Abstract:
:The effect of atrial pacing on intracoronary thromboxane production was investigated in 35 patients with stable (n = 19) or unstable (n = 16) angina. Arterial and coronary sinus thromboxane B2, the stable metabolite of thromboxane A2, myocardial lactate extraction and thermodilution coronary sinus flow were measured before, during and immediately after atrial pacing until the onset of angina. Pacing did not significantly increase coronary sinus thromboxane B2 (rest, 233 +/- 107 pg/ml; pacing, 249 +/- 154 pg/ml; postpacing, 330 +/- 309 pg/ml) (mean +/- standard deviation) despite a moderate increase in arterial thromboxane B2 (rest, 270 +/- 170 pg/ml; pacing, 387 +/- 364 pg/ml; postpacing, 446 +/- 420 pg/ml) (all changes probability [p] less than 0.05). A positive transmyocardial thromboxane B2 gradient, suggesting intracoronary thromboxane A2 production, occurred in only five patients at rest (gradient = 60 +/- 35 pg/ml). During pacing, a transmyocardial thromboxane B2 gradient was not observed despite myocardial lactate production in 18 patients. A postpacing gradient was observed in eight patients (gradient = 284 +/- 349 pg/ml). These gradients were significantly more frequent in patients who produced lactate during pacing (7 of 18) than in patients without lactate production (1 of 17) (p less than 0.05). In patients with and without a postpacing gradient, coronary vascular resistance decreased with pacing and returned to rest levels immediately after pacing, suggesting that a postpacing thromboxane gradient does not significantly alter coronary tone. These data suggest that: 1) pacing-induced angina is usually not associated with substantial intracoronary thromboxane A2 production; 2) in a minority of patients who develop intracoronary thromboxane A2 production, the amount is small and does not produce significant coronary vasoconstriction.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Martin JL,Wilson JR,Burch JW,Untereker WJ,Laskey W,Ferraro N,Hirshfeld JW Jrdoi
10.1016/s0735-1097(83)80129-6subject
Has Abstractpub_date
1983-05-01 00:00:00pages
1194-200issue
5eissn
0735-1097issn
1558-3597pii
S0735-1097(83)80129-6journal_volume
1pub_type
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journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-03-15 00:00:00
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更新日期:2010-03-30 00:00:00
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更新日期:2011-07-05 00:00:00
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更新日期:1989-03-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2005-06-07 00:00:00
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更新日期:2003-04-16 00:00:00
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更新日期:2005-01-18 00:00:00