Combined antenatal thyrotropin-releasing hormone and low-dose glucocorticoid therapy improves the pulmonary biochemical immaturity in congenital diaphragmatic hernia.


:The lungs of patients born with severe congenital diaphragmatic hernia (CDH) are biochemically and morphologically immature. Because antenatal glucocorticoid therapy can accelerate pulmonary maturation in premature neonates who have respiratory distress syndrome, we hypothesized that it may correct the pulmonary biochemical and morphological immaturity associated with CDH. We showed in previous experimental studies that antenatal low-dose dexamethasone improved the biochemical and morphological parameters of pulmonary immaturity in rats that had severe CDH. Somatic and pulmonary growth were inhibited with high doses of dexamethasone. In the present study, we examined the effects of antenatal low-dose dexamethasone and thyrotropin-releasing hormone (TRH), alone or in combination, on the pulmonary maturation in CDH. Combined antenatal low-dose dexamethasone and TRH significantly reduced mean lung glycogen concentration (P = .001), and increased mean disaturated phosphatidylcholine content (P < .005) to better than that observed with either therapy alone, without changing mean body or lung weight. Combined TRH and low-dose glucocorticoid as an antenatal therapy may reduce the morbidity and mortality of CDH.


J Pediatr Surg


Suen HC,Losty P,Donahoe PK,Schnitzer JJ




Has Abstract


1994-02-01 00:00:00














  • Wide gap esophageal atresia: a new method to elongate the upper pouch.

    abstract::A new surgical method is presented for overbridging wide gap esophageal atresia. The method is based on the fact that the atretic upper pouch has an excellent longitudinal blood supply, and is two to three times wider than the lower pouch. Muco-muscular flap is created, which is anastomosed to the lower esophagus. ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Bar-Maor JA,Shoshany G,Sweed Y

    更新日期:1989-09-01 00:00:00

  • Idiopathic small bowel diaphragm disease identified by laparoscopic-assisted double-balloon enteroscopy in a child: an integrated successful definitive therapeutic method.

    abstract::In adults, small bowel diaphragm disease is a rare complication of small bowel enteropathy secondary to the use of nonsteroidal antiinflammatory drugs. The main clinical manifestations are gastrointestinal bleeding and subacute obstruction, and management can be challenging. We present a case of a 5-year-old girl with...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Soccorso G,Sarkhy A,Lindley RM,Marven SS,Thomson M

    更新日期:2012-08-01 00:00:00

  • Abdominal wall defect with liver appendage.

    abstract::We present an unusual case in which an appendage of the liver was the only herniated organ through a small defect on the left lower quadrant of the abdominal wall. To our knowledge this is the first case reported with this malformation. ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Fernandes ET,Hixson SD,Custer MD

    更新日期:1989-11-01 00:00:00

  • Abdominothoracic gastric teratoma in a female newborn infant.

    abstract::Gastric teratoma is a rare, benign tumor. The 47th case, reported here, is the first in which an abdominothoracic localization has been found. ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Esposito G,Cigliano B,Paludetto R

    更新日期:1983-06-01 00:00:00

  • Early operation in children with pancreas transection.

    abstract:BACKGROUND/PURPOSE:The preferred treatment for children with major pancreatic ductal injury remains controversial. This report compares our results using early operation with previously reported series using both operative and nonoperative management. METHODS:This is a retrospective analysis of all children with pancr...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Meier DE,Coln CD,Hicks BA,Guzzetta PC

    更新日期:2001-02-01 00:00:00

  • Identical twins with malrotation and type IV jejunal atresia.

    abstract::Identical twins are reported, who associated with maternal anaphylactic shock at 101/2 weeks gestation, acquired a type IV jejunal atresia with total absorption of the small bowel beyond the third portion of the duodenum and persistence of the most terminal length of ileum in the ileocolic artery in an apple peel conf...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Olson LM,Flom LS,Kierney CM,Shermeta DW

    更新日期:1987-11-01 00:00:00

  • Bronchomegaly as a complication of fetal endoscopic tracheal occlusion. A caution and a possible solution.

