Global identification of genes targeted by DNMT3b for epigenetic silencing in lung cancer.

abstract：:The most ominous development in tumor progression is the transition to an invasive and metastatic phenotype. Little is known, however, about the molecular alterations that cause a tumor to become invasive. In view of this, we have used microarray expression analysis to evaluate the expression profiles of a unique pane...

journal_title：Oncogene

authors： Manos EJ,Kim ML,Kassis J,Chang PY,Wells A,Jones DA

更新日期：2001-05-17 00:00:00

abstract：:Glioma stem cells (GSCs) decrease T cells cognition and evade systemic immunosurveillance via downregulations or defects of major histocompatibility complex class I (MHC-I) molecule and antigen-processing machinery (APM) components. Improvement of tumor surface antigens of GSCs may be effective strategy to trigger an ...

journal_title：Oncogene

authors： Yang W,Li Y,Gao R,Xiu Z,Sun T

更新日期：2020-01-01 00:00:00

abstract：:We report chromosome 3p deletion mapping of 32 cervical carcinoma (CC) biopsies using 26 microsatellite markers located in frequently deleted 3p regions to detect loss of heterozygosity and homozygous loss. In addition, two STS markers (NLJ-003 and NL3-001) located in the 3p21.3 telomeric (3p21.3T) and 3p21.3 centrome...

journal_title：Oncogene

authors： Senchenko V,Liu J,Braga E,Mazurenko N,Loginov W,Seryogin Y,Bazov I,Protopopov A,Kisseljov FL,Kashuba V,Lerman MI,Klein G,Zabarovsky ER

更新日期：2003-05-15 00:00:00

abstract：:The mitotic spindle is assembled by the coordinated action of centrosomes and kinetochore microtubules. An evolutionally conserved protein family, transforming acidic coiled-coil (TACC), has been shown to be involved in this process. In humans, TACC3 is aberrantly expressed in a variety of human cancers, but its biolo...

journal_title：Oncogene

authors： Yao R,Kondoh Y,Natsume Y,Yamanaka H,Inoue M,Toki H,Takagi R,Shimizu T,Yamori T,Osada H,Noda T

更新日期：2014-08-14 00:00:00

abstract：:Previous studies have documented that Tumor necrosis factor alpha (TNFalpha) is a potent negative regulator of normal hematopoiesis. However, the mechanism by which TNFalpha acts at the cellular level is not totally understood. Although apoptotic cell killing appears to be the most common cellular effect of TNFalpha, ...

journal_title：Oncogene

authors： Beyne-Rauzy O,Recher C,Dastugue N,Demur C,Pottier G,Laurent G,Sabatier L,Mansat-De Mas V

更新日期：2004-09-30 00:00:00

abstract：:c-myc is a proto-oncogene essential for cell growth. When activated, its expression can lead to uncontrolled cell proliferation, transformation and tumorigenesis. The cell line tEMmyc4 is a murine myelomonocytic cell line that was established following transformation by v-myc. It has a high level of v-myc expression a...

journal_title：Oncogene

authors： Dolnikov A,Ward RL,Hawkins NJ,Symonds G

更新日期：1996-03-21 00:00:00

abstract：:The ETS transcription factor ERG has been implicated as a major regulator of both normal and aberrant hematopoiesis. In acute myeloid leukemias harboring t(16;21), ERG function is deregulated due to a fusion with FUS/TLS resulting in the expression of a FUS-ERG oncofusion protein. How this oncofusion protein deregulat...

journal_title：Oncogene

authors： Sotoca AM,Prange KH,Reijnders B,Mandoli A,Nguyen LN,Stunnenberg HG,Martens JH

更新日期：2016-04-14 00:00:00

abstract：:The heterogeneous breast cancers can be classified into different subtypes according to their histopathological characteristics and molecular signatures. Foxa1 expression is linked with luminal breast cancer (LBC) with good prognosis, whereas Twist1 expression is associated with basal-like breast cancer (BLBC) with po...

journal_title：Oncogene

authors： Xu Y,Qin L,Sun T,Wu H,He T,Yang Z,Mo Q,Liao L,Xu J

更新日期：2017-02-23 00:00:00

abstract：:The growth and dissemination of tumors rely on an altered vascular network, which supports their survival and expansion and provides accessibility to the vasculature and a route of transport for metastasizing tumor cells. The remodeling of vascular structures through generation of new vessels (for example, via tumor a...

journal_title：Oncogene

authors： Farnsworth RH,Lackmann M,Achen MG,Stacker SA

更新日期：2014-07-03 00:00:00

abstract：:RasGRP1 is a Ras-specific exchange factor, which is activated by T-cell receptor (TCR) and promotes TCR-dependent positive selection of thymocytes. RasGRP1 is highly expressed on most T lymphocytic leukemias and is a common site of proviral insertion in retrovirus-induced murine T-cell lymphomas. We used RasGRP1 trans...

