Limited acute influences of electrical baroreceptor activation on insulin sensitivity and glucose delivery: a randomized, double-blind, crossover clinical study.


:Arterial baroreflexes may regulate resistance vessels supplying glucose to skeletal muscle by modulating efferent sympathetic nervous system activity. We hypothesized that selective manipulation of baroreflex activity through electrical carotid sinus stimulation influences insulin sensitivity by changing muscular glucose delivery. We enrolled 16 hypertensive patients who responded to treatment with an electrical carotid sinus stimulator. Patients were submitted to a frequently sampled intravenous glucose tolerance test (FSIGT) with the stimulator on and with the stimulator off on separate days in a randomized, double-blind, crossover study. We monitored interstitial glucose, lactate, and pyruvate in the vastus lateralis muscle using microdialysis. Glucose and insulin concentrations in arterialized venous blood before and during FSIGT were virtually identical with the stimulator on and with the stimulator off. Insulin sensitivity, the primary end point of this study, was 3.3 ± 1.0 (mU/L)(-1) ⋅ min(-1) and 4.4 ± 2.6 (mU/L)(-1) ⋅ min(-1) (on vs. off; P = 0.7). Interstitial glucose, lactate, and pyruvate increased similarly during FSIGT regardless of the stimulator settings. In conclusion, acute changes in baroreceptor stimulation did not elicit significant changes in muscular glucose delivery and whole-body insulin sensitivity. Baroreflex-mediated changes in sympathetic vasomotor tone may have a limited acute effect on muscle glucose metabolism in patients with treatment-resistant hypertension.






May M,Ahrens J,Menne J,Haller H,Beige J,Eckert S,Jordan J,Engeli S




Has Abstract


2014-08-01 00:00:00
















  • Negative Regulation of TRPA1 by AMPK in Primary Sensory Neurons as a Potential Mechanism of Painful Diabetic Neuropathy.

    abstract::AMPK is a widely expressed intracellular energy sensor that monitors and modulates energy expenditure. Transient receptor potential ankyrin 1 (TRPA1) channel is a widely recognized chemical and thermal sensor that plays vital roles in pain transduction. In this study, we discovered a functional link between AMPK and T...


    pub_type: 杂志文章


    authors: Wang S,Kobayashi K,Kogure Y,Yamanaka H,Yamamoto S,Yagi H,Noguchi K,Dai Y

    更新日期:2018-01-01 00:00:00

  • Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance.

    abstract::Obesity and dysfunctional energy partitioning can lead to the development of insulin resistance and type 2 diabetes. The antidiabetic thiazolidinediones shift the energy balance toward storage, leading to an increase in whole-body adiposity. These studies examine the effects of pioglitazone (Pio) on adipose tissue phy...


    pub_type: 杂志文章


    authors: de Souza CJ,Eckhardt M,Gagen K,Dong M,Chen W,Laurent D,Burkey BF

    更新日期:2001-08-01 00:00:00

  • Gene transfer to human pancreatic endocrine cells using viral vectors.

    abstract::We have studied the factors that influence the efficiency of infection of human fetal and adult pancreatic endocrine cells with adenovirus, murine retrovirus, and lentivirus vectors all expressing the green fluorescent protein (Ad-GFP, MLV-GFP, and Lenti-GFP, respectively). Adenoviral but not retroviral vectors effici...


    pub_type: 杂志文章


    authors: Leibowitz G,Beattie GM,Kafri T,Cirulli V,Lopez AD,Hayek A,Levine F

    更新日期:1999-04-01 00:00:00

  • Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action.

    abstract::In pancreatic beta-cells, glucose metabolism signals insulin secretion by altering the cellular array of messenger molecules. ATP is particularly important, given its role in regulating cation channel activity, exocytosis, and events dependent upon its hydrolysis. Uncoupling protein (UCP)-2 is proposed to catalyze a m...


