Abstract：
:It is well known that the administration of phosphodiesterase type-5 inhibitors (PDE5-Is) may improve erectile function (EF) recovery after bilateral nerve-sparing radical prostatectomy (BNSRP). The aim of our study was to identify predictors of the use of a high number of PDE5-Is (one or more per week) after surgery among 184 patients taking proerectile medications on demand. At a mean follow-up of 22.7 months, 116 patients (63%) recovered EF. Overall, EF recovery rates at 1- and 2- year follow-up were 47.3% and 65.4%, respectively. Overall, 43 (23.4%) patients used one or more PDE5-Is per week. Preoperative EF was the only predictor of the use of one or more PDE5-Is per week after BNSRP. This held true even after adjusting our analyses for age at surgery, body mass index and EF at 1 month after surgery. Particularly, patients fully potent before surgery had roughly 2.1-fold higher probability of using one or more pills per week compared with their counterparts with some degree of preoperative erectile dysfunction (ED; odds ratio: 2.16; 95% confidence interval: 1.03-4.37). In conclusion, preoperative EF represents the only determinant of the use of a higher number of PDE5-Is after surgery. Patients with better preoperative EF might represent individuals more motivated to achieve satisfactory sexual function after surgery. These observations should provide physicians with better preoperative patient counseling and management of postoperative ED.
journal_name
Int J Impot Resjournal_title
International journal of impotence researchauthors
Gandaglia G,Gallina A,Suardi N,Abdollah F,Passoni N,Bianchi M,Zaffuto E,Nini A,Vizziello D,Salonia A,Montorsi F,Briganti Adoi
10.1038/ijir.2014.10subject
Has Abstractpub_date
2014-11-01 00:00:00pages
201-4issue
6eissn
0955-9930issn
1476-5489pii
ijir201410journal_volume
26pub_type
杂志文章abstract：:Premature ejaculation (PE), the most common sexual dysfunctions in men, is characterized by loss or absence of ejaculatory control. PE can be classified as either a lifelong or acquired condition. Although the prevalence of lifelong PE is rather low in the general male population, recent studies demonstrated that the ...
journal_title：International journal of impotence research
pub_type： 杂志文章,评审
doi：10.1038/ijir.2012.12
更新日期：2012-09-01 00:00:00
abstract：:This workshop completes the trilogy of nuances of the various incisions used to place an inflatable penile prosthesis (IPP). Infrapubic placement was the original technique employed 50 years ago for the very first IPP surgeries. The historical perspective of the development of implantation incisions and the original S...
journal_title：International journal of impotence research
pub_type： 杂志文章,评审
doi：10.1038/s41443-020-00370-y
更新日期：2020-12-18 00:00:00
abstract：:Although decline in sexual function is a common reason for ageing men to seek advice regarding testosterone therapy, placebo-controlled trial data have been unable to show a consistent, beneficial role for testosterone. The objective of this study was to determine the effect of testosterone therapy on sexual function ...
journal_title：International journal of impotence research
pub_type： 杂志文章,随机对照试验
doi：10.1038/ijir.2008.22
更新日期：2008-07-01 00:00:00
abstract：:Sildenafil citrate, marketed as Viagra, for the treatment of erectile dysfunction, has a proven record of safety in humans as predicted by the results of extensive pharmacological and toxicological testing in animals and in vitro, and confirmed by pharmacokinetic exposure data. The aim of this paper is to review succi...