journal_title：Oncogene

authors： Klinger MB,Guilbault B,Goulding RE,Kay RJ

更新日期：2005-04-14 00:00:00

abstract：:Glioblastoma (GBM) is a highly malignant glioma, which has the propensity to infiltrate throughout the brain in contrast to pilocytic astrocytoma (PA) of the posterior fossa, which does not spread and can be cured by surgery. We have used Suppression Subtractive Hybridization to define markers that better delineate th...

journal_title：Oncogene

authors： Colin C,Baeza N,Bartoli C,Fina F,Eudes N,Nanni I,Martin PM,Ouafik L,Figarella-Branger D

更新日期：2006-05-04 00:00:00

abstract：:The p14ARF tumor suppressor is a key regulator of cellular proliferation, frequently inactivated in human cancer. The mechanisms that regulate alternative reading frame (ARF) turnover have been obscure for long time, being ARF a relatively stable protein. Recently, it has been described that its degradation depends, a...

journal_title：Oncogene

authors： Pollice A,Sepe M,Villella VR,Tolino F,Vivo M,Calabrò V,La Mantia G

更新日期：2007-08-02 00:00:00

abstract：:We have previously shown that the death receptor ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) induces an increase of intracellular C(16)-ceramide in sensitive SW480 but not in resistant SW620 cells. Resistance in SW620 cells was overcome by exogenous ceramide, leading us to propose that defec...

journal_title：Oncogene

authors： White-Gilbertson S,Mullen T,Senkal C,Lu P,Ogretmen B,Obeid L,Voelkel-Johnson C

更新日期：2009-02-26 00:00:00

abstract：:The E3 ligase S-phase kinase-associated protein 2(Skp2) is overexpressed in human cancers and correlated with poor prognosis, but its contributions to tumorigenesis and chemoresistance in nasopharyngeal carcinoma (NPC) are not evident. Herein we show that Skp2 is highly expressed in NPC tumor tissues and cell lines. K...

journal_title：Oncogene

authors： Yu X,Wang R,Zhang Y,Zhou L,Wang W,Liu H,Li W

更新日期：2019-12-01 00:00:00

abstract：:Survivin is a member of the inhibitor of apoptosis (IAP) gene family that has attracted attention from several viewpoints of basic and translational research. Its cell cycle-regulated expression at mitosis and association with the mitotic apparatus have been of interest to cell biologists studying faithful segregation...

journal_title：Oncogene

authors： Altieri DC

更新日期：2003-11-24 00:00:00

abstract：:c-Myc promotes cellular proliferation, sensitizes cells to apoptosis and prevents differentiation. It binds cyclin T1 structurally and functionally from the positive transcription elongation factor b (P-TEFb). The cyclin-dependent kinase 9 (Cdk9) in P-TEFb then phosporylates the C-terminal domain of RNA polymerase II,...

journal_title：Oncogene

authors： Kanazawa S,Soucek L,Evan G,Okamoto T,Peterlin BM

更新日期：2003-08-28 00:00:00

abstract：:Since defects in molecular mechanisms controlling DNA repair, cell cycle checkpoint and apoptosis could modify cellular sensitivity to DNA damaging agents, we have conducted a multiparametric molecular analysis for better understanding the regulation pathways leading to cell survival or cell death after irradiation. U...

journal_title：Oncogene

authors： Bishay K,Ory K,Lebeau J,Levalois C,Olivier MF,Chevillard S

更新日期：2000-02-17 00:00:00

abstract：:The MT-2 cell-line, which had been established through in vitro cell to cell transmission of human T-cell leukemia virus type I (HTLV-I) among human primary lymphocytes, was shown to possess multiple copies of integrated proviruses, including defective proviral genomes. By analysing a genomic clone, we identified the ...

journal_title：Oncogene

authors： Kubota S,Siomi H,Hatanaka M,Pomerantz RJ

更新日期：1996-04-04 00:00:00

abstract：:cDNA clones of human fos-related genes fra-1 and fra-2 were isolated by screening human c-DNA libraries with human fos DNA as a probe. We obtained human fra-1 cDNA clones that can code for a protein of 271 amino acid residues with a calculated molecular weight of 29,413 and showed 90% similarity with rat fra-1 protein...

journal_title：Oncogene

authors： Matsui M,Tokuhara M,Konuma Y,Nomura N,Ishizaki R

更新日期：1990-03-01 00:00:00

abstract：:Human basal cell cancer (BCC) has unique growth characteristics with virtual inability to metastasize. We investigated clonality and genetic progression using p53 mutations as marker. Sampling was done through microdissection of frozen immunohistochemically stained 16 microm slices of tumors. From 11 BCC tumors 78 sam...

journal_title：Oncogene

authors： Pontén F,Berg C,Ahmadian A,Ren ZP,Nistér M,Lundeberg J,Uhlén M,Pontén J

更新日期：1997-08-28 00:00:00

abstract：:Transformed cells express high levels of non-telomeric reverse-transcriptase (RT) activity of retrotransposon and endogenous retrovirus origin. We previously reported that RT inhibition, either pharmacological or through transient silencing of RT-encoding LINE-1 (L1) elements by RNA interference (RNAi), reduced prolif...

