当前位置： SCI文献检索 > JOINT BONE SPINE期刊下所有文献 > Rheumatoid factors, anti-filaggrin antibodies and low in vitro interleukin-2 and interferon-gamma production are useful immunological markers for early diagnosis of community cases of rheumatoid arthritis. A preliminary study.

Rheumatoid factors, anti-filaggrin antibodies and low in vitro interleukin-2 and interferon-gamma production are useful immunological markers for early diagnosis of community cases of rheumatoid arthritis. A preliminary study.

Abstract：

OBJECTIVE:To determine whether measurements of different autoantibodies (Ab) and cytokines are useful to distinguish very early rheumatoid arthritis (RA) from other inflammatory rheumatisms. METHODS:From a population-based recruitment, 32 patients with very early polyarthritis (median duration: 4 months) were studied. Evaluations at entry (M0), and at 6 (M6) and 12 months (M12). Ab tested: rheumatoid factors (RF) by agglutination methods and ELISA, antiperinuclear factor (APF), antikeratin Ab (AKA), anti-Sa and antinuclear Ab. Cytokine production (TNFalpha, IL2, IFNgamma, IL1beta, IL10) in whole blood cell culture (WBCC) was determined at M0. At M12, patients were classified as having RA (N = 15) or other rheumatic diseases. RESULTS:At M0, AKA/APF and anti-Sa Ab frequencies were low, 13% and 7%, respectively. While most Ab detected at M0 persisted, others appeared during follow-up, particularly APF, which rose from 13 to 40% at M12. At M6, IgM-RF was detected in two RA patients exclusively by ELISA. AKA/APF were found to be highly specific markers for RA (100% specificity). At some time during follow-up, two RF-negative RA patients were AKA-positive. In two patients, AKA and APF were present at M0 before they satisfied ACR criteria. IL2 and IFNgamma production was significantly lower (P < 0.05) for RA patients. CONCLUSION:AKA/APF and anti-Sa Ab were detected in community cases of very early RA. AKA/APF and RF detected by ELISA might contribute to an earlier diagnosis of RA. Low production of IFNgamma and IL2 in WBCC constituted a distinct immunopathological feature in very early RA patients.

journal_name

Joint Bone Spine

journal_title

Joint bone spine

authors

Vittecoq O,Jouen-Beades F,Krzanowska K,Bichon-Tauvel I,Ménard JF,Daragon A,Tron F,Le Loët X

doi

10.1016/s1297-319x(00)00244-x

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

144-53

issue

2

eissn

1297-319X

issn

1778-7254

pii

S1297-319X(00)00244-X

journal_volume

68

pub_type

临床试验,杂志文章

相关文献

JOINT BONE SPINE文献大全
  • Profile of autoantibodies in Jaccoud's arthropathy.

    abstract：OBJECTIVE:To compare the frequency of different autoantibodies in a group of patients with Jaccoud's arthropathy (JA) secondary to systemic lupus erythematosus (SLE) with those without JA. METHODS:A group of SLE patients with JA was compared with another group of SLE patients without this complication, matched by age ...

    journal_title：Joint bone spine

    pub_type： 杂志文章

    doi：10.1016/j.jbspin.2008.11.003

    authors： Galvão V,Atta AM,Sousa Atta ML,Motta M,Dourado S,Grimaldi L,Oliveira e Silva N,Silva de Oliveira I,Santiago MB

    更新日期：2009-07-01 00:00:00

  • Anti-CRP antibodies in systemic lupus erythematosus.

    abstract：:C-reactive protein (CRP) is an acute-phase protein whose concentration rises sharply during the inflammatory response (1000-fold). CRP belongs to the pentraxin family of proteins, of which a key property is the ability to opsonize apoptotic cells, which can then undergo phagocytosis without triggering an inflammatory ...

