Abstract：
:Erectile dysfunction occurs frequently in humans with diabetes mellitus; the molecular basis of this phenomenon is not known. We investigated the effects of diabetes on penile erection, nitric oxide synthase and growth factors expression in an animal model. Forty male rats were divided into two groups: the experimental group (n = 30) received intraperitoneal injection of Streptozotocin (STZ) dissolved in citrate buffer to induce diabetes; ten age-matched control rats received injection of citrate buffer vehicle only. Before euthanization at eight weeks, erectile function was assessed by electrostimulation of the cavernous nerves. NADPH diaphorase staining was used to identify NOS and immunostaining technique was used to identify nNOS in the penile nerve fibers. RT-PCR was used to identify mRNA expression of nNOS, eNOS, iNOS, ER-beta, ER-alpha, NGF, IGF-I, TGF-beta 1, and AR. Western blot was used to identify nNOS, IGF-I, NGF, and TFG-beta protein expressions. In the diabetic group, there was: (1) a significant decrease in NOS containing nerve fibers in the dorsal and intracavernosal nerves; (2) a significant lower maximal intracavernosal pressure. RT-PCR showed down-regulation of nNOS (large form), iNOS and ER-beta mRNA expression, Immunoblot showed down-regulation of nNOS protein expression and nNOS immunostaining showed less positive staining in the dorsal and intracavernous nerves in the diabetic group. These molecular changes may provide the basis for further studies to explore the association between diabetes and impotence.
journal_name
Int J Impot Resjournal_title
International journal of impotence researchauthors
El-Sakka AI,Lin CS,Chui RM,Dahiya R,Lue TFdoi
10.1038/sj.ijir.3900392subject
Has Abstractpub_date
1999-06-01 00:00:00pages
123-32issue
3eissn
0955-9930issn
1476-5489journal_volume
11pub_type
杂志文章abstract：:Even with the help of modern pharmacology, treatment of erectile dysfunction often remains complex, and requires taking into account the social, psychological, and behavioral dimensions of the disorder. This brief report presents a case study highlighting this complexity. ...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3901322
更新日期：2005-07-01 00:00:00
abstract：:This cohort study aimed to assess the effect of the mode of delivery on female sexual function (FSF) after childbirth. Out of 256 primiparous women, 200 subjects that completed the study were divided into two groups; women that delivered vaginally and women that had elective cesarean section (CS). They were subjected ...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/ijir.2015.2
更新日期：2015-05-01 00:00:00
abstract：:Both overweight and obesity have been identified as risk factors for sexual dysfunction in men, but the relationship between sexual function and amount of body fat in females is still obscure. There are few reported studies in women assessing the relationship between female sexual function index (FSFI) and body weight...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/ijir.2010.7
更新日期：2010-07-01 00:00:00
abstract：:Hypercholesterolemia is a major risk factor for erectile dysfunction. To understand the mechanism(s) of hypercholesterolemia-induced erectile dysfunction, we studied the effect of lysophosphatidylcholine (LPC) on the membrane conductance of corporal smooth muscle cells. We used cultured human corporal smooth muscle ce...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3901356
更新日期：2005-11-01 00:00:00
abstract：:In a study on the diagnosis and treatment of erectile dysfunction (ED) in general practice, a self-selected sample of 90 general practitioners (GPs) (76 males, 14 females) from a predominantly urban population of 525 GPs were interviewed. It appeared that 59% would not actively interrogate a patient when an erection p...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：:The single most important factor in the reduction of penile implant infections has been the infection retardant coatings. Virtually every inflatable penile prosthesis (IPP) sold for the last 15 years in America has been coated and the device infection rate has dropped over 50% to less than 1% in experienced implanter ...
journal_title：International journal of impotence research
pub_type： 杂志文章,评审
doi：10.1038/s41443-020-0338-1
更新日期：2020-08-07 00:00:00
abstract：:Non-surgical treatment of Peyronie's disease (PD) has come a long way since it was first described in 1743. A myriad of treatment options are currently available, including oral, intralesional and external energy therapies. The purpose of this article is to review the contemporary literature on non-surgical therapies ...