    pub_type: 杂志文章


    authors: Chan CB,De Leo D,Joseph JW,McQuaid TS,Ha XF,Xu F,Tsushima RG,Pennefather PS,Salapatek AM,Wheeler MB

    更新日期:2001-06-01 00:00:00

  • Gastric inhibitory polypeptide and glucagon-like peptide-1 in the pathogenesis of type 2 diabetes.

    abstract::The incretin effect denominates the phenomenon that oral glucose elicits a higher insulin response than does intravenous glucose. The two hormones responsible for the incretin effect, glucose-dependent insulinotropic hormone (GIP) and glucagon-like peptide-1 (GLP-1), are secreted after oral glucose loads and augment i...


    pub_type: 杂志文章,评审


    authors: Nauck MA,Baller B,Meier JJ

    更新日期:2004-12-01 00:00:00

  • Progression to type 2 diabetes characterized by moderate then rapid glucose increases.

    abstract:OBJECTIVE:The transition of an individual from normoglycemia to diabetes has generally been thought to involve either moderate or rapid changes in glucose over time, although few studies have analyzed these changes. We sought to determine whether a general pattern of glucose change exists in most individuals who become...


    pub_type: 杂志文章


    authors: Mason CC,Hanson RL,Knowler WC

    更新日期:2007-08-01 00:00:00

  • Leptin resistance during aging is independent of fat mass.

    abstract::Increased fat mass, abdominal adiposity, and insulin resistance are typical findings in aging mammals and are frequently associated with leptin resistance and increased plasma leptin levels. To examine whether leptin's failure in aging is due to aging per se or to changes in body fat mass or distribution, we studied a...


    pub_type: 杂志文章


    authors: Gabriely I,Ma XH,Yang XM,Rossetti L,Barzilai N

    更新日期:2002-04-01 00:00:00

  • Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes.

    abstract::Type 1 diabetes results from chronic autoimmune destruction of insulin-producing β-cells within pancreatic islets. Although insulin is a critical self-antigen in animal models of autoimmune diabetes, due to extremely limited access to pancreas samples, little is known about human antigenic targets for islet-infiltrati...


    pub_type: 杂志文章


    authors: Michels AW,Landry LG,McDaniel KA,Yu L,Campbell-Thompson M,Kwok WW,Jones KL,Gottlieb PA,Kappler JW,Tang Q,Roep BO,Atkinson MA,Mathews CE,Nakayama M

    更新日期:2017-03-01 00:00:00

  • Identification of an interactive effect of beta3- and alpha2b-adrenoceptor gene polymorphisms on fat mass in Caucasian women.

    abstract::Several adrenoceptor subtypes are expressed in adipocytes, which together exert their influence on adipocyte metabolism. Therefore, we specifically examined the interactive effect of Trp64Arg (beta3) and Glu12/Glu9 (alpha2b) adrenoceptor (AR) polymorphisms on energy metabolism and body composition in healthy women wit...


    pub_type: 杂志文章


    authors: Dionne IJ,Turner AN,Tchernof A,Pollin TI,Avrithi D,Gray D,Shuldiner AR,Poehlman ET

    更新日期:2001-01-01 00:00:00

  • Modulation of glucocorticoid-induced GAD expression in pancreatic beta-cells by transcriptional activation of the GAD67 promoter and its possible effect on the development of diabetes.

    abstract::GAD is a pancreatic beta-cell autoantigen in humans and nonobese diabetic (NOD) mice. Modulation of GAD expression in pancreatic beta-cells has been suggested to be associated with the development of autoimmune diabetes. Hormonal changes through environmental stimuli are considered to influence the expression of the d...


    pub_type: 杂志文章


    authors: Kim KS,Kang Y,Choi SE,Kim JH,Kim HM,Sun B,Jun HS,Yoon JW

    更新日期:2002-09-01 00:00:00

  • The influence of diabetes on the vasomotor responses of saphenous vein and the development of infra-inguinal vein graft stenosis.