    journal_title：Joint bone spine

    pub_type： 杂志文章,评审

    doi：10.1016/j.jbspin.2010.04.010

    authors： Meyer O

    更新日期：2010-10-01 00:00:00

  • A possible association between Chlamydiae psittacci infection and temporal arteritis.

    abstract：:Some arguments are in favor of the role of Chlamydia in the pathogenesis of atherosclerosis and some vasculitis. Illustrating this possible relation, we report the case of a patient developing consecutively a Chlamydia psittacci infection and a temporal arteritis. A 73-year-old woman, with no significant medical histo...

    journal_title：Joint bone spine

    pub_type： 杂志文章

    doi：10.1016/s1297-319x(00)00205-0

    authors： Bonnet F,Morlat P,Delevaux I,Gavinet AM,Parrens M,Bernard N,Lacoste D,Beylot J

    更新日期：2000-01-01 00:00:00

  • Non-biologic remission maintenance therapy in adult patients with ANCA-associated vasculitis: a systematic review and network meta-analysis.

    abstract：OBJECTIVE:To determine the comparative efficacy of non-biologic treatments for remission maintenance in ANCA-associated vasculitis. METHODS:We identified all randomized trials comparing leflunomide, azathioprine, methotrexate or mycophenolate mofetil in adult patients with granulomatosis with polyangiitis or microscop...

    journal_title：Joint bone spine

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.jbspin.2013.11.006

    authors： Hazlewood GS,Metzler C,Tomlinson GA,Gross WL,Feldman BM,Guillevin L,Pagnoux C

    更新日期：2014-07-01 00:00:00

  • Leflunomide-induced aseptic meningitis.

    abstract：:Drug-induced aseptic meningitis is uncommon and occurs primarily in patients with autoimmune disease. We report the first known case of leflunomide-induced aseptic meningitis, in a patient with rheumatoid arthritis. ...

    journal_title：Joint bone spine

    pub_type： 杂志文章

    doi：10.1016/S1297-319X(03)00127-1

    authors： Cohen JD,Jorgensen C,Sany J

    更新日期：2004-05-01 00:00:00

  • IgD kappa myeloma: a new case.

    abstract：UNLABELLED:IgD myeloma, which is particularly severe, accounts for only 1-3% of all myeloma cases, and the kappa subtype contributes only 10-30% of IgD myelomas. We report a new case. CASE-REPORT:A 59-year-old man was admitted for inflammatory low back pain with L5 sciatica and diffuse bone pain. The symptoms had been...

    journal_title：Joint bone spine

    pub_type： 杂志文章

    doi：10.1016/j.jbspin.2003.05.004

    authors： Amine B,Benbouazza K,Harzy T,Rahmouni R,Guedira N,Lazrak N,Hajjaj-Hassouni N

    更新日期：2004-07-01 00:00:00

  • Physical activity in patients with rheumatoid arthritis.

    abstract：INTRODUCTION:Rheumatoid arthritis (RA) is the most common chronic inflammatory joint disease and is associated with an excess risk of cardiovascular disease. For the general population, the World Health Organization has issued detailed recommendations on the type of physical activity appropriate for decreasing the card...

    journal_title：Joint bone spine

    pub_type： 杂志文章,评审

    doi：10.1016/j.jbspin.2015.10.002

    authors： Verhoeven F,Tordi N,Prati C,Demougeot C,Mougin F,Wendling D

    更新日期：2016-05-01 00:00:00

  • GOSPEL: prospective survey of gout in France. Part I: design and patient characteristics (n = 1003).

    abstract：OBJECTIVES:To assess diagnoses and management of acute and chronic gout in primary care and rheumatology settings relative to 2006 European League Against Rheumatism (EULAR) gout recommendations. Secondary objectives were to describe patient demographics, clinical features, lifestyle modifications, and short- and mid-t...

    journal_title：Joint bone spine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jbspin.2011.12.006

    authors： Lioté F,Lancrenon S,Lanz S,Guggenbuhl P,Lambert C,Saraux A,Chiarelli P,Delva C,Aubert JP,Ea HK

