Amniotic fluid acetylcholinesterase: implications of an inconclusive result.

Abstract:

:The implications of an "inconclusive" acetylcholinesterase test (a faint but true band) in amniotic fluid were studied over a 2 1/2-year period in our laboratory. One thousand one hundred fifty-four amniotic fluid samples were tested for acetylcholinesterase and alpha-fetoprotein; the rate of an inconclusive acetylcholinesterase result was 3.3% (38 of 1154). Fourteen such results were found in patients with a high amniotic fluid alpha-fetoprotein level (23.3%), and 24 results were associated with normal amniotic fluid alpha-fetoprotein levels (2.19%). The rates of congenital fetal malformation associated with an inconclusive acetylcholinesterase result in the two groups were 57.14% and 37.5%, respectively. In amniotic fluid samples obtained before 15 weeks' gestation, there was a higher rate of inconclusive acetylcholinesterase tests (9.29%), but a lower percentage of malformed fetuses were found compared with later in pregnancy (2.46% and 56%, respectively). Thus we suggest the terminology "equivocal" for early specimens and "suspicious" for later specimens. If obtained in early second trimester and the ultrasound scan is normal, such findings implicate the need for a careful search for fetal malformations. A positive pregnancy outcome may be expected in most cases.

journal_name

Am J Obstet Gynecol

authors

Drugan A,Syner FN,Belsky R,Koppitch FC 3rd,Evans MI

doi

10.1016/s0002-9378(88)80111-x

subject

Has Abstract

pub_date

1988-08-01 00:00:00

pages

469-74

issue

2

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(88)80111-X

journal_volume

159

pub_type

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