Abstract:
:Eighty-seven per cent of surgical patients receiving undiluted diazepam experienced pain on injection while 6-16%, depending on the dose, manifested evidence of clinical thrombophlebitis. This was improved when diazepam, 10 mg, was diluted to 20-40 ml with intravenous solution. In contrast, lorazepam appeared to have minimal irritative or injurious effects on veins whether undiluted or diluted. In view of these results and clinical studies reporting a higher patient acceptance of lorazepam than diazepam, lorazepam may be a superior drug for use in anaesthesia.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Graham CW,Pagano RR,Conner JTdoi
10.1111/j.1365-2044.1978.tb08348.xsubject
Has Abstractpub_date
1978-02-01 00:00:00pages
188-91issue
2eissn
0003-2409issn
1365-2044journal_volume
33pub_type
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