    abstract::There has been a prejudice that diabetes modulates the function of saphenous vein in a manner that predisposes to bypass graft failure, although most of the evidence accrues from animal studies. We have investigated the effect of diabetes on the vasodilator responses and ultrastructure of saphenous vein harvested from...


    pub_type: 杂志文章


    authors: Hicks RC,Moss J,Higman DJ,Greenhalgh RM,Powell JT

    更新日期:1997-01-01 00:00:00

  • Effect of exogenous phospholipase A2 on insulin secretion from perifused rat islets.

    abstract::Treatment of isolated, perifused rat islets with exogenous PLA2 in amounts ranging from 1 to 1000 mU/ml caused a dose-dependent increase in the rate of insulin secretion. This effect of PLA2 was rapid and seen in the absence of added exogenous fuel. It differed from glucose-induced insulin release in temporal pattern:...


    pub_type: 杂志文章


    authors: Zawalich W,Zawalich K

    更新日期:1985-05-01 00:00:00

  • The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells.

    abstract::The glycolytic enzyme glucokinase plays a primary role in the glucose-responsive secretion of insulin, and defects of this enzyme can cause NIDDM. As a step toward understanding the molecular basis of glucokinase (GK) gene regulation, we assessed the structure and regulation of the human GK gene beta-cell-type promote...


    pub_type: 杂志文章


    authors: Watada H,Kajimoto Y,Umayahara Y,Matsuoka T,Kaneto H,Fujitani Y,Kamada T,Kawamori R,Yamasaki Y

    更新日期:1996-11-01 00:00:00

  • Predictive value of lymphocyte antibodies for the appearance of diabetes in BB rats.

    abstract::Lymphocyte antibodies have been described in autoimmune disorders, including insulin-dependent diabetes mellitus (IDDM). We have developed a quantitative method to measure autoantibodies directed against T-lymphocytes, based on two-color fluorescence labeling of Wistar mononuclear cells and analysis of fluorescence by...


    pub_type: 杂志文章


    authors: Bertrand S,Vigeant C,Yale JF

    更新日期:1994-01-01 00:00:00

  • Heterogeneous Nuclear Ribonucleoprotein F Stimulates Sirtuin-1 Gene Expression and Attenuates Nephropathy Progression in Diabetic Mice.

    abstract::We investigated the mechanism of heterogeneous nuclear ribonucleoprotein F (hnRNP F) renoprotective action in a type 2 diabetes (T2D) mouse model (db/db). Immortalized rat renal proximal tubular cells (IRPTCs) and kidneys from humans with T2D were also studied. The db/db mice developed hyperglycemia, oxidative stress,...


    pub_type: 杂志文章


    authors: Lo CS,Shi Y,Chenier I,Ghosh A,Wu CH,Cailhier JF,Ethier J,Lattouf JB,Filep JG,Ingelfinger JR,Zhang SL,Chan JSD

    更新日期:2017-07-01 00:00:00

  • Increased frequency of apolipoprotein epsilon 4 allele in type II diabetes with hypercholesterolemia.

    abstract::The apolipoprotein E (apoE) phenotype and allele frequencies were examined in type II (non-insulin-dependent) diabetic patients with normolipidemia (n = 134) and hypercholesterolemia (type IIa hyperlipoproteinemia, n = 35; type IIb hyperlipoproteinemia, n = 42). The frequencies of apoE4-present phenotypes (apoE4/3, ap...


    pub_type: 杂志文章


    authors: Eto M,Watanabe K,Iwashima Y,Morikawa A,Chonan N,Oshima E,Sekiguchi M,Ishii K

    更新日期:1987-11-01 00:00:00

  • β-Lapachone Prevents Diet-Induced Obesity by Increasing Energy Expenditure and Stimulating the Browning of White Adipose Tissue via Downregulation of miR-382 Expression.

    abstract::There has been great interest in the browning of fat for the treatment of obesity. Although β-lapachone (BLC) has potential therapeutic effects on obesity, the fat-browning effect and thermogenic capacity of BLC on obesity have never been demonstrated. Here, we showed that BLC stimulated the browning of white adipose ...


