Abstract:
:Malignant obstructive jaundice is associated with poor aerobic capacity. We measured oxygen consumption and oxygen extraction (arterial-venous oxygen content) in the legs of nine patients during cardiopulmonary exercise testing before pancreaticoduodenectomy. The median (IQR [range]) peak oxygen consumption was 67 (49-77 [32-84])% of predicted. Normal patterns of oxygen extraction were seen with increasing power towards lactate threshold. Near maximal oxygen extraction occurred at peak exercise. Femoral venous oxygen pressure and saturation exceeded baseline values whilst recovering from exercise. These findings suggest that peripheral oxygen extraction is normal during exercise in patients with malignant obstructive jaundice. The primary limitation in oxygen consumption is reduced oxygen delivery.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Junejo MA,Siriwardena AK,Parker MJdoi
10.1111/anae.12478subject
Has Abstractpub_date
2014-01-01 00:00:00pages
32-6issue
1eissn
0003-2409issn
1365-2044journal_volume
69pub_type
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