The effect of a novel intravenous fluid (Oxsealife®) on recovery from haemorrhagic shock in pigs.

Abstract:

:Blood transfusion is given according to haemoglobin thresholds aimed at restoration of arterial oxygen-carrying capacity. Patient survival after severe haemorrhagic shock depends on restoration of microvascular perfusion, tissue oxygen delivery, endothelial function and organ integrity. We investigated a novel crystalloid fluid designed for tissue oxygen delivery, Oxsealife® , with components that generate microvascular nitric oxide and scavenge reactive oxygen species generated during ischaemia-reperfusion injury. The amount of dissolved oxygen in blood progressively increased during step-wise in vitro haemodilution with this fluid, suggesting that the oxygen solubility coefficient of blood is dynamic, not static. We performed a pilot safety and efficacy study to compare resuscitation with this novel crystalloid vs. whole blood transfusion in a swine haemorrhagic shock model with animals bled to an arterial lactate oxygen debt target. Despite contributing no haemoglobin, viscosity nor oncotic potential, resuscitation with Oxsealife after severe haemorrhagic shock restored central haemodynamic parameters comparable to stored allogeneic blood transfusion. Tissue perfusion, oxygenation and metabolic outcomes were equivalent between treatment groups. Increased consumption of bicarbonate in animals given Oxsealife suggested greater capillary recruitment and enhanced clearance of acidic tissue metabolites. Serum markers of organ function, animal activity during recovery and histological analysis of tissue morphology and endothelial glycocalyx integrity confirmed functional recovery from haemorrhagic shock. We conclude that recovery of tissue oxygen delivery and organ function after haemorrhagic shock may not be dependent on treatments that increase haemoglobin levels. Oxsealife shows promise for treatment of severe haemorrhagic shock and may reduce the requirement for allogeneic blood products.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Oller L,Dyer WB,Santamaría L,Largo C,Javidroozi M,Shander A

doi

10.1111/anae.14627

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

765-777

issue

6

eissn

0003-2409

issn

1365-2044

journal_volume

74

pub_type

杂志文章
  • Air inlets for infusion bottles.

    abstract::We assessed the resistance to air flow in four commonly used air inlets. The Avon A81 and Codan air inlets provide the least resistance to flow, followed by the Baxter CO413 and lastly the Braun air inlet. The presence of a valve confers an advantage when rapid infusion of fluid is attempted. The valve in the Codan ai...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1994.tb14233.x

    authors: Thorpe CM,Scott DH

    更新日期:1994-07-01 00:00:00

  • A randomised controlled trial of placebo, droperidol or ondansetron to prevent nausea and vomiting after tonsillectomy in children receiving dexamethasone.

    abstract::We tested whether prophylactic droperidol and ondansetron, in combination with a moderate dose of dexamethasone, were equally effective in reducing nausea and vomiting after tonsillectomy in children and that both were superior to saline with dexamethasone. We randomly allocated 300 children to intravenous saline, dro...

    journal_title:Anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/anae.13907

    authors: Flubacher P,Fournier N,Cherpillod J,Waridel F,Nydegger M,Albrecht E

    更新日期:2017-07-01 00:00:00

  • Postoperative analgesia using papaveretum and orphenadrine. A preliminary trial.

    abstract::The action of orphenadrine when given towards the end of a general anaesthetic is described. It is shown to delay the need for postoperative analgesia and extend the analgesic action of papaveretum. ...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1979.tb06311.x

    authors: Fry EN

    更新日期:1979-03-01 00:00:00

  • SHO training in anaesthetics. How good is it?

    abstract::All senior house officer posts in the Yorkshire Deanery have been assessed against five parameters. Posts in anaesthesia were among the best with excellent consultant support, good exposure to clinical practice and well-structured education and training. Anaesthetic posts were almost unique in satisfying the 'New Deal...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1998.00245.x

    authors: Bunch GA,Bahrami J,Macdonald R

    更新日期:1998-01-01 00:00:00

  • Use of a low-power nerve stimulator during sciatic nerve block.

    abstract::The use of a low-power nerve stimulator to aid nerve location during the performance of sciatic nerve block was compared with a conventional anatomically based technique. The success rate, both in terms of the production of an effective block and the duration of postoperative analgesia, was significantly higher in the...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1987.tb03043.x

    authors: Smith BE,Allison A

    更新日期:1987-03-01 00:00:00

  • Predictors of postoperative myocardial ischaemia. The role of intercurrent arterial hypertension and other cardiovascular risk factors.