    pub_type: 杂志文章


    authors: Choi WH,Ahn J,Jung CH,Jang YJ,Ha TY

    更新日期:2016-09-01 00:00:00

  • Insulin-induced alterations in insulin binding and insulin action in primary cultures of rat hepatocytes.

    abstract::The exposure of primary cultures of hepatocytes to insulin. 10(-8) M, for 16 h results in a decrease in high affinity insulin binding with no alterations in lower affinity binding. This is reflected in a decrease in the sensitivity, but normal responsiveness, of cultured hepatocytes to the acute effect of insulin on t...


    pub_type: 杂志文章


    authors: Amatruda JM,Newmeyer HW,Chang CL

    更新日期:1982-02-01 00:00:00

  • Fat Mass Reduction With Adipocyte Hypertrophy and Insulin Resistance in Heterozygous PPARγ Mutant Rats.

    abstract::Agonist-induced activation of peroxisome proliferator-activated receptor-γ (PPARγ) stimulates adipocyte differentiation and insulin sensitivity. Patients with heterozygous PPARγ dominant-negative mutation develop partial lipodystrophy and insulin resistance. Inconsistent with this evidence in humans, it was reported t...


    pub_type: 杂志文章


    authors: Gumbilai V,Ebihara K,Aizawa-Abe M,Ebihara C,Zhao M,Yamamoto Y,Mashimo T,Hosoda K,Serikawa T,Nakao K

    更新日期:2016-10-01 00:00:00

  • "Cytoplasmic" islet cell antibodies. Evidence that the target antigen is a sialoglycoconjugate.

    abstract::We have biochemically treated (periodate, borohydride, neuraminidase, organic solvents) frozen sections of human pancreas and studied the reactivity of islet-cell-antibody-positive human sera and monoclonal antibodies. The autoantigen of pancreatic sections has the properties of sialic acid containing glycolipid. ...


    pub_type: 杂志文章


    authors: Nayak RC,Omar MA,Rabizadeh A,Srikanta S,Eisenbarth GS

    更新日期:1985-06-01 00:00:00

  • Endogenous glucose production and glucose effectiveness in type 2 diabetic subjects derived from stable-labeled minimal model approach.

    abstract::Insulin sensitivity, glucose effectiveness, and endogenous glucose production (EGP) during stable-labeled, frequently sampled insulin-modified intravenous glucose tolerance test (FSIGT) were evaluated by a single-and two-compartment minimal model combined with nonparametric deconvolution in eleven nonobese Japanese ty...


    pub_type: 杂志文章


    authors: Nagasaka S,Tokuyama K,Kusaka I,Hayashi H,Rokkaku K,Nakamura T,Kawakami A,Higashiyama M,Ishikawa S,Saito T

    更新日期:1999-05-01 00:00:00

  • Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion.

    abstract::Leptin, encoded for by the mouse ob gene, regulates feeding behavior and energy metabolism. Its receptor (Ob-R) is encoded by the mouse diabetic (db) gene and is mutated in the db/db mouse so that it lacks the cytoplasmic domain. We show that the full-length leptin receptor (Ob-Rb), which is believed to transmit the l...


    pub_type: 杂志文章


    authors: Emilsson V,Liu YL,Cawthorne MA,Morton NM,Davenport M

    更新日期:1997-02-01 00:00:00

  • Dynamics of glucose-induced localization of PKC isoenzymes in pancreatic beta-cells: diabetes-related changes in the GK rat.

    abstract::Glucose metabolism affects most major signal pathways in pancreatic beta-cells. Multiple protein kinases, including protein kinase C (PKC) isoenzymes, are involved in these effects; however, their role is poorly defined. Moreover, the dynamics of kinase isoenzyme activation in reference to the biphasic insulin secreti...


    pub_type: 杂志文章


    authors: Warwar N,Efendic S,Ostenson CG,Haber EP,Cerasi E,Nesher R

    更新日期:2006-03-01 00:00:00

  • Kinetics of in vivo muscle insulin-mediated glucose uptake in human obesity.

