The effect of potassium ion depletion on postinfarction canine cardiac arrhythmias.

Abstract:

:The effect of potassium ion (K+) depletion on postmyocardial infarction ventricular arrhythmias was investigated in 32 dogs: 12 control animals, 10 animals that ate a diet extremely low in K+ for 15 days, and 10 others that, in addition to dietary K+ deprivation, received 50 mg of hydrochlorothiazide four times. The experimental myocardial infarction was created by proximal left anterior descending coronary artery ligation. In a subgroup of 24 animals selected for relatively uniform size of myocardial infarction (14% to 22% of left ventricular mass), eight animals with mean cumulative K+ balance of -4.01 +/- 2.19 meq/kg developed spontaneous ventricular fibrillation within 4 to 17 min of coronary ligation, whereas 16 animals with a mean cumulative K+ balance of -0.11 +/- 1.82 meq/kg didn't. By univariate analysis cumulative K+ deficit (p = .001) and plasma K+ concentration (p = .039) correlated significantly with spontaneous ventricular fibrillation. Multivariate analysis of the entire population of 32 animals identified cumulative K+ deficit and size of myocardial infarction as the only independent predictors of ventricular fibrillation. Cumulative K+ deficit was also an independent predictor of ventricular fibrillation induced by programmed cardiac stimulation in the conscious state 1 day after myocardial infarction.

journal_name

Circulation

journal_title

Circulation

authors

Garan H,McGovern BA,Canzanello VJ,McCauley J,Bodvarsson M,Harrington JT,Madias NE,Newell JB,Ruskin JN

doi

10.1161/01.cir.77.3.696

subject

Has Abstract

pub_date

1988-03-01 00:00:00

pages

696-704

issue

3

eissn

0009-7322

issn

1524-4539

journal_volume

77

pub_type

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