    abstract::Fetal medicine is developing rapidly and aims to improve the outcome for fetuses with congenital anomalies. Fetal endoscopic tracheal occlusion (FETO) has been developed for fetuses with congenital diaphragmatic hernia to counterbalance the compression of the lung by the abdominal viscera, preserving the pulmonary mat...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Speggiorin S,Fierens A,McHugh K,Roebuck DJ,McLaren CA,Mok Q,Broadhead M,Elliott MJ

    更新日期:2011-05-01 00:00:00

  • Serial transverse enteroplasty as primary therapy for neonates with proximal jejunal atresia.

    abstract::Small bowel atresia is associated with a large size discrepancy between the proximal and distal segments of bowel that has traditionally been managed by resection of the dilated segment, tapering enteroplasty, or plication. Longitudinal intestinal lengthening is rarely performed at the time of the initial operation. M...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Wales PW,Dutta S

    更新日期:2005-03-01 00:00:00

  • Sacrococcygeal teratoma: A population-based study of incidence and prenatal prognostic factors.

    abstract:BACKGROUND:Sacrococcygeal teratoma (SCT) is a rare congenital tumor associated with high rates of perinatal mortality and morbidity. This study evaluated the incidence, prenatal detection rate, and early predictors of a complicated outcome following diagnosis of SCT. METHODS:We retrospectively identified all fetuses a...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Hambraeus M,Arnbjörnsson E,Börjesson A,Salvesen K,Hagander L

    更新日期:2016-03-01 00:00:00

  • Management of a giant omphalocele with an external skin closure system.

    abstract:BACKGROUND/PURPOSE:The management of neonates with giant omphalocele remains challenging and multiple strategies have been described. We present the case of a 34-week-old neonate with isolated giant omphalocele managed with an external surgical skin closure system as a component of a staged closure strategy. CASE PRES...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Baird R,Gholoum S,Laberge JM,Puligandla P

    更新日期:2010-07-01 00:00:00

  • Anaphylactic shock due to rupture of a hepatic hydatid cyst into a pericystic blood vessel following blunt abdominal trauma.

    abstract::Partial drainage of a hepatic hydatid cyst into a pericystic blood vessel caused anaphylactic shock following minimal blunt abdominal trauma in a child. A case report including diagnostic procedures and treatment is presented. ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Eyal I,Zveibil F,Stamler B

    更新日期:1991-02-01 00:00:00

  • A tale of 3 testes? A rare presentation of lipoblastoma with a novel karyotype.

    abstract::Lipoblastoma is a rare benign mesenchymal tumor of embryonal fat that occurs almost exclusively in infants and children. Although lipoblastomas can affect any part of the body, only 5 cases affecting the scrotum have previously been reported. We present a case of an intrascrotal lipoblastoma with a novel karyotype. ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Robb A,Rogers T,Nicholls G

    更新日期:2010-01-01 00:00:00

  • Long-term results of intestinal transplantation for pseudo-obstruction in children.

    abstract:PURPOSE:The aim of this study was to determine long-term results of intestinal transplantation in children with pseudo-obstruction, particularly when stomach and colon are not part of the allograft. METHODS:The authors conducted a case-record review of all children who underwent transplantation at our center for a pri...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Iyer K,Kaufman S,Sudan D,Horslen S,Shaw B,Fox I,Langnas A

    更新日期:2001-01-01 00:00:00

  • Vascular ring: Early and long-term mortality and morbidity after surgical repair.

    abstract:BACKGROUND:Vascular ring is a rare cause of recurrent respiratory infections, dysphagia and stridor. Surgical repair is considered safe but the long-term outcomes are unclear. The purpose of this study was to investigate the mortality and morbidity following vascular ring surgery in a single institution. MATERIALS AND...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Schmidt AMS,Larsen SH,Hjortdal VE

    更新日期:2018-10-01 00:00:00

  • Conjoined twins--past, present, and future.

