Pain and clinical thrombophlebitis following intravenous diazepam and lorazepam.

Abstract:

:Eighty-seven per cent of surgical patients receiving undiluted diazepam experienced pain on injection while 6-16%, depending on the dose, manifested evidence of clinical thrombophlebitis. This was improved when diazepam, 10 mg, was diluted to 20-40 ml with intravenous solution. In contrast, lorazepam appeared to have minimal irritative or injurious effects on veins whether undiluted or diluted. In view of these results and clinical studies reporting a higher patient acceptance of lorazepam than diazepam, lorazepam may be a superior drug for use in anaesthesia.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Graham CW,Pagano RR,Conner JT

doi

10.1111/j.1365-2044.1978.tb08348.x

subject

Has Abstract

pub_date

1978-02-01 00:00:00

pages

188-91

issue

2

eissn

0003-2409

issn

1365-2044

journal_volume

33

pub_type

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