    abstract::One hundred and eighty-three patients were studied to examine the role of a number of risk factors in the development of silent ischaemia after general anaesthesia for general and vascular surgery. We collected evidence of cardiovascular risk factors using a binary questionnaire. The patients were monitored pre- and p...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1997.29-az029.x

    authors: Howell SJ,Hemming AE,Allman KG,Glover L,Sear JW,Foëx P

    更新日期:1997-02-01 00:00:00

  • Harold King. A notable contributor to anaesthesia.

    abstract::Harold King was an analytical chemist of distinction, who worked with Sir Henry Dale and his colleagues in the Medical Research Institute, later the Medical Research Council. He helped to quash the theory that the anaesthetic action of ether was attributable to its impurities. Interest in alkaloids led to the elucidat...

    journal_title:Anaesthesia

    pub_type: 传,历史文章,杂志文章

    doi:10.1111/j.1365-2044.1991.tb09723.x

    authors: Gray TC

    更新日期:1991-08-01 00:00:00

  • A thermographic study of paravertebral analgesia.

    abstract::Six patients undergoing paravertebral blocks for chronically painful conditions of the chest wall were thermographically imaged so that the extent of cutaneous vasodilatation and hence sympathetic block could be correlated with the distribution of the somatic block. All blocks were performed by a single experienced op...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1995.tb15092.x

    authors: Cheema SP,Ilsley D,Richardson J,Sabanathan S

    更新日期:1995-02-01 00:00:00

  • An anti-pollution modification for the Cape-Waine anaesthetic ventilator.

    abstract::Most anaesthetic equipment needs to be modified to fulfil anti-pollution recommendations. A method of modifying a Cape-Waine Anaesthetic Ventilator is described in detail showing what parts need to be replaced or removed. A list of the new parts required together with their cost is given and the modification can be ma...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1977.tb09968.x

    authors: Zorab JS,Fox DE

    更新日期:1977-11-01 00:00:00

  • Prevention of propofol-induced injection pain by remifentanil: a placebo-controlled comparison with lidocaine.

    abstract::In a randomised, double-blind study we compared the efficacy of continuous remifentanil infusion (0.25 microg x kg(-1) x min(-1) with 40 mg lidocaine and placebo in the prevention of injection pain due to intravenous propofol administration (1.5-2 mg x kg(-1)) in 155 patients scheduled for elective surgery. Pain sever...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验,收录出版

    doi:10.1046/j.1365-2044.2003.02964_2.x

    authors: Roehm KD,Piper SN,Maleck WH,Boldt J

    更新日期:2003-02-01 00:00:00

  • The development of apparatus for intermittent negative pressure respiration. (2) 1919-1976, with special reference to the development and uses of cuirass respirators.

    abstract::This paper and the one that preceded it1 have traced the development of the design and use of negative pressure ventilators from their origins in the early nineteenth century to the present day. Their maximum use was in the nineteen-forties and the early fifties after which they were quite rapidly replaced in the trea...

    journal_title:Anaesthesia

    pub_type: 历史文章,杂志文章

    doi:10.1111/j.1365-2044.1976.tb11849.x

    authors: Woollam CH

    更新日期:1976-06-01 00:00:00

  • Pressure support ventilation during isoflurane anaesthesia.

    abstract::We have studied the respiratory effects of 5 and 10 cmH2O pressure support ventilation during anaesthesia with 1.5% end-tidal concentration of isoflurane in nine healthy, spontaneously breathing, adult patients. Some of the patients demonstrated an irregular respiratory pattern with periods of apnoea and we therefore ...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1995.tb05944.x

    authors: Bhatt SB,Chui PT,Gin T,Tam YH,Oh TE

    更新日期:1995-12-01 00:00:00

  • Treatment of acute total atelectasis. Use of a double lumen tube.

    abstract::Three cases are described of complete collapse of a lung in the absence of bronchial obstruction. The condition was treated by the application of a sustained high pressure (6 kPa) to the affected lung through one limb of a double lumen bronchial tube whilst intermittent positive pressure ventilation was continued thro...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1985.tb10707.x

    authors: Murray JF

    更新日期:1985-02-01 00:00:00

  • Comparison of extradural and intravenous diamorphine as a supplement to extradural bupivacaine.

