Abstract：
:Although cyclosporine (CsA) has been thought to act primarily on the afferent phase of the immune response, we can demonstrate that it also acts at the efferent phase. The effect of CsA on lymphocyte recruitment (LR), regional blood flow (RBF), and vascular permeability (VP) was studied in paired, healed, subcutaneously placed urethane sponge grafts inoculated with specifically sensitized lymphocytes (SSLs) and allogeneic target cells. Intravenous injection of 111In-labelled unsensitized lymphocytes, 86RbCl and 125I-labelled albumin were used to assess LR, RBF, and VP, respectively. Suspensions of SSL and targets in CsA at 10 and 1 microgram/ml prior to graft inoculation markedly reduce the preferential increase in LR to the site of interaction between SSLs and targets bearing the sensitizing alloantigen (P less than 0.002 for both). Similarly, CsA blocks the preferential increase in RBF (P = 0.017) and VP (P less than 0.002) to the graft site. These effects persist for at least 24 hours. If SSLs and targets are washed after incubation with CsA, LR is still reduced. These results are consistent with the idea that cell-bound CsA blocks the elaboration of lymphokines which results from the interaction between SSLs and specific alloantigen in vivo. These lymphokines increase RBF and VP and are accompanied by an increase in LR. Inhibition of these vascular effects may prevent the recruitment of additional lymphocytes to the graft site. CsA may, therefore, prevent or interrupt allograft rejection by blocking amplification of the rejection mechanism at the graft site.
journal_name
Surgeryjournal_title
Surgeryauthors
Hanto DW,Harty JT,Hoffman R,Simmons RLsubject
Has Abstractpub_date
1983-08-01 00:00:00pages
218-24issue
2eissn
0039-6060issn
1532-7361pii
0039-6060(83)90095-8journal_volume
94pub_type
杂志文章相关文献
SURGERY文献大全abstract：:Experiments were performed to determine whether thyroid-stimulating hormone (TSH) receptors coupled to adenylate cyclase are present in both benign and differentiated malignant thyroid tumors, and to identify abnormalities in the TSH receptor-adenylate cyclase system in neoplastic thyroid tissue. TSH binding and adeny...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-08-01 00:00:00
abstract：BACKGROUND:Less invasive operations such as laparoscopic surgery have been developed for treating gastrointestinal malignancies. However, the advantages of video-assisted thoracoscopic surgery for esophageal cancer (VATS-e) with regard to postoperative morbidity and mortality remains controversial. METHODS:We investig...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2011.12.006
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:The long-term outcome of bilateral adrenalectomy in the management of patients with Cushing's syndrome has not been previously well studied. METHODS:We reviewed our long-term results in 34 patients treated with bilateral adrenalectomy between 1983 and the present. Fourteen presented with occult or metastati...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:A case of pneumatosis cytoides intestinalis associated with jejunoileal bypass is reported. The association of increased colonic gas, secondary to fermentation of undigested lactose in the colon, and the reflux of the excessive gas into the excluded segment of small bowel and dissection of the gas into the bowel wall ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1976-04-01 00:00:00
abstract：INTRODUCTION:The purpose of this study was to compare faculty ratings between live versus video-recorded resident performances and faculty versus skills coaches' ratings of video-recorded resident performances. METHODS:PGY1 residents were observed, video-recorded, and rated during a Verification of Proficiency examina...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2012.03.016
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Apolipoprotein J (ApoJ) is expressed after vascular injury and remodeling and may inhibit endothelial cell activation in the vascular wall. Recently, ApoJ was identified as upregulated in hyperplastic lesions after prosthetic arterial grafting. This study analyzed the effect of ApoJ on human umbilical vein e...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2001.115823
更新日期：2001-08-01 00:00:00
abstract：BACKGROUND:This study was designed to compare the effects of hyperpolarizing versus depolarizing cardioplegic solutions on the coronary vasomotor regulation, specifically focusing on coronary myoplasmic Ca2+-myosin light chain (MLC) phosphorylation pathway and beta-adrenergic signal transduction. METHODS:With the use ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2000.107417
更新日期：2000-08-01 00:00:00
abstract：BACKGROUND:Patients with locally advanced pancreatic cancer have historically been considered inoperable. The purpose of this report was to determine resectability rates for patients with locally advanced pancreatic cancer based on our recently described definitions of type A and type B locally advanced pancreatic canc...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.09.012
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:The Michigan Surgical Home and Optimization Program is a structured, home-based, preoperative training program targeting physical, nutritional, and psychological guidance. The purpose of this study was to determine if participation in this program was associated with reduced hospital duration of stay and hea...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2016.12.021
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:Living-donor liver transplantation has become a legitimate alternative to cadaveric liver transplantation. However, information on the perioperative management of donors is still scarce. METHODS:Between October 1996 and May 2001, 52 consecutive living-donor liver transplantations have been performed at the ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2002.119576
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:The intestinal epithelial tight junction restricts the paracellular permeation of ions and nonelectrolytes. We hypothesized that this function could be altered or disrupted during cellular adenosine triphosphate (ATP) depletion (chemical hypoxia). METHODS:T84 monolayers grown on permeable supports were stud...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1994-08-01 00:00:00
abstract：:Transplantation of the pancreaticoduodenal allograft (PDA) has recently been advocated as a technique that is superior to the use of the segmental allograft. However, the effect of simple cold storage preservation on the PDA has not been studied. We investigated the effect of 24 and 4 hours of cold storage in Eurocoll...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1986-02-01 00:00:00
abstract：:Peripheral lymphocytes, T cells, and T cell subsets of 141 consecutive patients with colorectal cancer were measured preoperatively to determine whether infectious complications could be predicted from derangements of T cell subsets. T cell subset abnormalities reportedly precede sepsis in patients with burn injuries....