    更新日期：2012-10-01 00:00:00

  • Rituximab in rheumatoid arthritis and the risk of malignancies: report from a French cohort.

    abstract：OBJECTIVE:To determine in real-life conditions the safety of treatment with rituximab (RTX) in patients with rheumatoid arthritis (RA) regarding malignancies. METHODS:Analysis of safety data from a cohort of RA patients who received at least one course of RTX. RA patients with previous malignancies were followed-up an...

    journal_title：Joint bone spine

    pub_type： 杂志文章

    doi：10.1016/j.jbspin.2010.11.012

    authors： Slimani S,Lukas C,Combe B,Morel J

    更新日期：2011-10-01 00:00:00

  • Controversies in rheumatoid arthritis glucocorticoid therapy.

    abstract：:Despite therapeutic innovations in the past 20 years, glucocorticoids (GC) are still widely used for the symptomatic treatment of rheumatoid arthritis (RA). Studies have demonstrated the clinical and structural efficacy of moderate doses (i.e. 30-60 mg/d) GC in addition to disease modifying anti-rheumatic drug (DMARD)...

    journal_title：Joint bone spine

    pub_type： 杂志文章,评审

    doi：10.1016/j.jbspin.2017.12.002

    authors： Ruyssen-Witrand A,Constantin A

    更新日期：2018-07-01 00:00:00

  • Muscle involvement on 18F-FDG PET-CT in polymyalgia rheumatica. A controlled retrospective study of 101 patients.

    abstract：:18F-fluoro deoxy glucose PET scanner (18F-FDG-PET-CT) has shown its interest in the diagnosis of polymyalgia rheumatica (PMR) and makes possible to evaluate the metabolic activity of the entire musculoskeletal system and in particular muscular structures. The purpose of this study was to evaluate muscle involvement us...

    journal_title：Joint bone spine

    pub_type： 杂志文章

    doi：10.1016/j.jbspin.2020.01.006

    authors： Wendling D,Sondag M,Giraud N,Chouk M,Boulahdour H,Prati C,Verhoeven F

    更新日期：2020-05-01 00:00:00

  • Therapeutic strategy for rheumatoid arthritis patients who have achieved remission.

    abstract：:Once remission or low disease activity (LDA) is attained in established rheumatoid arthritis (RA) patients, attempting disease-modifying anti-rheumatic drug (DMARD) tapering appears to be a viable option to avoid patient overtreatment. Potential benefits include reduction in the treatment burden and the risk of advers...

    journal_title：Joint bone spine

    pub_type： 杂志文章,评审

    doi：10.1016/j.jbspin.2018.02.002

    authors： Fautrel B

    更新日期：2018-12-01 00:00:00

  • Vertebral involvement in Paget's disease: morphological classification of CT and MR appearances.

    abstract：:Vertebral Paget's disease produces a large panel of radiologic appearances sometimes atypical and pseudotumoral. Classical classifications of bone alterations based on pathophysiological hypotheses do not always match the imaging findings. This article will review the computed tomography (CT) and magnetic resonance im...

    journal_title：Joint bone spine

    pub_type： 杂志文章

    doi：10.1016/j.jbspin.2014.07.009

    authors： Dohan A,Parlier-Cuau C,Kaci R,Touraine S,Bousson V,Larédo JD

    更新日期：2015-01-01 00:00:00

  • Geoepidemiology of Sjögren's syndrome in Latin America.

    abstract：OBJECTIVE:To evaluate the geoepidemiology of Sjögren's syndrome (SS) in Latin America. METHODS:This was a three phase study in which original data from a Colombian cohort of patients with SS is presented, followed by a systematic review of Colombian and Latin American studies. Lastly, the geoepidemiology of SS in Lati...

