Abstract：
BACKGROUND:Cerebrospinal fluid (CSF) HIV RNA is commonly used as a marker of compartmental antiviral activity in HIV-positive patients. Undetectable CSF HIV RNA levels have been associated with low CSF neopterin levels and better neurocognitive performances. The aim of this study was to analyse the prevalence and predictors of non-detectable CSF HIV RNA using a commercial assay. METHODS:In adult HIV-positive HAART-treated patients with confirmed plasma HIV RNA <50 copies/ml, CSF HIV RNA (with Roche Amplicor Assay) and neopterin were measured. RESULTS:112 adult patients were included. Plasma and CSF HIV RNA were non-detectable (target not detected [TND]) in 29 (25.9%) and 36 (32.1%) patients, respectively. CSF TND was observed more frequently in patients with plasma TND (P=0.005, OR=3.87). CSF neopterin levels were associated with age (rho =0.333, P=0.002) and current (rho= -0.272, P=0.015) and nadir (rho =-0.240, P=0.038) CD4+ T-lymphocytes; the lowest CSF neopterin concentration was observed in patients with CSF TND versus other viral load strata (0.62 mg/dl versus 0.78 mg/dl; P=0.048). CONCLUSIONS:Efficaciously treated HIV-positive patients with detectable plasma HIV RNA might imperfectly control CSF viral replication. Prospective studies addressing the management and neurocognitive consequences of CSF low-level viraemia are warranted.
journal_name
Antivir Therjournal_title
Antiviral therapyauthors
Motta I,Allice T,Romito A,Ferrara M,Ecclesia S,Imperiale D,Ghisetti V,Di Perri G,Bonora S,Calcagno Adoi
10.3851/IMP3140subject
Has Abstractpub_date
2017-01-01 00:00:00pages
539-543issue
6eissn
1359-6535issn
2040-2058journal_volume
22pub_type
杂志文章abstract：BACKGROUND:Serum HBV RNA is detectable during nucleoside/nucleotide analogue therapy as a result of unaffected RNA replicative intermediates or interrupted reverse transcription. We studied the predictive value of serum HBV RNA for initial virological response during nucleoside analogue therapy. METHODS:Serum HBV RNA ...
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doi：
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journal_title：Antiviral therapy
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Antiviral therapy
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journal_title：Antiviral therapy
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更新日期：1999-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章,评审
doi：
更新日期：2001-01-01 00:00:00
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doi：
更新日期：2005-01-01 00:00:00
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更新日期：2014-01-01 00:00:00
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doi：
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journal_title：Antiviral therapy
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doi：
更新日期：2007-01-01 00:00:00
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doi：
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