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Clinical findings of gadolinium-enhanced cardiac magnetic resonance in Fabry patients.

Abstract：

BACKGROUND:Fabry disease is one of the causes of left ventricular hypertrophy (LVH) and can be treated with enzyme replacement therapy or pharmacological chaperone therapy. Late gadolinium enhancement (LGE) in cardiac magnetic resonance (CMR) can identify myocardial fibrosis and be used for the stratification in LVH. However, the details of the prevalence and characteristics of LGE in Japanese Fabry patients have not been reported. METHODS:We evaluated myocardial involvement in 26 Fabry patients (10 males, 16 females) using gadolinium-enhanced CMR. LGE areas were analyzed using the previously reported scoring method. Echocardiography was also performed to evaluate the left ventricular function and left ventricular mass. RESULTS:LGE on CMR images was positive in 5 out of 26 patients, and all patients with LGE-positive findings suffered from LVH (2 out of 5 male patients and 3 out of 4 female patients with LVH on echocardiography). LGE was specifically localized at the mid-wall in the infero-lateral area of the left ventricle. LGE-positive patients seemed to be older, and tended to have a larger left ventricular mass index and higher B-type natriuretic peptide level than LGE-negative patients. CONCLUSIONS:These results revealed that specific localization of LGE was present in Fabry patients.

journal_name

J Cardiol

journal_title

Journal of cardiology

authors

Nojiri A,Anan I,Morimoto S,Kawai M,Sakuma T,Kobayashi M,Kobayashi H,Ida H,Ohashi T,Eto Y,Shibata T,Yoshimura M,Hongo K

doi

10.1016/j.jjcc.2019.09.002

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

27-33

issue

1

eissn

0914-5087

issn

1876-4738

pii

S0914-5087(19)30292-8

journal_volume

75

pub_type

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