    abstract::The influence of route of administration (extradural as compared with intravenous) of diamorphine 0.5 mg/hour as a supplement to extradural bupivacaine (0.125% at 15 ml/hour) was investigated in two groups of 20 patients who underwent major abdominal gynaecological surgery. Significantly more patients in the intraveno...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1991.tb11680.x

    authors: Lee A,McKeown D,Brockway M,Bannister J,Wildsmith JA

    更新日期:1991-06-01 00:00:00

  • Peri-operative administration of tranexamic acid in lower limb arthroplasty: a multicentre, prospective cohort study.

    abstract::In the UK, tranexamic acid is recommended for all surgical procedures where expected blood loss exceeds 500 ml. However, the optimal dose, route and timing of administration are not known. This study aimed to evaluate current practice of peri-operative tranexamic acid administration. Patients undergoing primary total ...

    journal_title:Anaesthesia

    pub_type: 杂志文章,多中心研究

    doi:10.1111/anae.15056

    authors: Lloyd TD,Neal-Smith G,Fennelly J,Claireaux H,Bretherton C,Carr AJ,Murphy M,Kendrick BJ,Palmer AJR,collaborators.

    更新日期:2020-08-01 00:00:00

  • Viral gastroenteritis--a danger to the patient, a danger to the staff.

    abstract::Viral gastroenteritis is usually a mild, self-limiting illness. We report a case of a previously well 74-year-old woman who suffered a grave complication of this common condition, and caused a significant outbreak of illness amongst staff involved in her care. This case highlights the risks of Hospital Acquired Infect...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.2003.03621.x

    authors: Appelboam R,Hammond E

    更新日期:2004-03-01 00:00:00

  • Partner anxiety prior to elective Caesarean section under regional anaesthesia.

    abstract::This study was designed to measure anxiety levels in 91 partners of women undergoing elective Caesarean section under regional anaesthesia and to outline potential relieving factors. Twenty-eight percent of partners were pathologically anxious. There was a positive association between anxiety and prior attendance at t...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1046/j.1365-2044.2002.02509_5.x

    authors: Taylor IR,Bullough AS,van Hamel JC,Campbell DN

    更新日期:2002-06-01 00:00:00

  • The variable effect of low-dose volatile anaesthetics on the acute ventilatory response to hypoxia in humans: a quantitative review.

    abstract::The purpose of this study was to review published studies (identified by a Medline-assisted search) on the effect of < or = 0.2 minimal alveolar concentration (MAC) halothane, isoflurane, enflurane and sevoflurane on the acute hypoxic ventilatory response in healthy subjects. Each article was examined for the anaesthe...

    journal_title:Anaesthesia

    pub_type: 杂志文章,meta分析,评审

    doi:10.1046/j.1365-2044.2002.02604.x

    authors: Pandit JJ

    更新日期:2002-07-01 00:00:00

  • Malignant hyperthermia susceptibility. Management during pregnancy and labour.

    abstract::A case of pregnancy complicated by malignant hyperthermia susceptibility is reported. Serum CPK and electrolyte concentrations were measured during pregnancy and labour. Labour and delivery were managed successfully under epidural analgesia using plain bupivacaine 0.5%. ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1979.tb04865.x

    authors: Willatts SM

    更新日期:1979-01-01 00:00:00

  • Rational planning of operating lists: a prospective comparison of 'booking to the mean' vs. 'probabilistic case scheduling' in urology.

    abstract::The efficient use of operating theatres requires accurate case scheduling. One common method is 'booking to the mean'. Here, the mean times for individual operations are summed to approximate the time allocated to the list. An alternative approach is 'probabilistic scheduling'. Here, the means and standard deviation o...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/anae.14958

    authors: Pandit JJ

    更新日期:2020-05-01 00:00:00

  • Anaesthesia and demyelinating disease.

    abstract::The demyelinating diseases are classified and the current concepts of the aetiology and pathophysiology of the most common of these diseases, multiple sclerosis, are described. The effects of the impaired function, local responses and known complications of the disease on the choice of anaesthetic, drugs and technique...

    journal_title:Anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2044.1980.tb03947.x

    authors: Jones RM,Healy TE

    更新日期:1980-09-01 00:00:00

  • Cor pulmonale and the Pierre Robin anomaly. Airway management with a nasopharyngeal tube.

