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Sugar Detection Threshold After Laparoscopic Sleeve Gastrectomy in Adolescents.

Abstract：

INTRODUCTION:Obesity in young people is one of the most serious public health problems worldwide. Moreover, the mechanisms preventing obese adolescents from losing and maintaining weight loss have been elusive. Laparoscopic sleeve gastrectomy (LSG) is successful at achieving long-term weight loss in patients across all age groups, including children and adolescents. Anecdotal clinical observation as well as evidence in rodents suggests that LSG induces a shift in preference of sugary foods. However, it is not known whether this shift is due to a change in the threshold for gustatory detection of sucrose, or whether LSG induces behavioral change without affecting the gustatory threshold for sugar. AIMS:The objective of this study was to determine whether adolescents who undergo LSG experience a change in their threshold for detecting sweet taste. METHODS:We studied the sucrose detection threshold of 14 obese adolescents (age 15.3 ± 0.5 years, range 12-18) who underwent LSG 2 weeks before surgery and at 12 and 52 weeks after surgery. Matched non-surgical subjects were tested on two occasions 12 weeks apart to control for potential learning of the test that may have confounded the results. Seven sucrose concentrations were used and were tested in eight blocks with each block consisting of a random seven sucrose and seven water stimuli. The subjects were asked to report whether the sample contained water or not after they tasted 15 ml of the fluid for 10 s. RESULTS:The bodyweight of the LSG group decreased from 136.7 ± 5.4 to 109.6 ± 5.1 and 86.5 ± 4.0 kg after 12 and 52 weeks, respectively (p < 0.001). There was no significant difference after surgery in taste detection threshold of patients after LSG (p = 0.60), and no difference was observed comparing the taste detection threshold of the LSG group with the non-surgical controls (p = 0.38). CONCLUSION:LSG did not affect the taste detection threshold for sucrose, suggesting that the shift in preference for sugary foods may be due to factors other than fundamental changes in taste sensitivity.

journal_name

Obes Surg

journal_title

Obesity surgery

authors

Abdeen GN,Miras AD,Alqhatani AR,le Roux CW

doi

10.1007/s11695-017-2999-5

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

1302-1307

issue

eissn

0960-8923

issn

1708-0428

pii

10.1007/s11695-017-2999-5

journal_volume

pub_type

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Sugar Detection Threshold After Laparoscopic Sleeve Gastrectomy in Adolescents.