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A severe Whipple disease with an immune reconstitution inflammatory syndrome: an additional case of thalidomide efficiency.

Abstract：

:We report the case of a 38-year-old man who presented with severe diarrhea, weight loss of 10 kg, ankles paresthesia and severe motor weakness in the left fibular nerve territory after introduction of azathioprine and corticosteroid for proteinuria. Coloscopy and gastroscopy revealed a typical aspect of Whipple disease (WD), associated with both positive PAS staining and specific immunohistochemistry. T. whipplei PCR results were positive in blood, faeces, saliva and duodenal biopsy specimens. Diagnosis of WD with systemic manifestations was retained and doxycycline plus hydroxychloroquine therapy were started. This treatment improved joint pain, and skin and intestinal symptoms. One month later, our patient presented with fever and an important inflammatory syndrome (CRP 150 mg/dL and 16.8 10(9)/L leukocytes), while no infection was found despite a thorough review. We concluded it was an immune reconstitution inflammatory syndrome (IRIS). Manifestations persisted despite increasing corticosteroids and thalidomide (200 mg/day) was introduced with good efficacy on these symptoms. WD may be revealed by non-specific symptoms such as weight loss or arthralgia, but also by many other misleading signs. Our observation illustrates the highly polymorphic clinical presentation of WD, and the diagnostic difficulties that may arise. This is also a new report of thalidomide effectiveness in IRIS in WD.

journal_name

Joint Bone Spine

journal_title

Joint bone spine

authors

Le Blay P,Rakotonirainy H,Lagier JC,Raoult D,Puechal X,Pers YM

doi

10.1016/j.jbspin.2013.10.007

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

260-2

issue

3

eissn

1297-319X

issn

1778-7254

pii

S1297-319X(13)00247-9

journal_volume

81

pub_type

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