Abstract:
BACKGROUND AND PURPOSE:Many clinical trials have shown that 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) can significantly reduce coronary artery disease in both primary and secondary prevention. A recent study showed that aggressive lipid-lowering therapy with strong statins could achieve coronary artery plaque regression, as evaluated with gray-scale intravascular ultrasound (IVUS). However, it is unknown whether coronary plaque regression and stabilization are reinforced when eicosapentaenoic acid (EPA) is used with a strong statin. METHODS AND SUBJECTS:We aim to assess patients with stable angina or acute coronary syndrome who had undergone successful percutaneous coronary intervention (PCI) with integrated backscatter IVUS (IB-IVUS) guidance. They will be randomly allocated to receive pitavastatin (4mg), or pitavastatin (4mg) plus EPA (1800mg), and prospectively followed for 6-8 months. RESULTS:The primary endpoint will be changes in tissue characteristics in coronary plaques, evaluated by IB-IVUS, and secondary endpoints will include absolute changes in coronary plaque volume, serum lipid levels, and inflammatory markers. The safety profile will also be evaluated. CONCLUSIONS:The combination therapy of EPA and pitavastatin for regression of coronary plaque evaluated by IB-IVUS (CHERRY) study will be the first multicenter study using IB-IVUS to investigate the effects of combination therapy with pitavastatin and EPA on coronary plaque volume and tissue characteristics.
journal_name
J Cardioljournal_title
Journal of cardiologyauthors
Watanabe T,Miyamoto T,Miyasita T,Shishido T,Arimoto T,Takahashi H,Nishiyama S,Hirono O,Matsui M,Sugawara S,Ikeno E,Miyawaki H,Akira F,Kubota Idoi
10.1016/j.jjcc.2013.12.008subject
Has Abstractpub_date
2014-09-01 00:00:00pages
236-9issue
3eissn
0914-5087issn
1876-4738pii
S0914-5087(14)00011-2journal_volume
64pub_type
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