journal_title：International journal of impotence research
pub_type： 杂志文章,评审
doi：10.1038/ijir.2011.45
更新日期：2012-01-01 00:00:00
abstract：:This randomized controlled cross-over study aimed to assess the efficacy and safety of glans penis injection with hyaluronic acid (HA) in treating premature ejaculation (PE). A total of 30 patients with PE were randomly allocated into two groups: group 1 (n = 15) which was subjected to glans penis HA injection and gro...
journal_title：International journal of impotence research
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41443-018-0104-9
更新日期：2019-09-01 00:00:00
abstract：:We sought to establish the interplay of metabolic syndrome (MetS) and/or sexual dysfunction (SD) on hypogonadism. Sexual functioning was assessed using Golombok Rust Inventory of Sexual Satisfaction in 274 consecutive diabetic men visiting the diabetic clinic of the Tema General Hospital between November 2010 and Marc...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/ijir.2017.6
更新日期：2017-05-01 00:00:00
abstract：:Coronavirus disease 2019 (COVID-19) pandemic has been continuing to affect the lives of all people globally. It has been shown that restrictions due to changes in lifestyles lead to mental health problems. This study aims to investigate the effect of COVID-19 pandemic on couples' sexuality. A total of 245 volunteers (...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/s41443-020-00378-4
更新日期：2020-12-16 00:00:00
abstract：:Tunica albuginea (TA) of the penis, which has an important role in mechanism of erection, is composed mainly of collagen bundles. Both aging and diabetes mellitus (DM) were reported to be associated with many alterations in collagen content and architecture in several body tissues. So, the aim of this work was to eval...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3900389
更新日期：1999-04-01 00:00:00
abstract：:Hard flaccid (HF) is a group of symptoms that significantly affects a man's sexual and social life. As this syndrome has only been reported in several patient forums, exact prevalence of this rare condition is unknown. Currently, no scientific literature exists of the syndrome. We, hereby, aimed to present four cases ...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/s41443-019-0133-z
更新日期：2020-03-01 00:00:00
abstract：:Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by parkinsonism and cerebellar, autonomic, urinary, and/or pyramidal dysfunction. Urinary and erectile dysfunction (ED) symptoms are prominent early features in men with MSA. Autonomic failure, considered until recently to be the ca...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3901014
更新日期：2003-08-01 00:00:00
abstract：:The effects of hypoxia (pO2: 50 mmHg), acidosis (pH: 6.9) or glucopenia (absence of glucose) in vitro on the tone of the rabbit corpus cavernosum were investigated. The recovery of smooth muscle contractility following exposure to these conditions was also assessed. Hypoxia, acidosis or glucopenia alone or in combinat...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3901231
更新日期：2005-01-01 00:00:00
abstract：:Soluble guanylyl cyclase (sGC) is the major effector molecule for nitric oxide (NO) and as such an interesting therapeutic target for the treatment of erectile dysfunction. To assess the functional importance of the sGCalpha(1)beta(1) isoform in corpus cavernosum (CC) relaxation, CC from male sGCalpha(1)(-/-) and wild...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3901627
更新日期：2008-05-01 00:00:00
abstract：:The aim of this study is to review the current literature that reports outcomes of Peyronie's disease (PD) grafting surgery, with a special focus on novel approaches and grafting materials. For this purpose, a literature review was performed through PubMed between 2014 and 2019 regarding grafting techniques in PD reco...
journal_title：International journal of impotence research
pub_type： 杂志文章,评审
doi：10.1038/s41443-019-0179-y
更新日期：2020-01-01 00:00:00
abstract：:The sympathetic nervous system is important for penile function: it mediates detumescence and may contribute to the maintenance of the penis in a non-erect state. The sympathetic preganglionic neurons are found in the intermediolateral gray matter of the spinal cord. Postganglionic neurons are located to the sympathet...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：:In a prospective, placebo-controlled, one group crossover design study, we tested whether adding programmed intracavernous PGE1 injections (IC-PGE1) can improve the effectiveness of sildenafil in erectile dysfunction (ED) patients unresponsive to monotherapy with this drug. In all, 40 ED patients who had experienced u...
