Abstract:
BACKGROUND:The duodenal-jejunal bypass liner (DJBL) is an endoscopically placed device designed to achieve weight loss and improve glycemic control in obese patients. Previous studies report promising results but typically included small patient numbers and short follow-up. This study aims to determine the safety and effectiveness of the device. METHODS:Study design: A series of all patients treated by the DJBL at our institutions. OUTCOME MEASUREMENTS:Weight loss, biochemical measures, complications. RESULTS:Between July 2012 and March 2015, 114 consecutive patients were treated for a mean 51.1 weeks (standard deviation (SD) 19.9 weeks). Mean total body weight change from baseline was 12.0 kg (SD 8.5 kg, p < 0.001). Mean percent total body weight loss (%TWL) was 10.5% (SD 7.3%). Mean HbA1c was not significantly improved, but of 10 patients on insulin, 4 ceased insulin and 4 reduced insulin dosages. There was a significant decrease in hemoglobin and total cholesterol and a significant increase in serum alkaline phosphatase. Seventy-four percent of patients experienced at least one adverse event, some of them serious including 6 device obstructions, 5 gastrointestinal hemorrhages, 2 liver abscesses, and 1 acute pancreatitis. Seventy-four percent of patients experienced weight gain after removal with a mean 4.5 ± 6.1 kg (p < 0.0001) within the first 6 months after explantation. CONCLUSIONS:The DJBL provides significant but highly variable weight loss. Glycemic control was variable. Most insulin-requiring T2DM patients ceased or reduced insulin. Most patients experience an adverse event and most regain significant weight after device removal. Major adverse events can occur, including the potentially life-threatening complications of hepatic abscess and gastrointestinal hemorrhage.
journal_name
Obes Surgjournal_title
Obesity surgeryauthors
Forner PM,Ramacciotti T,Farey JE,Lord RVdoi
10.1007/s11695-017-2939-4subject
Has Abstractpub_date
2017-12-01 00:00:00pages
3306-3313issue
12eissn
0960-8923issn
1708-0428pii
10.1007/s11695-017-2939-4journal_volume
27pub_type
杂志文章相关文献
OBESITY SURGERY文献大全abstract::The complications of spinal cord injury are exaggerated with obesity, and create complex medical and socioeconomic issues. Despite the well-documented advantages of bariatric surgery in reducing the morbidity of obesity, this option has not been routinely offered to obese patients with spinal cord injuries. We describ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089206778026389
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:The definition of success and failure of a bariatric procedure should include weight loss as well as improvement in comorbidity and quality of life assessment. The Bariatric Analysis and Reporting Outcome System (BAROS), introduced by Oria and Moorhead in 1997, seems to provide a standard for comparison in t...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089298765554052
更新日期:1998-10-01 00:00:00
abstract::Duodenal mucosal resurfacing (DMR) is an innovative endoscopic bariatric and metabolic therapy (EBMT) emerging in recent years. It uses the duodenum to achieve better glycemic and weight control. This study aimed to evaluate in a critical and systematic way the metabolic effects of this procedure. Electronic searches ...
journal_title:Obesity surgery
pub_type: 杂志文章,评审
doi:10.1007/s11695-020-05170-3
更新日期:2021-01-08 00:00:00
abstract::A 33-year-old, morbidity obese woman underwent a laparoscopic Roux-en-Y gastric bypass in November 2004. She presented 18 months later with a history of recurrent pain in the upper region of the abdomen and severe vomiting. Radiologic and endoscopic evaluations revealed wall thickening in the transverse colon and a so...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-007-9189-9
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:The aim of this study was to assess the incidence of intragastric migration of the Swedish adjustable gastric band (SAGB) and to evaluate the safety and effectiveness of gastroscopic band removal. METHODS:Between January 1996 and December 2001, 454 patients (381 women, 73 men) underwent a laparoscopic SAGB ...
journal_title:Obesity surgery
pub_type: 临床试验,杂志文章
doi:10.1381/096089202321088183
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:The Roux-en-Y gastric bypass (RYGB) is one of the most commonly performed procedures for surgical weight loss. It has been shown that overweight may be associated with an increased risk of gastric cancer. However, the risk of remnant gastric cancer after RYGB has not been defined yet and the development of n...