journal_title：International journal of impotence research
pub_type： 杂志文章,评审
doi：10.1038/sj.ijir.3901232
更新日期：2004-12-01 00:00:00
abstract：:This study examined the effects of a new phosphodiesterase type 5 inhibitor, DA-8159, on erectile function associated with hypercholesterolemia. First of all, in order to investigate whether chronic administration of DA-8159 prevents the development of erectile dysfunction associated with hypercholesterolemia, male SD...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3901331
更新日期：2005-09-01 00:00:00
abstract：:Cross-linked dextran and polymethylmethacrylate mixture (Lipen-10) is newly developed tissue filler. The purpose of this study was to evaluate tolerability and efficacy of Lipen-10 on penile enhancement. Twenty adult males were included in this study. Lipen-10 was injected into the subcutaneous tissue of the penile sh...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/ijir.2012.41
更新日期：2013-05-01 00:00:00
abstract：:Although several studies on toxic effect of aspartame metabolite have been studied, controversial reports over the use of aspartame owing to the fact that it releases methanol as one of its metabolite during metabolism exist. This present study is proposed to investigate whether aspartame (40 mg kg-1 b.wt) administrat...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/ijir.2017.17
更新日期：2017-07-01 00:00:00
abstract：:The aim of the present study was to investigate which PD specific factors (e.g., degree of penile curvature, levels of pain) cause most distress and to further explore whether there are specific subgroups of patients that report particularly high levels of psychological distress. Data were available for N = 119 men wi...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/s41443-018-0029-3
更新日期：2018-08-01 00:00:00
abstract：:Dissection of the pudendal nerve (PN) and its branches in 71 cadavers revealed anatomic variations not previously described. Knowledge of this variation is necessary to prevent nerve injury resulting in sexual of sensory dysfunction. Because descriptions vary, this study re-evaluated the anatomy of the PN as implicate...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/ijir.2015.10
更新日期：2015-07-01 00:00:00
abstract：:Using our prospectively derived database, we identified 17 patients with squamous-cell carcinoma involving the glans penis, who were treated using organ-sparing surgery between March 2003 and January 2008. Of them, two were treated with partial glansectomy with primary glans closure, and 15 underwent total glans amput...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/ijir.2009.17
更新日期：2009-09-01 00:00:00
abstract：:Nitric oxide (NO) is a physiologic signal essential to penile erection, and disorders that reduce NO synthesis or release in the erectile tissue are commonly associated with erectile dysfunction. NO synthase (NOS) catalyzes production of NO from L-arginine. While both constitutively expressed neuronal NOS (nNOS) and e...
journal_title：International journal of impotence research
pub_type： 杂志文章,评审
doi：10.1038/sj.ijir.3901209
更新日期：2004-06-01 00:00:00
abstract：:Several analyses have demonstrated a clinically useful relationship between serum prostate specific antigen (PSA) and prostate volume in men with benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Both prostate volume and serum PSA predict certain aspects of the natural history of LUTS and BPH...
journal_title：International journal of impotence research
pub_type： 杂志文章,评审
doi：10.1038/ijir.2008.53
更新日期：2008-12-01 00:00:00
abstract：:We describe a case of gunshot wound to the corpora cavernosa caused by a low-velocity bullet in a 43-year-old man. He volunteered that his lover's husband shot him with a handgun. The bullet had penetrated the right gluteal region with no exit wound causing a right corpus cavernosum lesion. A penile colour-duplex dopp...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3901472
更新日期：2006-11-01 00:00:00
abstract：:The aim of this study was to report feasibility, benefit and complications of superselective transcatheter autologous clot embolizations and duplex sonography-guided compression therapy in four patients with delayed post-traumatic high-flow priapism. Medical records of four consecutive patients diagnosed with delayed ...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3901373
更新日期：2006-03-01 00:00:00
abstract：AIMS OF THIS STUDY:This study evaluated whether human cavernosal myofibroblasts in cell culture is a viable model for the study of the role of oxygen free radicals in the production of collagen types I and III, as observed in Peyronie's disease. METHOD:Human cavernosal cells in primary culture were incubated with 3H-p...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3900414
更新日期：1999-08-01 00:00:00
abstract：:Considering the presence of dopaminergic receptors in the lumbosacral spinal cord, we tested whether apomorphine could exert a proerectile effect by acting at the spinal level. Intracavernous (ICP) and blood pressures (BP) were measured in anesthetized rats. ICP rises were quantified (duration, percentage of ICPmaximu...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3900654
更新日期：2001-04-01 00:00:00
abstract：:The first goal of this study was to examine the effect of secondhand smoking on neurogenic, endothelium- and cGMP-dependent relaxant responses of rabbit corpus cavernosum smooth muscle. Our second goal was to determine whether such an effect can be prevented by oral administration of L-arginine. Male New Zealand rabbi...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3901341
更新日期：2005-09-01 00:00:00
abstract：:Erectile dysfunction occurs frequently in humans with diabetes mellitus; the molecular basis of this phenomenon is not known. We investigated the effects of diabetes on penile erection, nitric oxide synthase and growth factors expression in an animal model. Forty male rats were divided into two groups: the experimenta...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3900392
更新日期：1999-06-01 00:00:00
abstract：:The majority of medical students and medical healthcare providers do not feel comfortable when addressing sexual problems. It was suggested that more courses in sexual health are needed at medical schools to overcome this shortcoming. To assess medical students' interest in and attitude about sexual health education a...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/ijir.2016.25
更新日期：2016-09-01 00:00:00
abstract：:End-stage renal disease (ESRD) affects sexual function. The etiology of sexual dysfunction in ESRD is multifactorial and hypogonadism is not uncommon. In a cohort of 96 men with ESRD, scores on International Index of Erectile Function (IIEF) correlated with bioavailable testosterone (T; P<0.01). We further evaluated t...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/ijir.2009.55
更新日期：2010-03-01 00:00:00
abstract：:The present study provides a review of stem cell therapy as a treatment of erectile dysfunction from peer-reviewed human and animal trials. A literature search was conducted in PubMed-Medline, Scopus, Embase, and Cochrane databases. Tweenty-three animal studies and seven human studies in the period from 1st of January...
