Abstract:
:The objective of this study is to investigate whether the L-arginine/nitric oxide pathway is involved in the neurotransmission of paraventricular nucleus of hypothalamus (PVN) activation-induced penile erection in the rat. Male adult Sprague-Dawley rats anesthetized with pentobarbital were used. The femoral artery was cannulated to measure systemic and mean arterial pressure (SAP and MAP), and heart rate (HR). A 26-gauge needle was inserted into corpus cavernosum to measure the intracavernous pressure (ICP) simultaneously with SAP, MAP and HR on a polygraph. Four groups of study were arranged: (1) stereotaxically delivery of L-arginine (500 nmol/500 nl) into PVN; (2) administration of a mixture (1 microl) containing N(G)-Nitro-L-arginine methyl ester (L-NAME) 500 nmol and L-arginine 500 nmol into PVN; (3) microinjection of saline 500 nl into PVN as a vehicle control; and (4) intracavernous injection of L-arginine (100 nmol/50 microl). The ICP, SAP, MAP and HR were monitored for at least 2 h after each administration of the experimental agents. Upon administration of L-arginine into PVN, there was a significant increase of ICP from resting 9.6+/-2.5 mmHg to peaked at 64.4+/-9.8 mmHg after a latency of 3016.0+/-1749.7 s and with a duration of 27.6+/-15.8 min. There was no change of resting ICP after administration of the mixture of L-NAME and L-arginine into PVN. Application of saline to PVN and intracavernous injection of L-arginine failed to increase ICP. Based on elicitation of penile erection upon administration of L-arginine into PVN, and elimination of this L-arginine induced penile erection by co-administration of L-NAME with L-arginine, the results of this study suggest that L-arginine/nitric oxide pathway may be involved in the neurotransmission of PVN activation-induced penile erection in the rat.
journal_name
Int J Impot Resjournal_title
International journal of impotence researchauthors
Chen KK,Chang LSdoi
10.1038/sj.ijir.3900825subject
Has Abstractpub_date
2002-06-01 00:00:00pages
139-45issue
3eissn
0955-9930issn
1476-5489journal_volume
14pub_type
杂志文章abstract::Experimental models to study the effect of agents on penile erection usually include electrical stimulation of peripheral nerves in anesthetized animals combined with systemic or intracavernous injection of drugs. The objective of this study was to demonstrate that conscious rabbits can be used as a simple and quantit...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900703
更新日期:2001-08-01 00:00:00
abstract::The aim of this study is to review the current literature that reports outcomes of Peyronie's disease (PD) grafting surgery, with a special focus on novel approaches and grafting materials. For this purpose, a literature review was performed through PubMed between 2014 and 2019 regarding grafting techniques in PD reco...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/s41443-019-0179-y
更新日期:2020-01-01 00:00:00
abstract::Peyronie's disease is a localized connective tissue disorder, caused by trauma to the erect penis, which results in cellular proliferation and excess extracellular matrix production within the tunica albuginea of the penis. We have previously demonstrated that cells derived from Peyronie's disease plaque tissue demons...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901183
更新日期:2004-04-01 00:00:00
abstract::The sympathetic nervous system is important for penile function: it mediates detumescence and may contribute to the maintenance of the penis in a non-erect state. The sympathetic preganglionic neurons are found in the intermediolateral gray matter of the spinal cord. Postganglionic neurons are located to the sympathet...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract::We evaluated spontaneous tumescence after penile prostheses implantation in a retrospective study. A total of 32 patients with three-piece hydraulic implants (17 Mentor Alpha I, 15 AMS Ultrex Plus) were enrolled. Consultation, personal interviews and questionnaires for both the patients and their partners provided the...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900979
更新日期:2003-06-01 00:00:00
abstract::The objective was to investigate the cellular effect and action mechanism of Artemisia capillaris extract (ACE) and its component, scopoletin, on penile corpus cavernosum smooth muscle (PCCSM). In vitro study with PCCSM, the precontracted PCCSM with phenylephrine was treated with ACE or scopoletin. Cyclic nucleotides ...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2015.23
更新日期:2015-11-01 00:00:00
abstract::We have investigated the reliability of intracavernosal prostaglandin E1 (PGE1) office vs self-injection therapy in patients with erectile dysfunction (ED). A total of 298 male patients with ED were enrolled in this study. In all patients, intracavernosal titration of the PGE1 dose was performed. A total of 106 patien...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901388
更新日期:2006-03-01 00:00:00
abstract::During penile pharmacotesting, anxiety may overcome complete smooth muscle relaxation and lead to false positive diagnosis of organic male erectile dysfunction (ED). We tested the efficacy and safety of re-dosing of PGE1 alone versus combination of PGE, and the alpha1,2-blocker phentolamine (PHE) to improve an incompl...