    abstract::An infant with Pierre Robin anomaly was anaesthetised for cardiac catheterisation. There was cor pulmonale with the pulmonary artery pressure at systemic level, a patent foramen ovale and a persistent ductus arteriosus. The effects of alterations in blood gases on the haemodynamics and intracardiac shunts are consider...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1980.tb05097.x

    authors: Freeman MK,Manners JM

    更新日期:1980-03-01 00:00:00

  • Ropivacaine in ultrasound-guided femoral nerve block: what is the minimal effective anaesthetic concentration (EC90)?

    abstract::The objective of this study was to estimate the minimal effective anaesthetic concentrations of ropivacaine required to block the femoral nerve in 90% of patients. Forty-five patients who had knee surgery received ultrasound-guided femoral nerve block using 15 ml ropivacaine. The ropivacaine concentration given to a p...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/anae.12607

    authors: Taha AM,Abd-Elmaksoud AM

    更新日期:2014-07-01 00:00:00

  • Influence of ketanserin pretreatment on the haemodynamic responses to sternotomy.

    abstract::The effect of intravenous ketanserin on the pressor response to sternotomy was studied in 36 patients undergoing coronary artery surgery. Two doses of the drug (10 mg and 20 mg) were compared with a placebo injection of saline. After induction of anaesthesia, haemodynamic variables were measured until the institution ...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1986.tb13275.x

    authors: Cashman JN,Thompson MA,Bennett A

    更新日期:1986-05-01 00:00:00

  • Breast feeding and anaesthesia.

    abstract::Anaesthetists require a good knowledge of the excretion of drugs in breast milk and the potential hazards to suckling infants of drug ingestion via breast milk. A brief account of the physiology of lactation is given. The mechanisms of drug passage into breast milk are discussed followed by a review of the excretion i...

    journal_title:Anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2044.1993.tb07130.x

    authors: Lee JJ,Rubin AP

    更新日期:1993-07-01 00:00:00

  • Vecuronium--a variable dose technique.

    abstract::Vecuronium was administered to patients in doses of 100, 150, 200 and 250 micrograms/kg and the duration of action recorded by noting the time to recovery of the first twitch in a train-of-four to 10% of the control twitch. The recovery times ranged from a mean of 28.4 minutes (100 micrograms/kg) to 72.4 minutes (250 ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1987.tb03000.x

    authors: Feldman SA,Liban JB

    更新日期:1987-02-01 00:00:00

  • Propofol sedation after open heart surgery. A clinical and pharmacokinetic study.

    abstract::One hundred adult patients who required mechanical ventilation after open heart surgery for coronary revascularisation were studied. All received a standard premedication and a high dose opioid anaesthetic. On arrival in the intensive care unit they were allocated randomly to receive either propofol or midazolam to ma...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1990.tb14743.x

    authors: McMurray TJ,Collier PS,Carson IW,Lyons SM,Elliott P

    更新日期:1990-04-01 00:00:00

  • Effect of sufentanil on intracranial pressure in neurosurgical patients.

    abstract::The effects of sufentanil on intracranial pressure, mean arterial pressure, cerebral perfusion pressure and heart rate were studied in 20 neurosurgical intensive care unit patients. Epidural intracranial pressure probes were implanted in patients who suffered head injury, intracerebral haemorrhage or underwent tumour ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1991.tb09596.x

    authors: Weinstabl C,Mayer N,Richling B,Czech T,Spiss CK

    更新日期:1991-10-01 00:00:00

  • Subcutaneous tissue oxygen tension after coronary revascularisation with and without cardiopulmonary bypass.

    abstract::Directly measured subcutaneous tissue oxygen tension reflects the adequacy of regional tissue oxygenation and influences wound infection and healing. We tested the hypothesis that off-pump coronary artery bypass would increase subcutaneous tissue oxygen tension by minimizing cardiopulmonary bypass-induced systemic inf...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.2004.03608.x

    authors: Cody C,Buggy DJ,Marsh B,Moriarity DC

    更新日期:2004-03-01 00:00:00

  • Nitrous oxide sedation in dentistry. A comparison between Rotameter settings, pharyngeal concentrations and blood levels of nitrous oxide.

    abstract::Nitrous oxide concentrations (V/V) at the delivery Rotameters block, nasal mask, pharynx and venous blood, were compared. There was a dilution of approximately 50% of the delivered nitrous oxide at the nasal mask which was further reduced in the pharynx. Venous blood concentrations 10 minutes after inhalation of nitro...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1984.tb07233.x

    authors: Sher AM,Braude BM,Cleaton-Jones PE,Moyes DG,Mallett J

    更新日期:1984-03-01 00:00:00