journal_title：Oncogene

authors： Oricchio E,Sciamanna I,Beraldi R,Tolstonog GV,Schumann GG,Spadafora C

更新日期：2007-06-21 00:00:00

abstract：:Skin carcinogenesis is known to be a multi-step process with several stages along its malignant evolution. We hypothesized that transformation of normal epidermis to cutaneous squamous cell carcinoma (cSCC) is causally linked to alterations in microRNAs (miRNA) expression. For this end we decided to evaluate their alt...

journal_title：Oncogene

authors： Mizrahi A,Barzilai A,Gur-Wahnon D,Ben-Dov IZ,Glassberg S,Meningher T,Elharar E,Masalha M,Jacob-Hirsch J,Tabibian-Keissar H,Barshack I,Roszik J,Leibowitz-Amit R,Sidi Y,Avni D

更新日期：2018-01-11 00:00:00

abstract：:Activation of Stat5 by many cytokines implies that it cannot alone insure the specificity of the regulation of its target genes. We have evidenced a physical and functional interaction between members of two unrelated transcription factor families, Ets-1, Ets-2 and Stat5, which could contribute to the proliferative re...

journal_title：Oncogene

authors： Rameil P,Lécine P,Ghysdael J,Gouilleux F,Kahn-Perlès B,Imbert J

更新日期：2000-04-20 00:00:00

abstract：:Smad4 is a critical component in transforming growth factor beta (TGF-beta) signaling and frequently mutated in pancreatic and colorectal cancers. Smad4 has two important functional domains, MH1 and MH2, that are involved in different biological processes. The MH1 domain comprises a DNA binding domain and the MH2 doma...

journal_title：Oncogene

authors： Kuang C,Chen Y

更新日期：2004-02-05 00:00:00

abstract：:Wild-type p53 is stabilized and accumulates in the nucleus of DNA damaged cells. The effect of stabilizing p53 is to inhibit cell growth, either through a G1 cell cycle arrest or apoptotic cell death. MDM2 can inhibit p53 activity, in part, by promoting its rapid degradation through the ubiquitin proteolysis pathway. ...

journal_title：Oncogene

authors： Yu ZK,Geyer RK,Maki CG

更新日期：2000-11-30 00:00:00

abstract：:Our recent study showed critical roles of Dmp1 as a sensor of oncogenic Ras, HER2/neu signaling and activation of the Arf-p53 pathway. To elucidate the role of human DMP1 (hDMP1) in breast cancer, one hundred and ten pairs of human breast cancer specimen were studied for the alterations of the hDMP1-ARF-Hdm2-p53 pathw...

journal_title：Oncogene

authors： Maglic D,Zhu S,Fry EA,Taneja P,Kai F,Kendig RD,Sugiyama T,Miller LD,Willingham MC,Inoue K

更新日期：2013-08-29 00:00:00

abstract：:The tumor suppressor gene p53 is a potent transcriptional regulator of genes which are involved in many cellular activities including cell cycle arrest, apoptosis, and angiogenesis. Recent studies have demonstrated that the activation of the transcriptional factor nuclear factor kappaB (NF-kappaB) plays an essential r...

journal_title：Oncogene

authors： Shao J,Fujiwara T,Kadowaki Y,Fukazawa T,Waku T,Itoshima T,Yamatsuji T,Nishizaki M,Roth JA,Tanaka N

更新日期：2000-02-10 00:00:00

abstract：:We recently reported an interaction between the p14(ARF) protein and human topoisomerase I (Topo I) resulting in the stimulation of the relaxation activity of Topo I. Our data showed that the complex between the two proteins was located within the nucleolus. In the present work, we have investigated the regions of p14...

journal_title：Oncogene

authors： Ayrault O,Karayan L,Riou JF,Larsen CJ,Séité P

更新日期：2003-04-03 00:00:00

abstract：:Activating mutations of K-ras are frequent in colon tumors and aberrant crypt foci, and may play important roles in colon carcinogenesis. Here, we investigated the effects of a K-ras codon 12 mutation on inducible nitric oxide synthase (iNOS) expression. When rat intestinal epithelial cells (IEC-6) were transfected wi...

journal_title：Oncogene

authors： Takahashi M,Mutoh M,Shoji Y,Kamanaka Y,Naka M,Maruyama T,Sugimura T,Wakabayashi K

更新日期：2003-10-23 00:00:00

abstract：:Arg and c-Abl represent the mammalian member of the Abelson family of nonreceptor protein tyrosine kinases. The two proteins are composed of SH2, SH3, kinase and C-terminal domains. To examine Arg structure-function relationships we analysed a Gag-Arg fusion protein, analogous to the oncogenic Gag-Abl fusion protein o...

journal_title：Oncogene

authors： Mysliwiec T,Perego R,Kruh GD

更新日期：1996-02-01 00:00:00