    journal_title：Joint bone spine

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.jbspin.2019.02.004

    authors： Restrepo-Jiménez P,Molano-González N,Anaya JM

    更新日期：2019-10-01 00:00:00

  • Arthritis, tenosynovitis, fasciitis, and bursitis due to sea urchin spines. A series of 12 cases in Réunion Island.

    abstract：UNLABELLED:Arthritis, tenosynovitis, and bursitis due to sea urchin spine injuries have unique pathological features and run a chronic course until the spines are removed. Of the 40 cases of sea urchin spine-related clinical symptoms published to date, only 12 had osteoarticular symptoms. PATIENTS AND METHODS:We studi...

    journal_title：Joint bone spine

    pub_type： 杂志文章

    doi：

    authors： Guyot-Drouot MH,Rouneau D,Rolland JM,Solau-Gervais E,Cotten A,Flipo RM,Duquesnoy B

    更新日期：2000-01-01 00:00:00

  • Switching from originator infliximab to biosimilar CT-P13 in real-life: The weight of patient acceptance.

    abstract：OBJECTIVE:To explore acceptance and retention rate of biosimilar CT-P13 after switching from originator infliximab (OI) in patients with various rheumatic diseases. METHODS:Patients with stable rheumatoid arthritis (RA), ankylosing spondylitis (AS) or psoriatic arthritis (PsA) under OI were proposed to switch to CT-P1...

    journal_title：Joint bone spine

    pub_type： 杂志文章

    doi：10.1016/j.jbspin.2017.10.003

    authors： Scherlinger M,Germain V,Labadie C,Barnetche T,Truchetet ME,Bannwarth B,Mehsen-Cetre N,Richez C,Schaeverbeke T,FHU ACRONIM.

    更新日期：2018-10-01 00:00:00

  • Rosuvastatin inhibits spontaneous and IL-1β-induced interleukin-6 production from human cultured osteoblastic cells.

    abstract：OBJECTIVE:Experimental and clinical data suggest that statins may protect bone by inhibiting bone resorption and/or stimulating bone formation. Interleukin-6 (IL-6) is produced by osteoblasts, and potently stimulates osteoclast activation playing a key role in normal bone resorption as well as in post-menopausal and in...

    journal_title：Joint bone spine

    pub_type： 杂志文章

    doi：10.1016/j.jbspin.2012.07.007

    authors： Lazzerini PE,Capperucci C,Spreafico A,Capecchi PL,Niccolini S,Ferrata P,Frediani B,Galeazzi M,Laghi-Pasini F

    更新日期：2013-03-01 00:00:00

  • Pro-inflammatory effect of leptin on peripheral blood mononuclear cells of patients with ankylosing spondylitis.

    abstract：OBJECTIVES:This study was performed to investigate whether leptin mRNA expression is increased from peripheral blood mononuclear cells (PBMCs) of patients with active ankylosing spondylitis (AS) and whether it stimulates the production of pro-inflammatory cytokines. METHODS:Twenty patients with active AS were enrolled...

    journal_title：Joint bone spine

    pub_type： 杂志文章

    doi：10.1016/j.jbspin.2008.04.018

    authors： Park MC,Chung SJ,Park YB,Lee SK

    更新日期：2009-03-01 00:00:00

  • Influence of anti-infliximab antibodies and residual infliximab concentrations on the occurrence of acquired drug resistance to infliximab in rheumatoid arthritis patients.

    abstract：BACKGROUND:Infliximab (IFX) can be immunogenic for humans and lead to the formation of antibodies against IFX (anti-IFX Ab), which could induce acquired IFX resistance. OBJECTIVE:To test whether the presence of anti-IFX Ab and residual circulating IFX levels are associated with acquired IFX resistance in RA. METHODS:...

    journal_title：Joint bone spine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jbspin.2010.02.021

    authors： Finckh A,Dudler J,Wermelinger F,Ciurea A,Kyburz D,Gabay C,Bas S,physicians of SCQM.