journal_title:Obesity surgery
pub_type: 杂志文章,评审
doi:10.1007/s11695-019-03892-7
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Gastric banding is a safe and efficient bariatric procedure. We report here the results of 591 consecutive gastric bandings in terms of excess weight loss with up to 10 years follow-up and the complications. METHODS:Between June 1996 and September 2006, 591 patients underwent laparoscopic adjustable gastric...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-008-9470-6
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Biliopancreatic diversion (BPD) has been shown to be one of the most effective techniques for losing weight, although the relationship between body composition and diet after the procedure is not well known. Our aim was to assess dietary changes and their effects on body composition. METHODOLOGY:This longit...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-015-1658-y
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Bariatric surgery is the most effective treatment for morbid obesity and associated medical co morbidities. There is currently minimal surgical treatment penetration of this widespread disease. BLIS has been able to improve the access to bariatric surgery for cash-pay patients by alleviating concern about th...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-012-0745-6
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Surgical revision rates are high, reaching 41% at 10 years after Laparoscopic gastric band (LAGB). Surgical revision may include re-banding, laparoscopic sleeve gastrectomy (LSG), duodenal switch (DS), or laparoscopic Roux-en-Y gastric bypass (LRYGB). LRYGBP has been proposed as the procedure of choice after...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-020-05027-9
更新日期:2020-10-14 00:00:00
abstract:BACKGROUND:Cognitive dysfunction is associated with reduced postoperative weight loss up to 2 years following surgery, though the role of cognition at more extended follow-up is not yet understood. Thirty-six months following bariatric surgery, we retrospectively compared obese and non-obese patients on 12-week postope...
journal_title:Obesity surgery
pub_type: 杂志文章,多中心研究
doi:10.1007/s11695-014-1205-2
更新日期:2014-07-01 00:00:00
abstract::Bariatric surgery is the most effective modality of achieving weight loss as well as the most effective treatment for type 2 diabetes mellitus (T2DM). Glucose-dependent insulinotropic polypeptide (GIP) is an incretin and is implicated in the pathogenesis of obesity and T2DM. Its role in weight loss and resolution of T...
journal_title:Obesity surgery
pub_type: 杂志文章,评审
doi:10.1007/s11695-010-0305-x
更新日期:2011-02-01 00:00:00
abstract:PURPOSE:Growing evidence in the literature suggests that obesity is capable of altering reproductive hormone levels and male fertility. Effects on classic semen parameters and sperm DNA fragmentation (SDF), however, have not been properly established. Additionally, the impact of bariatric surgery (BS) on those paramete...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-020-04851-3
更新日期:2020-12-01 00:00:00
abstract:INTRODUCTION:One-anastomosis-mini-gastric bypass (OAGB-MGB) is the second most popular gastric bypass procedure with remarkable weight loss results and comorbidity resolution rates. However, some concerns remain regarding its postoperative complications, including protein-calorie malnutrition (PCM). We hereby report ou...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-019-03741-7
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Most of the weight loss with the BioEnterics intragastric balloon (BIB) has occurred during the first 3-4 months. This study aimed to evaluate the effect of initial weight loss on long-term weight maintenance. METHODS:From 2008 to 2011, 50 patients who had mean body mass index (BMI) of 44.7 ± 12.4 kg/m(2) u...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-013-0876-4
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Laparoscopic gastric bypass (LGBP) is being performed widely as a treatment of choice for morbid obesity. Advantages over open gastric bypass (OGBP) have not been well documented in controlled studies. The aim of this study is to evaluate the early postoperative outcomes after LGBP and OGBP using a matched p...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089203765887624
更新日期:2003-06-01 00:00:00
abstract::Laparoscopic adjustable gastric banding is a commonly performed bariatric operation worldwide. The presence of an anatomical variation like situs inversus demands preoperative assessment and preparedness on the part of the surgeon. We report a laparoscopic gastric banding performed on a morbidly obese patient with sit...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-008-9546-3
更新日期:2008-12-01 00:00:00
abstract::A new technique of vertical gastroplasty was applied in 50 morbidly obese patients. Eight of them were male and 42 female with a mean age of 34 years (range 2058). The mean excess body weight was 77 kg (range 52-133) and the mean Body Mass Index 51 kg/m(2) (range 42-81). Under direct vision the hepatogastric and gastr...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089294765558322
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Many operations are currently used for morbid obesity, and every procedure appears to have advantages, drawbacks and failures. Re-operation is a part of bariatric surgery practice that is necessary in the event of failure. We analyzed the reasons for failure in the bariatric re-operation group. METHODS:From...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089200321593733
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:More should be known about the spectrum of endoscopic abnormalities and treatments in patients with upper gastrointestinal (UGI) symptoms after laparoscopic bariatric surgery. METHODS:Patients referred for endoscopic evaluation of UGI symptoms after laparoscopic bariatric surgery were studied. Clinical mani...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089206778392176
更新日期:2006-09-01 00:00:00
abstract::There is no consensus on the monitoring of liver function tests after Roux-en-Y gastric bypass (RYGB). Since the main objective of such monitoring would be to diagnose early those who will eventually develop liver failure after RYGB, we performed a systematic review on this topic. An extensive search of literature rev...