journal_title:International journal of impotence research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ijir.3900477
更新日期:2000-02-01 00:00:00
abstract::The transient receptor potential cationic channel type A1 (TRPA1), belonging to a superfamily of cationic membrane channels, has been suggested to act as mechano- and pain sensor and, thus, to play a role in neurotransmission in the human body, including the urogenital tract. While the expression of TRPA1 has been inv...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2014.23
更新日期:2015-01-01 00:00:00
abstract::Sildenafil citrate has been shown to be effective in a wide range of patients with erectile dysfunction and has been approved in the United States for this indication. The overall clinical safety of oral sildenafil, a potent inhibitor of phosphodiesterase type 5, in the treatment of erectile dysfunction was evaluated ...
journal_title:International journal of impotence research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ijir.3900354
更新日期:1998-06-01 00:00:00
abstract::Sildenafil citrate, marketed as Viagra, for the treatment of erectile dysfunction, has a proven record of safety in humans as predicted by the results of extensive pharmacological and toxicological testing in animals and in vitro, and confirmed by pharmacokinetic exposure data. The aim of this paper is to review succi...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/sj.ijir.3901232
更新日期:2004-12-01 00:00:00
abstract::A total of 76 male patients on renal replacement therapy (RRT) were investigated. Erectile dysfunction (ED) was defined as insufficient erection during visual erotic stimulation (VES) or during sleep as measured with Rigiscan and Erectiometer. Data on medical history, physical examination, and laboratory variables wer...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900946
更新日期:2003-02-01 00:00:00
abstract::A lack of uniformity exists for insurance payer coverage for all categories of penile prostheses (PP). We sought to determine common insurance coverage criteria and barriers to implantation across common insurance plans from healthcare referral regions (HRR) nationwide. Coverage criteria and stipulations were reviewed...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/s41443-019-0226-8
更新日期:2021-01-01 00:00:00
abstract::The objective was to describe funding sources and publication trends for the primary literature on Peyronie's disease (PD), including direct industry research support. A search of EMBASE, PubMed, Scopus, and Web of Science was performed to identify articles published from 2006 to 2018. Articles not published in Englis...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/s41443-020-0244-6
更新日期:2021-01-01 00:00:00
abstract::This prospective study determined the rate of abandonment of sildenafil therapy and assessed the reasons for abandonment. Between January 2001 and December 2002, 234 patients with erectile dysfunction (ED) at three independent centers successfully began therapy with sildenafil 50 or 100 mg. The rate of noncompliance w...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901252
更新日期:2005-01-01 00:00:00
abstract::Nitric oxide (NO) is a physiologic signal essential to penile erection, and disorders that reduce NO synthesis or release in the erectile tissue are commonly associated with erectile dysfunction. NO synthase (NOS) catalyzes production of NO from L-arginine. While both constitutively expressed neuronal NOS (nNOS) and e...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/sj.ijir.3901209
更新日期:2004-06-01 00:00:00
abstract::Erectile dysfunction (ED) develops owing to psychogenic, organic or/and both of these two factors. The aim of this study was to investigate the relationship between penile cavernosal arterial flow and peripheral atherosclerosis in men with ED. This study was conducted on 102 patients who had presented to Radiology Cli...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2013.35
更新日期:2014-03-01 00:00:00
abstract::Between December 1996 and December 1998, 79 inflatable penile implant insertions have been performed at our institution by a single surgeon. The objective of this analysis was to compare our in-patient and out-patient experience with penile prosthesis insertion with respect to ease of performance and complication prof...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900695
更新日期:2001-10-01 00:00:00
abstract::The first goal of this study was to examine the effect of secondhand smoking on neurogenic, endothelium- and cGMP-dependent relaxant responses of rabbit corpus cavernosum smooth muscle. Our second goal was to determine whether such an effect can be prevented by oral administration of L-arginine. Male New Zealand rabbi...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901341