    更新日期：2010-07-01 00:00:00

  • Diagnostic tools for amyloidosis.

    abstract：:Demonstration of amyloid deposits in biopsy specimens is the only means of confirming the diagnosis of amyloidosis. In experienced hands, nonsurgical biopsies of the rectal mucosa or, preferably, of the abdominal fat pad or labial salivary glands provide the diagnosis in 80 to 85% of cases. Immunolabeling studies help...

    journal_title：Joint bone spine

    pub_type： 杂志文章,评审

    doi：10.1016/s1297-319x(02)00449-9

    authors： Hachulla E,Grateau G

    更新日期：2002-12-01 00:00:00

  • Bone disease in cystic fibrosis: what's new?

    abstract：:Cystic fibrosis (CF) is the most common autosomal recessive disease among Caucasians. It is due to a mutation in the cftr gene, which encodes the CF transmembrane conductance regulator (CFTR), a chloride channel located in the plasma membrane of mucus-secreting epithelial cells. Numerous other functions of the CFTR pr...

    journal_title：Joint bone spine

    pub_type： 杂志文章,评审

    doi：10.1016/j.jbspin.2010.11.015

    authors： Javier RM,Jacquot J

    更新日期：2011-10-01 00:00:00

  • Fibrolipoma of the median nerve.

    abstract：:Neural fibrolipoma or fibrolipomatous hamartoma is an uncommon benign tumor that usually arises in the median nerve. Fibrofatty tissue proliferates around the nerve and infiltrates the epineurium and perineurium. We report a case of fibrolipomatous hamartoma of the left median nerve in an 18-year-old woman. Our object...

    journal_title：Joint bone spine

    pub_type： 杂志文章

    doi：10.1016/j.jbspin.2006.02.012

    authors： Nouira K,Belhiba H,Baccar S,Miaaoui A,Ben Messaoud M,Turki I,Cheour I,Menif E

    更新日期：2007-01-01 00:00:00

  • Predictors of disease flare after discontinuation of concomitant methotrexate in Japanese patients with rheumatoid arthritis treated with tocilizumab.

    abstract：OBJECTIVE:To investigate predictors of disease flare after methotrexate discontinuation in Japanese rheumatoid arthritis (RA) patients with sustained low disease activity undergoing tocilizumab plus methotrexate combination therapy. METHODS:Participants of this multicenter, open-label, uncontrolled, prospective study ...

    journal_title：Joint bone spine

    pub_type： 杂志文章

    doi：10.1016/j.jbspin.2020.06.001

    authors： Asai S,Takahashi N,Hayashi M,Hanabayashi M,Kanayama Y,Takemoto T,Yabe Y,Shioura T,Ishikawa H,Yoshioka Y,Kato T,Hirano Y,Fujibayashi T,Hattori Y,Kobayakawa T,Ando M,Kuwatsuka Y,Matsumoto T,Asai N,Sobue Y,Nishiume T

    更新日期：2020-12-01 00:00:00

  • Optimizing combination rifampin therapy for staphylococcal osteoarticular infections.

    abstract：:Staphylococcus spp. causes more than half of all osteoarticular infections of native structures or implanted material. The ability of Staphylococcus spp. to persist within infected bone tissue and to produce a bacterial biofilm, most notably in infections of implanted material, can lead to treatment failures and micro...

    journal_title：Joint bone spine

    pub_type： 杂志文章,评审

    doi：10.1016/j.jbspin.2012.09.008

    authors： Coiffier G,Albert JD,Arvieux C,Guggenbuhl P

    更新日期：2013-01-01 00:00:00

  • Endogenous sex steroids and bone mineral density in healthy men.

    abstract：OBJECTIVE:To evaluate the role of endogenous sex steroids on bone mineral density (BMD) in healthy Turkish men. METHODS:Serum total testosterone (TT), free testosterone (FT), dehydroepiandrosterone sulfate and estradiol levels were assayed in 174 healthy men of 240 volunteers, aged 22-76 years. Dual-energy X-ray absor...