    abstract:BACKGROUND/PURPOSE:Conjoined twins are rare and complex anomalies of the newborn. They require a highly experienced team and a center equipped to deal with such challenging anatomy. METHOD:A review of 31 sets of conjoined twins was managed by one team over a 15-year period. The spectrum of the anomalies, management st...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Al Rabeeah A

    更新日期:2006-05-01 00:00:00

  • Congenital heart disease and heterotaxy: upper gastrointestinal fluoroscopy can be misleading and surgery in an asymptomatic patient is not beneficial.

    abstract:PURPOSE:Heterotaxy syndrome is associated with intestinal abnormalities. We sought to define the gastrointestinal anatomy and determine both the risk of volvulus and benefit of screening upper gastrointestinal fluoroscopy (UGI) in these patients. METHODS:Medical records from 2003 until 2011 at Children's Hospital Los ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Papillon S,Goodhue CJ,Zmora O,Sharma SS,Wells WJ,Ford HR,Upperman JS,Wang KS,Bushman GA,Kim R,Pierce JR

    更新日期:2013-01-01 00:00:00

  • Captopril reduces the severity of bowel damage in a neonatal rat model of necrotizing enterocolitis.

    abstract:BACKGROUND/PURPOSE:Selective mesenteric ischemia may result from activation of the renin-angiotensin system during periods of shock and is implicated in the pathogenesis of neonatal necrotizing enterocolitis (NEC). We investigated the effectiveness of captopril, an angiotensin-converting enzyme inhibitor, in reducing t...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Zani A,Eaton S,Leon FF,Malerba A,Hall NJ,De Coppi P,Smith VV,Pierro A

    更新日期:2008-02-01 00:00:00

  • An experimental study on the pathogenesis of gastroesophageal reflux after repair of diaphragmatic hernia.

    abstract:BACKGROUND/PURPOSE:Gastroesophageal reflux (GER) is increasingly reported after surgical repair of congenital diaphragmatic hernia (CDH) and eventration. The aim of this study was to test the hypothesis that transdiaphragmatic pressure gradients are increased and that the antireflux barrier is weakened after plication ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Qi B,Soto C,Diez-Pardo JA,Tovar JA

    更新日期:1997-09-01 00:00:00

  • Preoperative embolization as an adjunct to the operative management of mediastinal Castleman disease.

    abstract::Castleman disease usually presents in children as a localized mass with prominent feeding vessels. The mainstay of treatment of Castleman disease is surgical resection; historically, resection is associated with excessive blood loss. These tumors are well known to have large feeding vessels and, thus, are amenable to ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Safford SD,Lagoo AS,Mahaffey SA

    更新日期:2003-09-01 00:00:00

  • Nasal glioma.

    abstract::In this report 12 cases of nasal glioma are reviewed. It is shown that they present in three different ways. The etiology, pathology, differential diagnosis, and treatment are discussed. ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Alexander TA

    更新日期:1978-10-01 00:00:00

  • Pathophysiology of congenital diaphragmatic hernia. XVI: Elevated pulmonary collagen in the lamb model of congenital diaphragmatic hernia.

    abstract::The pathophysiologic features of congenital diaphragmatic hernia (CDH) include pulmonary hypoplasia, pulmonary hypertension, surfactant deficiency, and decreased pulmonary compliance. When the surfactant deficiency is corrected using exogenous surfactant therapy, the pulmonary compliance improves, but does not reach n...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Hassett MJ,Glick PL,Karamanoukian HL,Rossman JE,Wilcox DT,Azizkhan RG

    更新日期:1995-08-01 00:00:00

  • Early fetal obstructive uropathy produces Potter's syndrome in the lamb.

    abstract:BACKGROUND:If creating an obstructive uropathy early in glomerulogenesis produces MCDK (Multicystic Dysplastic Kidney), then a very early obstruction may produce Potter's Syndrome (PS) with oligohydramnios. METHODS:Fetal lambs at 50 days' gestation underwent urethral and urachal ligation using fine SILASTIC (Dow Corni...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Kitagawa H,Pringle KC,Zucollo J,Koike J,Nakada K,Moriya H,Seki Y