journal_title:Obesity surgery
pub_type: 杂志文章,评审
doi:10.1007/s11695-016-2280-3
更新日期:2016-10-01 00:00:00
abstract::Roux-en-Y gastric bypass (RYGBP) is one of the most commonly performed surgical procedures for morbid obesity. Several complications that may develop in the short- and long-term have been reported. We present a patient who presented with cancer in the bypassed stomach 8 years after RYGBP. Although the development of t...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/0960892053576668
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Omental adipose tissue specimens of female rats that were fed a high fat (HF) diet were evaluated stereologically and histopathologically. To our knowledge, there is no stereological study on numerical density, nuclear height and volume of adipocytes in omental adipose tissue in the female rat fed a HF diet ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089206778869942
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:Laparoscopic techniques have been used to perform the Roux-en-Y gastric bypass (RYGBP). The gastrojejunostomy may be constructed using an end-to-end anastomosis (EEA) stapler. Most reports describe passing the EEA anvil transorally using an esophagogastroscope and a pull-wire technique. METHOD:We describe p...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089200321629139
更新日期:2000-08-01 00:00:00
abstract::A morbidly obese 42-year-old woman presented with a 1-week history of left chest pain. She had undergone laparoscopic adjustable gastric banding 16 months earlier with a body mass index (BMI) of 49.2 kg/m2. Diagnostic workup revealed a large left pleural empyema and ruled out band slippage. At left thoracotomy, a misd...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-007-9374-x
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:The objective of the study is to analyze procedural and safety outcomes associated with bariatric surgery and describe the characteristics of patients undertaking bariatric procedures in England between April 2006 and March 2012. METHODS:This is a retrospective cohort study of all adult patients in England ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-017-2978-x
更新日期:2018-04-01 00:00:00
abstract::The purpose of this study is to evaluate the food intolerance after banded Roux-en-Y gastric bypass (RYGB), correlating the data of food ingestion. METHODS: This is an observational prospective study, which evaluated the individuals before and 3, 6, and 12 months after banded RYGB. We performed an anthropometric evalu...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-018-3544-x
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Laparoscopic sleeve gastrectomy (LSG) has been introduced as a multipurpose restrictive procedure for obese patients. Variations of the surgical technique may be important for the late results. METHODS:50 patients submitted to LSG from January 2005 to December 2006 were studied. Mean age was 38.2 years, pre...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-008-9421-2
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Obesity is an independent risk factor for cardiovascular disease, especially in its morbid form. Bariatric surgery is an effective therapeutic option for sustained weight loss. However, there is no consensus in these cases regarding the performance of functional tests for preoperative evaluations. The aim of...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-008-9692-7
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Obesity is considered as a risk factor for many functional digestive disorders. The aim of the present study was to evaluate the prevalence and the association of functional digestive symptoms affecting the upper and the lower digestive tract in patients eligible for bariatric surgery. METHODS:Before surger...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-011-0396-z
更新日期:2012-03-01 00:00:00