    abstract::The kinetics of in vivo insulin-mediated glucose uptake in human obesity have not been previously studied. To examine this, we used the glucose-clamp technique to measure whole-body and leg muscle glucose uptake in seven lean and six obese men during hyperinsulinemia (approximately 2000 pM) at four glucose levels (app...


    pub_type: 杂志文章


    authors: Laakso M,Edelman SV,Olefsky JM,Brechtel G,Wallace P,Baron AD

    更新日期:1990-08-01 00:00:00

  • How to protect the kidney in diabetic patients: with special reference to IDDM.

    abstract::During the development to overt nephropathy, diabetic patients go through several characteristic stages of renal disease, moving from normo- to micro- to macroalbuminuria. Microalbuminuria is defined as a urinary albumin excretion between 20 and 200 microg/min; values <20 microg/min are designated as normoalbuminuria,...


    pub_type: 杂志文章,评审


    authors: Mogensen CE

    更新日期:1997-09-01 00:00:00

  • The prognostic importance of plasma glucose levels and of the use of oral hypoglycemic drugs after myocardial infarction in men.

    abstract::The relationship of plasma glucose levels to risk of death over a five-year follow-up period was studied in 2,770 male survivors of myocardial infarction in the placebo group of the Coronary Drug Project (CDP). In univariate analyses, a positive association was observed between mortality rates and both fasting and one...


    pub_type: 临床试验,杂志文章



    更新日期:1977-05-01 00:00:00

  • Autoimmunity to insulin, beta cell dysfunction, and development of insulin-dependent diabetes mellitus.

    abstract::Circulating insulin autoantibodies (INSAAb) were measured in discordant monozygotic twins, first-degree relatives, and other groups at "high risk" for the development of insulin-dependent diabetes mellitus (IDDM), and these results correlated with both islet cell antibody (ICAb) status and beta cell function. INSAAb w...


    pub_type: 杂志文章


    authors: Srikanta S,Ricker AT,McCulloch DK,Soeldner JS,Eisenbarth GS,Palmer JP

    更新日期:1986-02-01 00:00:00

  • Partial Disruption of Lipolysis Increases Postexercise Insulin Sensitivity in Skeletal Muscle Despite Accumulation of DAG.

    abstract::Type 2 diabetes and skeletal muscle insulin resistance have been linked to accumulation of the intramyocellular lipid-intermediate diacylglycerol (DAG). However, recent animal and human studies have questioned such an association. Given that DAG appears in different stereoisomers and has different reactivity in vitro,...


    pub_type: 杂志文章


    authors: Serup AK,Alsted TJ,Jordy AB,Schjerling P,Holm C,Kiens B

    更新日期:2016-10-01 00:00:00

  • New monoclonal antibody diagnostic reagents for type I diabetes: differential lymphocyte surface antigen expression related to disease.

    abstract::New cellular-based reagents are needed to diagnose type I diabetes as well as to monitor the outcomes of clinical trials at early time points. Four new monoclonal antibodies (mAbs) have been shown to demonstrate reduced binding to lymphocytes from identical twins with long-term type I diabetes relative to that observe...


    pub_type: 杂志文章


    authors: Pinies JA,Fu Y,Vazquez JA,Faustman D

    更新日期:1997-03-01 00:00:00

  • Insulin-potentiating action of a synthetic amino-terminal fragment of human growth hormone (hGH 1--15) in streptozotocin-diabetic rats.

    abstract::The hypoglycemic activity of the synthetic peptide fragment of human growth hormone, hGH 1--15, is insulin dependent, although it does not alter the circulating levels of plasma insulin in normal and diabetic rats. In severe diabetes induced by streptozotocin, the peptide had no effect on the basal levels of blood glu...


    pub_type: 杂志文章


    authors: Ng FM,Bornstein J

    更新日期:1979-12-01 00:00:00