    更新日期:2000-11-01 00:00:00

  • Blocking of endogenous nitric oxide increases white blood cell accumulation in rat lung.

    abstract:BACKGROUND/PURPOSE:Nitric oxide (NO) is a known selective dilator of the pulmonary vascular tree. There also is evidence that it plays a role in diminishing neutrophil adherence to vascular endothelial cells. An understanding of these effects of NO on the pulmonary microcirculation is essential to our understanding of ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Roman A,Legallo R,McGahren ED

    更新日期:2004-01-01 00:00:00

  • Presentations beyond the matrix: The Fred MacLeod JPS lecture, CAPS 2019.

    abstract::Current research calculates the time between development of new evidence-based knowledge into established clinical practice as 17 years. This is the knowledge translation gap. The factors influencing this delay are multiple, but it is clear across the history of medicine that knowledge from new, well-constructed studi...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,评审


    authors: Fisher R

    更新日期:2020-05-01 00:00:00

  • Successful surgical treatment of two cases of congenital chylous ascites.

    abstract::The authors report on 2 patients with congenital chylous ascites who underwent successful lymphatic duct ligation after a laparoscopic lymphoid dye test. Fetal ascites had been detected in both cases, and both babies were born with marked abdominal swelling. Given that conservative treatment by medium-chain triglyceri...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Mitsunaga T,Yoshida H,Iwai J,Matsunaga T,Kouchi K,Ohtsuka Y,Okada T,Hishiki T,Ohnuma N

    更新日期:2001-11-01 00:00:00

  • Diffuse cavernous hemangioma of the rectosigmoid and low anterior resection using the autostapler.

    abstract::Over 200 cases of colonic hemangioma have been reported, with more than 50% occurring in the rectosigmoid. These benign vascular neoplasms usually present in childhood, often with life-threatening hemorrhage. Lack of awareness of the condition continues to lead to errors in diagnosis and management, and may contribute...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Corbally MT,McMullin JP

    更新日期:1988-11-01 00:00:00

  • Diagnostic accuracy of serum alpha-fetoprotein levels in diagnosing recurrent sacrococcygeal teratoma: A systematic review.

    abstract:BACKGROUND:The incidence of children developing recurrent sacrococcygeal teratoma (SCT) is 2-35%. Serum alpha-fetoprotein (AFP) is often used as a tumor marker for (malignant) recurrences of SCT and could potentially be used during routine follow-up after SCT resection. However, the diagnostic accuracy of serum AFP lev...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: van Heurn LJ,Knipscheer MM,Derikx JPM,van Heurn LWE

    更新日期:2020-09-01 00:00:00

  • Hepatic artery transection after blunt trauma: case presentation and review of the literature.

    abstract::Hepatic artery injuries sustained as a result of blunt abdominal trauma are rare. This case represents the first reported hepatic artery transection and the second hepatic artery injury described in children. Hepatic artery injuries are associated with high mortality, and their management is complex and controversial....

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,评审


    authors: Miglietta MA,Moore JA,Bernstein MP,Frangos SG,Ginsburg H,Pachter HL

    更新日期:2006-09-01 00:00:00

  • Comparison of operative outcomes between surgical gastrostomy and percutaneous endoscopic gastrostomy in infants.

    abstract:PURPOSE:Safety profile of different gastrostomy procedures in small children has not been well studied. This study was conducted to investigate whether complication and mortality rates differ between surgical gastrostomy (G-tube) and percutaneous endoscopic gastrostomy (PEG) in infants and neonates. METHODS:In this re...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Miyata S,Dong F,Lebedevskiy O,Park H,Nguyen N

    更新日期:2017-09-01 00:00:00

  • American pediatric surgical association journal of pediatric surgery lecture.

    abstract::Every year in the United States, 1.6 to 3.8 million concussions occur secondary to injuries sustained during sports and recreational activities. Major advances have been made in terms of identifying specific clinical profiles following concussion. Nevertheless, there are continued misunderstandings regarding this inju...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Collins MW,Womble MN

    更新日期:2017-01-01 00:00:00