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Sodium tanshinone IIA sulfonate inhibits porcine reproductive and respiratory syndrome virus via suppressing N gene expression and blocking virus-induced apoptosis.

Abstract：

BACKGROUND:Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant economic loss in the swine industry. Currently, there is no effective way to prevent PRRSV infection. Sodium tanshinone IIA sulfonate (STS), a natural compound derived from Salvia miltiorrhiza, was shown to possess anti-PRRSV activity, but the underlying mechanisms remain unclear. The objective of this study was to investigate the effect of STS on PRRSV-induced cell apoptosis and PRRSV N protein expression pattern. METHODS:Relative quantification real-time PCR was used to evaluate the inhibition of STS on N gene expression. Simultaneously indirect immunofluorescence assay (IFA) and western blot were used to assess the effect on N protein expression. Apoptosis was analysed using fluorescence microscope with an annexin V-EGFP kit. The effect of STS on caspase-3 cleaving was assessed by western blot. RESULTS:Our results showed that STS could inhibit viral N gene expression at both the messenger RNA stage and at the protein level in PRRSV-infected cells in a dose-dependent manner. In addition, STS could also rescue PRRSV-induced apoptosis. CONCLUSIONS:Our data suggest that STS may serve as a base compound for developing more effective drugs against PRRSV infection.

journal_name

Antivir Ther

journal_title

Antiviral therapy

authors

Sun N,Li E,Wang Z,Zhao J,Wang S,He J,Bai Y,Li H

doi

10.3851/IMP2694

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

89-95

issue

1

eissn

1359-6535

issn

2040-2058

journal_volume

19

pub_type

杂志文章

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