Abstract：
OBJECTIVES:To characterize 1-year virological response to antiretroviral therapy and its determinants by sex. METHODS:This is a population-based analysis of antiretroviral therapy naive HIV-positive adult men and women. Factors associated with sex and with plasma HIV RNA viral load suppression to below 500 copies/ml were examined using non-parametric tests and logistic regression analyses. RESULTS:A total of 739 subjects (92 women and 647 men) were eligible. Female participants were younger (34 vs 37 years; P < 0.001), less likely to have AIDS (6.5 vs 14.4%; P = 0.039), more frequently injection drug users (44.6 vs 25.2%; P = 0.001) and were less likely to be adherent to therapy (34.8 vs 62.9%; P < 0.001) than male participants. There was no difference in baseline median CD4 count (P = 0.424) or HIV RNA levels (P = 0.140), physician experience (P = 0.057), or with respect to antiretroviral regimens containing protease inhibitors or non-nucleoside reverse transcriptase inhibitors (P = 0.911). With treatment, 46.7% (43/92) of women and 64.8% (419/647) of men (P = 0.001) suppressed HIV RNA viral load to below 500 copies/ml at 1 year. In a multivariate analysis, the association of sex with HIV RNA response to antiretroviral therapy fell from statistical significance (odds ratio 1.18; 95% CI: 0.72-1.95) after adjusting for adherence, injection drug use and age. CONCLUSION:Our data indicate that in this population-based setting, sex differences in 1-year virological response to antiretroviral therapy are explained by age, adherence and injection drug use.
journal_name
Antivir Therjournal_title
Antiviral therapyauthors
O'Connell JM,Braitstein P,Hogg RS,Yip B,Craib KJ,O'Shaughnessy MV,Montaner JS,Burdge DRsubject
Has Abstractpub_date
2003-12-01 00:00:00pages
569-76issue
6eissn
1359-6535issn
2040-2058journal_volume
8pub_type
杂志文章abstract：BACKGROUND:Pegylated interferon/ribavirin combination is currently the standard treatment for chronic hepatitis C virus (HCV) infection. Body weight adjustment of ribavirin is crucial for response. However, previous studies found no relation between ingested dose and plasma concentration. The aim of this study was to d...
journal_title：Antiviral therapy
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journal_title：Antiviral therapy
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journal_title：Antiviral therapy
pub_type： 杂志文章,评审
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：10.3851/IMP3344
更新日期：2019-01-01 00:00:00
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journal_title：Antiviral therapy
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更新日期：2007-01-01 00:00:00
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pub_type： 杂志文章,随机对照试验
doi：10.3851/IMP2358
更新日期：2013-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 临床试验,杂志文章
doi：
更新日期：1996-04-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 评论,杂志文章
doi：10.3851/IMP2561
更新日期：2013-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:Limited data suggest that glycated haemoglobin (haemoglobin A1c; A1C) values might not reflect glycaemic control accurately in HIV-infected individuals with diabetes. METHODS:We evaluated repeated measures of paired fasting glucose and A1C values in 315 HIV-infected and 109 HIV-uninfected diabetic participa...
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doi：10.3851/IMP1557
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doi：10.3851/IMP3147
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更新日期：2012-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
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更新日期：1996-08-01 00:00:00
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pub_type： 临床试验,杂志文章
doi：
更新日期：2007-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：10.3851/IMP2411
更新日期：2012-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章,多中心研究
doi：
更新日期：2005-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：10.3851/IMP2350
更新日期：2012-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
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更新日期：2009-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