    journal_title：Joint bone spine

    pub_type： 杂志文章

    doi：10.1016/j.jbspin.2005.04.003

    authors： Keleş I,Aydin G,Başar MM,Hayran M,Atalar E,Orkun S,Batislam E

    更新日期：2006-01-01 00:00:00

  • Hip dislocation revealing hip tuberculosis. A case report.

    abstract：:Hip dislocation is an uncommon presentation of hip tuberculosis. We report a case in an 18-year-old woman with active hip tuberculosis. An attempt to reduce the dislocation 7 weeks into antituberculous therapy was followed by necrosis of the femoral head. Although severe forms of hip tuberculosis are common in endemic...

    journal_title：Joint bone spine

    pub_type： 杂志文章

    doi：10.1016/s1297-319x(02)00459-1

    authors： El Hassani S,Benbouazza K,Allali F,Bensabbah R,Attaïbi A,Hajjaj-Hassouni N

    更新日期：2002-12-01 00:00:00

  • Shoulder surgery: from cuff repair to joint replacement. An update.

    abstract：:REPAIRING FULL THICKNESS CUFF TEARS.--Despite the sound rationale for repairing full-thickness rotator cuff tears, the procedure may fail to restore cuff integrity, which is indispensable to optimal cuff function. The functional role of each cuff muscle and the factors associated with anatomic failure (particularly th...

    journal_title：Joint bone spine

    pub_type：

    doi：10.1016/j.jbspin.2003.08.003

    authors： Goutallier D,Postel JM,Zilber S,Van Driessche S

    更新日期：2003-12-01 00:00:00

  • Mycophenolate mofetil as induction and long-term maintaining treatment in childhood: Primary angiitis of the central nervous system.

    abstract：OBJECTIVE:To report our single centre experience in treating 4 children affected by childhood primary central nervous system vasculitis (cPACNS) using mycophenolate mofetil (MMF). METHODS:From December 2011 to August 2015, 4 patients (3 males; age range: 9 months-13 years) affected by cPACNS were collected. Enrolled c...

    journal_title：Joint bone spine

    pub_type： 杂志文章

    doi：10.1016/j.jbspin.2016.12.004

    authors： Rosati A,Cosi A,Basile M,Brambilla A,Guerrini R,Cimaz R,Simonini G

    更新日期：2017-05-01 00:00:00

  • Factors associated with rapid progression to knee arthroplasty: complete analysis of three-year data from the osteoarthritis initiative.

    abstract：OBJECTIVES:Only a few studies have identified prognostic factors indicating risk of future knee arthroplasty in patients with osteoarthritis (OA) of the knee. The Osteoarthritis Initiative (OAI) is a National Institutes of Health and privately funded cohort study of 4796 persons with or at high risk of knee OA. The OAI...

    journal_title：Joint bone spine

    pub_type： 杂志文章

    doi：10.1016/j.jbspin.2011.05.005

    authors： Riddle DL,Kong X,Jiranek WA

    更新日期：2012-05-01 00:00:00

  • Patients' information and perspectives on biosimilars in rheumatology: A French nation-wide survey.

    abstract：OBJECTIVE:To assess the patients' information about biosimilars and to identify the patients' incentives and deterrents to concur with the use of biosimilars. METHODS:Nation-wide cross-sectional study assessing information and concerns about biosimilars of French patients treated for rheumatic inflammatory diseases, w...

    journal_title：Joint bone spine

    pub_type： 杂志文章

    doi：10.1016/j.jbspin.2019.01.001

    authors： Frantzen L,Cohen JD,Tropé S,Beck M,Munos A,Sittler MA,Diebolt R,Metzler I,Sordet C

    更新日期：2019-07-01 00:00:00