 00:00:00
abstract:PURPOSE:Metabolic and bariatric surgery (MBS) is increasingly performed in patients with previous solid organ transplantation (PSOT). In addition, controversy remains about whether racial disparity in outcomes following MBS exists. Therefore, the aim of this analysis was to determine if race independently predicts outc...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-020-04813-9
更新日期:2020-11-01 00:00:00
abstract::There is no consensus on how to protect the skeleton with adequate supplements in patients who have undergone bariatric operations. The main problem in mineral metabolism is usually related to secondary hyperparathyroidism (2 degrees HPT), often caused by a lack of dietary calcium, magnesium or vitamin D, together wit...
journal_title:Obesity surgery
pub_type: 杂志文章,评审
doi:10.1007/s11695-008-9431-0
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Postoperative staple line leaks and bleeding are the most common reasons for complications in surgical procedures that involve organ resection, such as sleeve gastrectomy. Increasing the safety of these operations requires improving the instruments (endostaplers or endocutters) used for stapling and sectioni...
journal_title:Obesity surgery
pub_type: 信件
doi:10.1007/s11695-012-0792-z
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate the effect of chest physiotherapy (CP) applied to patients undergoing bariatric surgery on pulmonary functions, dyspnea levels, functional capacity, and quality of life. METHODS:The patients were randomized and divided into two groups each comprising 74 patients. CP and...
journal_title:Obesity surgery
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11695-019-04165-z
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Obesity is an independent risk factor for hypertension and chronic kidney disease. During the first months after bariatric surgery, an improvement of sodium excretion has been described. The aim of this work was to study the influence of bariatric surgery on sodium excretion at more than a year after the int...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-012-0764-3
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Laparoscopic adjustable gastric banding is a popular bariatric operation. Unfortunately, long-term complications such as slippage, infection, and intragastric migration (erosion) may occur. With erosion, band removal is mandatory. Options to prevent weight regain are delayed implantation of a new band, or co...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089204322917918
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Obesity is an independent cardiovascular risk factor and a catalyst of other cardiovascular risk factors, such as hypertension, dyslipidemia, type 2 diabetes mellitus (DM2) and metabolic syndrome. METHODS:We analyzed cardiovascular risk in obese patients before and after sleeve gastrectomy (SG). To this end...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-016-2441-4
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Severely obese women have higher obstetric risks and poorer neonatal outcomes. Weight loss reduces obstetric risk. The introduction of a laparoscopically-placed adjustable gastric band, a safe and effective method of weight loss, has given us the ability and responsibility to adjust the band in relation to p...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089201321454123
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND AND AIMS:The mechanism of weight loss with the intra-gastric balloon (IGB) is thought to be a decrease in gastric emptying (GE); however the evidence is conflicting. Nausea, abdominal pain, and gastroesophageal reflux disease (GERD) can cause intolerance resulting in early removal. This is demoralizing for t...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-019-04039-4
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Obesity is a worldwide epidemic associated to comorbidities and increased mortality. Because it is chronic and recurrent and has little response to clinical measures, surgical treatment (bariatric surgery) is a therapeutic option frequently used. Different surgical complications have been associated with thi...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-008-9780-8
更新日期:2009-08-01 00:00:00
abstract::The complications of spinal cord injury are exaggerated with obesity, and create complex medical and socioeconomic issues. Despite the well-documented advantages of bariatric surgery in reducing the morbidity of obesity, this option has not been routinely offered to obese patients with spinal cord injuries. We describ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089206778026389
更新日期:2006-08-01 00:00:00
abstract::BACKGROUND: Morbid obesity is generally considered to be a surgical and anesthetic risk. Some surgeons have advised the routine use of invasive monitoring for morbidly obese individuals undergoing surgery. The purpose of this study was to identify morbidly obese individuals undergoing primary gastric bypass procedures...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089296765557268
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND:Various techniques of laparoscopic Roux-en-Y gastric bypass have been described. We completely standardized this procedure to minimize its sometimes substantial morbidity and mortality. This study describes our experience with the standardized fully stapled laparoscopic Roux-en-Y gastric bypass (FS-LRYGB) an...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-009-9933-4
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:The BioEnterics Intragrastric Balloon (BIB) together with restricted diet has been used for the treatment of obesity and morbid obesity. METHODS:A prospective study was conducted on 100 patients who had undergone the BIB procedure between February 2005 and February 2007. RESULTS:Mean age, mean weight, and ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-008-9565-0
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:Bariatric surgery is the most effective treatment for morbid obesity. The present study aimed to assess three bariatric procedures with different mechanisms of actions; sleeve gastrectomy (SG), one-anastomosis gastric bypass (OAGB), and single anastomosis sleeve ileal (SASI) bypass, in terms of efficacy and saf...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-020-05159-y
