Effects of mesolimbic dopamine depletion on responding maintained by cocaine and food.

Abstract:

:The hypothesis that mesolimbic dopamine is selectively involved in cocaine reinforcement was investigated in the rat. Animals were trained under a multiple schedule in which responding was reinforced by intravenous cocaine (0.75 mg/kg/injection) or food (45-mg pellets) under fixed-ratio 15 schedule requirements in alternate 30-min components of a 2-hr daily session. Infusion of the catecholaminergic neurotoxin 6-hydroxydopamine, but not the vehicle solution, into the region of the nucleus accumbens and olfactory tubercle produced selective reductions in cocaine self-administration without significantly altering responding maintained by food within the same sessions. This effect was reproduced in intact animals by substituting saline for cocaine in the self-administration component. These results support the hypothesis that the reinforcing effects of cocaine are dependent upon mesolimbic dopamine and demonstrate that cocaine self-administration can be disrupted in animals without altering behavior maintained by a nondrug reinforcer.

journal_name

J Exp Anal Behav

authors

Caine SB,Koob GF

doi

10.1901/jeab.1994.61-213

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

213-21

issue

2

eissn

0022-5002

issn

1938-3711

journal_volume

61

pub_type

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