更新日期:2005-09-01 00:00:00
abstract::To date, no effective medical approach for the treatment of erectile dysfunction (ED) secondary to ischemic priapism (IP) has been described. The aim of this study was to evaluate the anti-inflammatory, antifibrotic, and antioxidant effects of pirfenidone (PFD) on cavernosal tissue in a rat model of IP. Forty-eight ma...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/s41443-019-0152-9
更新日期:2020-03-01 00:00:00
abstract::A prospective study was done on 76 patients who underwent surgical correction by corporeal plication of the penile deformity secondary to Peyronie's disease. Nocturnal penile tumescence and rigidity were recorded by RigiScan during three consecutive nights, before and after the operation. A significant number of patie...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract::Psoriasis is a chronic inflammatory skin disease and seems to be associated with erectile dysfunction (ED). ED is a predictor of future cardiovascular disease. It is important to identify ED early and investigate cardiovascular problems in psoriasis patients. The sample consisted of 191 psoriasis patients and 191 heal...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2016.6
更新日期:2016-05-01 00:00:00
abstract::Gynecomastia is an unusual side effect associated with testosterone replacement therapy (TRT) that has been traditionally treated with surgery, radiation, or discontinuation of testosterone supplementation. We report here our experience with two cases of gynecomastia in men undergoing TRT who were successfully treated...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901154
更新日期:2004-02-01 00:00:00
abstract::The objective of this study was to investigate the predictive validity of the Dutch translation of the Golombok Rust Inventory of Sexual Satisfaction (GRISS) for the presence of clinically relevant sexual dysfunctions and patient's need of help. A total of 57 male urological outpatients (age 50.7+/-13.2 y; range 27-77...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900966
更新日期:2003-04-01 00:00:00
abstract::Cross-linked dextran and polymethylmethacrylate mixture (Lipen-10) is newly developed tissue filler. The purpose of this study was to evaluate tolerability and efficacy of Lipen-10 on penile enhancement. Twenty adult males were included in this study. Lipen-10 was injected into the subcutaneous tissue of the penile sh...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2012.41
更新日期:2013-05-01 00:00:00
abstract::Phosphodiesterase 5 (PDE5) inhibitors are efficacious in treating patients with erectile dysfunction. New PDE5 inhibitors with different selectivity and pharmacokinetic profiles have been vigorously pursued. Here we report two novel, potent, and selective PDE5 inhibitors, JNJ-10280205 and JNJ-10287069, with Ki values ...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901462
更新日期:2006-09-01 00:00:00
abstract::Erectile dysfunction (ED) is linked to various cardiovascular risk factors and may therefore serve as a predictor of cardiovascular events. To gain further insight into this relationship, we reviewed all data regarding hospital admission for cardial or cerebral vascular disease that occurred until 2008 in a cohort of ...
journal_title:International journal of impotence research
pub_type: 杂志文章,随机对照试验
doi:10.1038/ijir.2009.40
更新日期:2010-01-01 00:00:00
abstract::The diagnosis and classification of female sexual disorders has undergone significant changes over the last fifty years as a function of changing societal expectations for female sexual conduct, available knowledge about sexual psychophysiology and actual clinical practice. Currently, female sexual disorders are conce...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1201/b14618-47
更新日期:1998-05-01 00:00:00
abstract::Erectile dysfunction is a common disorder. However, not all dysfunctional men want to pursue evaluation. To delineate the characteristics of men interested in evaluation of erectile dysfunction, we conducted a mailed survey of 1031 randomly selected male veterans aged 30-99 years. We received 427 completed surveys. Us...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::In March 2020, the Italian Government introduced measures to reduce the spread of COVID-19 infection. Between 8th April and 2nd May 2020 we investigated levels and correlates of sexual activity and depression during COVID-19 lockdown in a sample of hospital workers and their acquaintances by an online survey on Survey...
journal_title:International journal of impotence research
pub_type: 信件
doi:10.1038/s41443-020-00393-5
更新日期:2021-01-01 00:00:00