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1988-02-01 00:00:00
abstract：INTRODUCTION:A diverting stoma is often performed at the time of low anterior resection (LAR) for rectal cancer after neoadjuvant chemoradiation (nCRT) to protect the anastomosis. The aim of this study was to compare surgical outcomes in large cohorts of mid-high rectal cancer patients undergoing LAR after nCRT with an...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.02.026
更新日期：2015-09-01 00:00:00
abstract：:We studied 28 patients who had undergone 30 operations for pheochromocytoma since 1964. The tumor types included bilateral, extra-adrenal, malignant, recurrent, and multiple endocrine neoplasia, with 20 tumors confined to the adrenal gland. The preoperative studies used to localize the tumor included ultrasonography, ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1985-11-01 00:00:00
abstract：BACKGROUND:A redundant publication is one which duplicates previous, simultaneous, or future publications by the same author or group or, alternatively, could have been combined with the latter into one paper. As there is no information about the extent of this problem in the surgical literature, we set out to assess t...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2001.114549
更新日期：2001-06-01 00:00:00
abstract：BACKGROUND:The present study evaluates 111In-pentetreotide scanning as a method for detection of gastrinomas. Operative findings serve as the benchmark for comparison of the efficacy of 111In-pentetreotide versus conventional imaging studies. METHODS:Twelve patients (seven female and five male; age, 37 to 80 years) wi...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(05)80121-7
更新日期：1995-12-01 00:00:00
abstract：BACKGROUND:Although systems of 3-dimensional image-guided surgery are a valuable adjunct across numerous procedures, differences in organ shape between that reflected in the preoperative image data and the intraoperative state can compromise the fidelity of such guidance based on the image. In this work, we assessed in...
journal_title：Surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.surg.2017.04.020
更新日期：2017-09-01 00:00:00
abstract：:Although well accepted in pediatric patients, nonoperative management of blunt hepatic trauma in adults remains controversial. From January 1981 through May 1987, 66 adults were identified with blunt hepatic trauma that had been confirmed by abdominal exploration or abdominal computed tomography (CT): 46 underwent imm...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1988-10-01 00:00:00
abstract：:Between July 1973 and September 1988, 119 patients with hepatocellular carcinoma underwent hepatic resection at Keio University Hospital, Tokyo. Hepatic resection was performed not only for patients with liver cirrhosis and obstructive jaundice but also for patients with advanced disease. Eighty (67.2%) of the 119 pat...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
abstract：:Since 1966, 29 patients with recurrent carotid artery stenosis have been encountered. The mean (+/- SEM) internal between initial carotid endarterectomy and secondary presentation was 67.5 +/- 9.2 months (range 6 to 180 months). There was a disproportionate number of women with recurrent stenosis. The mean age at init...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1983-02-01 00:00:00
abstract：:With advances in clinical immunosuppression, results in organ transplantation continue to improve. During a 52-month period, 507 cadaver renal transplants were performed, including 435 primary and 72 nonprimary transplants. All patients were managed with quadruple immunosuppression (prednisone, azathioprine, sequentia...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1988-10-01 00:00:00
abstract：:The intravenous infusion of amino acid and carbohydrate solutions is a well-established technique for nutritional support of the pediatric surgical patient. By using peripheral veins for total parenteral nutrition (TPN), weight gain can be achieved and the complications of central venous catheters avoided. Over a 2-ye...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1979-09-01 00:00:00
abstract：BACKGROUND:Adhesion of polymorphonuclear leukocytes (PMNs) to endothelial cells is mediated partially by CD11/CD18 integrins. The purpose of this study was to define (1) the response of PMNs to anti-CD18 monoclonal antibody binding, and (2) the mechanism responsible for anti-CD18 monoclonal antibody-mediated decreases ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：:Two patients with hepatorenal syndrome were treated by insertion of a peritoneovenous shunt. The renal deficit was corrected rapidly in both cases. A 62-year-old woman with a slow onset syndrome with urine output of 100 to 150 ml/day and urinary sodium excretion of 1 mEq/day responded with large volume urinary output ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1977-09-01 00:00:00
abstract：BACKGROUND:Right portal vein embolization has become popular in preparation for right hepatic lobectomy. However, right trisegment portal vein embolization (R3PE) is not well established. METHODS:We performed R3PE in 15 patients with biliary tract carcinoma and 1 patient with primary sclerosing cholangitis. We used 2 ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2000.101273
更新日期：2000-02-01 00:00:00
abstract：BACKGROUND:Parastomal hernia (PH) is a frequent complication of stoma formation, and recurrence after repair is common. A laparoscopic modified Sugarbaker technique (SB) may decrease the recurrence of PH compared with other methods. METHODS:A retrospective review, approved by the institutional review board, of patient...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.04.052
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Few studies discuss causes and outcomes of peritonitis in low-income settings. This study describes epidemiology of patients with peritonitis at a Rwandan referral hospital. Identification of risk factors associated with mortality and unplanned reoperation could improve management of peritonitis. METHODS:Da...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2016.08.036
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:The incidence of reoperation for adhesive bowel obstruction after general abdominal surgery is 2.5% and carries a considerable risk of mortality and morbidity. Adhesions account for 56% of all cases of bowel obstruction. Most epidemiologic knowledge regarding adhesive bowel obstruction is derived from data o...
journal_title：Surgery
pub_type： 临床试验,杂志文章
doi：10.1016/j.surg.2015.11.016
更新日期：2016-05-01 00:00:00
abstract：:From 1979 to 1990, 33 children required operative treatment for pancreatitis. Causes included ductal abnormalities (12 children), trauma (10 children), idiopathic (four children), gallstones (three children), drug-induced (three children), and tumor (one child). This study reviews the characteristics and outcome of th...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
