Abstract:
:The two major modalities of pharmacomechanical coupling, inositol 1,4,5, trisphosphate induced Ca2+ release and modulation of Ca(2+)-sensitivity, are reviewed. Recent studies show that although changes in cytoplasmic Ca2+ play the major role in regulating smooth muscle contraction, agonists can also significantly affect the contractile state by modifying Ca(2+)-sensitivity. Inhibition of myosin light chain kinase or myosin light chain phosphatase leads to, respectively, desensitization or sensitization of the contractile apparatus to Ca2+. G-protein linked inhibition of myosin light chain phosphatase and Ca2+ release mediated by the phosphatidylinol cascade are the two major pharmacomechanical coupling mechanisms.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Somlyo AV,Somlyo APdoi
10.1007/978-1-4615-2946-0_4subject
Has Abstractpub_date
1993-01-01 00:00:00pages
31-8eissn
0065-2598issn
2214-8019journal_volume
346pub_type
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