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:The BioEnterics Intragastric Balloon (BIB) is a saline-filled balloon recommended to remain in the gastric cavity for a maximum of 6 months. Is this short period sufficient to change patients' lifestyle and eating practices to maintain weight reduction after BIB removal? METHODS:100 patients who received a ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/0960892054222894
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Current evidence suggests that local anesthetic wound infiltration should be employed as part of multimodal postoperative pain management. There is scarce data concerning the benefits of this anesthetic modality in laparoscopic weight loss surgery. Therefore, we analyzed the influence of trocar site infiltra...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-015-1761-0
更新日期:2016-02-01 00:00:00
abstract:INTRODUCTION:Weight regain after laparoscopic Roux-en-Y gastric bypass (RYGB) occurs in up to 35% of patients. Revisional surgery may be applied. Conversion from RYGB to a long biliopancreatic limb (BPL) RYGB is a potential option for revisional surgery and short-term results are promising. METHODS:All patients who un...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-019-04348-8
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Obesity is increasing in Turkey. The first experience with vertical banded gastroplasty (VBG) with regular intermediate-term follow-up in the Aegean Region of Turkey is presented. METHODS:From November 1993 to August 1999, 40 morbidity obese patients underwent VBG. The patients were evaluated on the basis o...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089201321209387
更新日期:2001-08-01 00:00:00
abstract::A new technique of vertical gastroplasty was applied in 50 morbidly obese patients. Eight of them were male and 42 female with a mean age of 34 years (range 2058). The mean excess body weight was 77 kg (range 52-133) and the mean Body Mass Index 51 kg/m(2) (range 42-81). Under direct vision the hepatogastric and gastr...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089294765558322
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Laparoscopic sleeve gastrectomy (LSG) restricts gastric volume to achieve weight loss. We aimed to compare the efficacy of LSG with and without antrectomy for achieving weight loss. METHODS:The prospective randomized study comprised 127 obese patients that underwent either LSG with antrectomy (2 cm to pylor...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-019-04177-9
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:The components of esophageal function important to success with laparoscopic adjustable gastric banding (LAGB) are not well understood. A pattern of delayed, however, successful bolus transit across the LAGB is observed. METHODS:Successful LAGB patients underwent a high-resolution video manometry study in w...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-009-0063-9
更新日期:2010-09-01 00:00:00
abstract:UNLABELLED:Laparoscopic gastric banding and Roux-en-Y gastric bypass are widely used for the treatment of morbid obesity. The impact of these two procedures on health-related quality of life has not been analyzed in comparative studies. METHODS:A matched-pair analysis of a prospectively collected database was performe...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-008-9522-y
更新日期:2008-12-01 00:00:00
abstract::Obesity is linked to inferior transplant outcome. Bariatric surgery (BS) is an established treatment of morbid obesity. We provide an overview on BS in the field of kidney (KT) and liver transplantation (LT). In end-stage renal disease (ESRD) and KT patients, BS seems safe and feasible. Complication rates were slightl...
journal_title:Obesity surgery
pub_type: 杂志文章,评审
doi:10.1007/s11695-017-2854-8
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Long-term outcomes of gastric banding regarding depression and predictors of change in depression are still unclear. This prospective, controlled study investigated depression and self-acceptance in morbidly obese patients before and after gastric banding. METHODS:A total of 248 morbidly obese patients (mea...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-007-9316-7
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Breast reduction surgery is common in females; however, in males it is mainly due to gynecomastia. After weight reduction following obesity surgery, it is a problem in women, but also in some men. METHOD:One patient is described in whom the weight reduction declined from BMI 52 to BMI 36 after vertical band...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089299765552819
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND AND AIM:Staple line complications and axial rotation of the gastric tube after sleeve gastrectomy are well-recognized complications of the procedure. The present study aims to investigate the role of staple line inversion and distal fixation to the transverse mesocolon in reducing these complications. PATIE...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-016-2277-y
更新日期:2017-02-01 00:00:00
abstract:INTRODUCTION:Laparoscopic single anastomosis gastric bypass (SAGB) is increasingly performed for morbidly obese patients. AIM OF WORK:This pilot study aims primarily at evaluating the incidence of bile gastritis after SAGB. The occurrence of reflux oesophagitis and reflux symptoms were also assessed. PATIENTS AND MET...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-017-2885-1
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:The objective of the study is to analyze procedural and safety outcomes associated with bariatric surgery and describe the characteristics of patients undertaking bariatric procedures in England between April 2006 and March 2012. METHODS:This is a retrospective cohort study of all adult patients in England ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-017-2978-x
更新日期:2018-04-01 00:00:00