journal_title：International journal of impotence research
pub_type： 杂志文章,评审
doi：10.1038/s41443-020-00406-3
更新日期：2021-01-15 00:00:00
abstract：:In erectile dysfunction (ED) research, monocultures of cavernous endothelial cells (CECs) and smooth muscle cells (CSMCs) have been reported, but a CEC-CSMC coculture system is still lacking. In the present study, we wished to investigate the feasibility of setting up such a system and test whether it can be used for ...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/ijir.2012.36
更新日期：2013-03-01 00:00:00
abstract：:Erectile dysfunction (ED) is the consistent inability to achieve and maintain an erection sufficient for satisfactory sexual activity. Erectile dysfunction affects as many as 30 million men in America, with an increasing prevalence with age. Erectile dysfunction is secondary to organic, psychogenic and combined causes...
journal_title：International journal of impotence research
pub_type： 杂志文章,评审
doi：10.1038/sj.ijir.3901477
更新日期：2007-01-01 00:00:00
abstract：:Experimental models to study the effect of agents on penile erection usually include electrical stimulation of peripheral nerves in anesthetized animals combined with systemic or intracavernous injection of drugs. The objective of this study was to demonstrate that conscious rabbits can be used as a simple and quantit...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3900703
更新日期：2001-08-01 00:00:00
abstract：:The sexuality and the management of benign prostatic hyperplasia (BPH) with alfuzosin (SAMBA) trial evaluated the effect of alfuzosin on sexual function in men treated for BPH using two sexual function scales: male sexual health questionnaire (MSHQ) and international index of erectile function (IIEF-15). A total of 14...
journal_title：International journal of impotence research
pub_type： 临床试验,杂志文章
doi：10.1038/ijir.2008.62
更新日期：2009-01-01 00:00:00
abstract：:Both RigiScan and the Snap Gauge band devices are used to objectively measure penile rigidity. The Snap Gauge band is the more simple and inexpensive of the two techniques. We investigated the correlation between the results obtained by both devices in order to evaluate whether the Snap Gauge band could be employed as...
journal_title：International journal of impotence research
pub_type： 临床试验,杂志文章
doi：10.1038/sj.ijir.3900438
更新日期：1999-12-01 00:00:00
abstract：:The human T-lymphotropic virus type I (HTLV-I) is a retrovirus associated with a chronic myelopathy known as HTLV-I-Associated Myelopathy or Tropical Spastic Paraparesis (HAM/TSP). The main objective was to assess the frequency of erectile dysfunction (ED) in HTLV-I-infected individuals from Salvador and other cities ...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3901335
更新日期：2005-07-01 00:00:00
abstract：:At this present time there is a serious gap in our understanding of how psychological difficulties result in specific sexual dysfunction. In this paper, a theoretical model of sexual response is proposed which involves the parallel existence of excitatory and inhibitory mechanisms in the central nervous system. Eviden...
journal_title：International journal of impotence research
pub_type： 杂志文章,评审
doi：
更新日期：1998-05-01 00:00:00
abstract：:Sexual dysfunction is a common problem of increasing incidence that is associated with multiple co-morbid conditions and chronic diseases. In heart failure, however, exact numbers are unknown, in part secondary to under-reporting and under-interrogating by health care providers. A gender-specific questionnaire was mod...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3901613
更新日期：2008-01-01 00:00:00
abstract：:Erectile dysfunction (ED), generally associated with reduced sexual desire and sometimes with orgasmic or ejaculatory dysfunction, is the major revealing symptom of hyperprolactinemia (HPRL) in men, a condition that should not be neglected since many cases result from pituitary tumors, likely to result in serious comp...
journal_title：International journal of impotence research
pub_type： 杂志文章,评审
doi：10.1038/sj.ijir.3901043
更新日期：2003-10-01 00:00:00