journal_title：International journal of impotence research
pub_type： 临床试验,杂志文章
doi：10.1038/sj.ijir.3901290
更新日期：2005-07-01 00:00:00
abstract：:Phosphodiesterase 5 (PDE5) inhibitors are efficacious in treating patients with erectile dysfunction. New PDE5 inhibitors with different selectivity and pharmacokinetic profiles have been vigorously pursued. Here we report two novel, potent, and selective PDE5 inhibitors, JNJ-10280205 and JNJ-10287069, with Ki values ...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3901462
更新日期：2006-09-01 00:00:00
abstract：:In extracavernosal vascular tissue, smooth muscle tone is modulated by a balance between angiotensin II (Ang II) and nitric oxide (NO). We hypothesized that these substances also play an important role in regulating cavernosal smooth muscle contractility. We therefore studied the in vitro effects of an Ang II receptor...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3900261
更新日期：1997-09-01 00:00:00
abstract：:There is strong evidence from multiple epidemological studies that lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) are correlated, independent of age or comorbidities as diabetes or hypertension. Although a direct causal relationship is not established yet, four pathophysiological mechanisms can expl...
journal_title：International journal of impotence research
pub_type： 杂志文章,评审
doi：10.1038/ijir.2011.14
更新日期：2011-05-01 00:00:00
abstract：:The objective of this study is to investigate whether the L-arginine/nitric oxide pathway is involved in the neurotransmission of paraventricular nucleus of hypothalamus (PVN) activation-induced penile erection in the rat. Male adult Sprague-Dawley rats anesthetized with pentobarbital were used. The femoral artery was...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3900825
更新日期：2002-06-01 00:00:00
abstract：:Erectile dysfunction (ED) is linked to various cardiovascular risk factors and may therefore serve as a predictor of cardiovascular events. To gain further insight into this relationship, we reviewed all data regarding hospital admission for cardial or cerebral vascular disease that occurred until 2008 in a cohort of ...
journal_title：International journal of impotence research
pub_type： 杂志文章,随机对照试验
doi：10.1038/ijir.2009.40
更新日期：2010-01-01 00:00:00
abstract：:This work aimed to assess the cavernous anti-apoptotic role of using chronic low-dose sildenafil/tadalafil with and without testosterone (T) in aged diabetic rats. In all, 140 Sprague-Dawley aged rats were divided into the following groups: controls; induced diabetic rats; diabetic rats that received intramuscular dep...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/ijir.2010.12
更新日期：2010-07-01 00:00:00
abstract：:The first goal of this study was to examine the effect of secondhand smoking on neurogenic, endothelium- and cGMP-dependent relaxant responses of rabbit corpus cavernosum smooth muscle. Our second goal was to determine whether such an effect can be prevented by oral administration of L-arginine. Male New Zealand rabbi...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3901341
更新日期：2005-09-01 00:00:00
abstract：:This study was conducted to determine rate and related factors of dyspareunia. Three hundred and nineteen women aged 15-49 years were surveyed. A questionnaire was used to collect data. Pelvic examinations and connective tissue disorders were investigated. At whole 54.5% had dyspareunia. The means of gravidity, parity...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3901495
更新日期：2007-01-01 00:00:00
abstract：:This discussion summarizes the potential differences in physiologically and pharmacologically induced erections and highlights the possible differences in the pathways facilitated by oral versus intracavernosal agents in penile erection. Oral agents act in conjunction with sexual stimulation either increasing corporal...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：:Defining the minimal clinically meaningful improvement (MCMI) is crucial to understanding the treatment effects on health-status measures. We estimated the MCMI on the quality of erection questionnaire (QEQ), a validated measure specific to assess erectile quality during sexual intercourse. Data were from two controll...
journal_title：International journal of impotence research
pub_type： 杂志文章,随机对照试验
doi：10.1038/ijir.2009.47
更新日期：2010-01-01 00:00:00
abstract：:Penile intra-epithelial neoplasia (PeIN) is a known precursor for penile cancer. It may be undifferentiated or differentiated. The former is related to high-risk Human Papilloma Virus (HPV) and associated with p16 over-expression. Patients may present with red patches or lesions on the penis which on occasion may affe...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/s41443-020-0327-4
更新日期：2020-07-24 00:00:00
abstract：:Although several studies on toxic effect of aspartame metabolite have been studied, controversial reports over the use of aspartame owing to the fact that it releases methanol as one of its metabolite during metabolism exist. This present study is proposed to investigate whether aspartame (40 mg kg-1 b.wt) administrat...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/ijir.2017.17
更新日期：2017-07-01 00:00:00
