Abstract：
BACKGROUND:Acute exacerbation (AE) in chronic hepatitis B (CHB) is usually followed by a spontaneous decline in HBV DNA levels. The subsequent treatment is controversial. In this study, we evaluated the efficacy and safety of pegylated interferon-α2a (PEG-IFN-α2a) for such CHB patients. METHODS:A total of 74 hepatitis B e antigen (HBeAg)-positive patients with a spontaneous HBV DNA decline (by >2 log10 IU•ml(-1), compared with baseline levels before antiviral treatment) after AE (alanine aminotransferase [ALT]: 10-30-fold the upper limit of normal [ULN], total bilirubin [TBIL]: 2-20 mg•dl(-1), prothrombin time activity >60%) were included. In total, 22 patients (group A) received PEG-IFN-α2a treatment (180 µg•kg(-1)•week(-1), when ALT was <10 ULN and TBIL<2 mg•dl(-1)) for 48 weeks, with 48 weeks of treatment-free follow-up. Twenty-one patients (group B) selected continual entecavir therapy. Thirty-one patients (group C, control group) received routine liver-protective drugs. RESULTS:At week 96, virological response rates were 90.5%, 100% and 48%, and ALT normalization rates were 81%, 95% and 40% for groups A, B and C, respectively. HBeAg seroconversion rates were 71.4%, 45% and 32% in groups A, B and C, respectively. A high hepatitis B surface antigen (HBsAg) loss rate was observed in PEG-IFN-α2a-treated patients, while no entecavir-treated patients achieved HBsAg loss. Group A patients suffered from typical PEG-IFN therapy-related adverse events. No severe adverse event was observed in any groups. CONCLUSIONS:PEG-IFN-α2a is effective and safe for treating CHB patients demonstrating a spontaneous decline in HBV DNA after AE, and yields an increased likelihood of HBsAg loss.
journal_name
Antivir Therjournal_title
Antiviral therapyauthors
Cai Q,Chen F,Shao X,Zhang X,Zhao Z,Gao Zdoi
10.3851/IMP2832subject
Has Abstractpub_date
2015-01-01 00:00:00pages
217-24issue
2eissn
1359-6535issn
2040-2058journal_volume
20pub_type
杂志文章abstract：BACKGROUND:No data are available on the clinical presentation and virological pattern in the case of failure of interferon (IFN)-free regimens in patients with genotype-3h. In this paper authors identified the virological and clinical characteristics of patients with genotype-3h treated with suboptimal or not indicated...
journal_title：Antiviral therapy
pub_type： 杂志文章
doi：10.3851/IMP3228
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:HIV-1 shedding in genital secretions is associated with HIV transmission risk. Limited data exist on the effect of second-line lopinavir/ritonavir monotherapy (mLPV/r) on genital secretion of HIV RNA. METHODS:We measured HIV-1 in genital secretions of HIV-infected adults at time of failure from non-nucleosi...
journal_title：Antiviral therapy
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：10.3851/IMP2722
更新日期：2014-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
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更新日期：2007-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
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更新日期：2019-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：
更新日期：1996-08-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：10.3851/IMP1470
更新日期：2009-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 临床试验,杂志文章
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更新日期：2006-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：
更新日期：2004-12-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章,评审
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更新日期：2001-09-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章,评审
doi：
更新日期：2008-01-01 00:00:00
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pub_type： 杂志文章,多中心研究
doi：
更新日期：2007-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：10.3851/IMP2335
更新日期：2012-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：
更新日期：2004-04-01 00:00:00
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pub_type： 评论,杂志文章
doi：10.3851/IMP2314
更新日期：2012-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章,评审
doi：
更新日期：1998-01-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2003-08-01 00:00:00
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journal_title：Antiviral therapy
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doi：
更新日期：1998-01-01 00:00:00
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pub_type： 杂志文章,随机对照试验
doi：
更新日期：2008-01-01 00:00:00
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更新日期：2009-01-01 00:00:00
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journal_title：Antiviral therapy
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doi：
更新日期：2008-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
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更新日期：2013-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2013-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
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更新日期：2010-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章,评审
doi：
更新日期：1997-07-01 00:00:00
